Lin Hedehus

The year of #2021 is ending and so is the era of the @HelinLab at #MSKCC. Thank you to all my colleagues for a great time here, and to @lydfinley for ensuring I can stay until I finish my PhD! I’m excited for the #postdoc opportunities that 2022 may bring!🤞

@bernstein_lab @SBDRCatMtSinai @MSHSDerm Amazing, congratulations Dan!

Congratulations to Dan Filipescu, instructor in the lab, for receiving this Transition to Independece minigrant!! 🍾 So grateful to be part of the @SBDRCatMtSinai and @MSHSDerm community!

@LaugesenAnne @wgarland10 Yes! I’ve optimised on the protocol from the lab and it works well for mESCs now. Shoot me message with your email then I’ll send it to you Will ☺️

@wgarland10 @LinHedehus - did you like the ones you used on mESCs? 😊

Science Twitter - can you point me in the direction of your favourite subcellular fractionation protocol? Bonus if it is optimised for mouse ES cells. Finding something that is consistent and clean has long been a challenge 😅

@Adrian_H @zeusPharma @MicrobiomDigest If you say so

@LinHedehus @zeusPharma @MicrobiomDigest and I am not being condescending; I am just pointing out that that the experiment you described as "not entirely impossible" was, in fact, 100% impossible, and it matters.

Question for my tweeps: it is expected that an uncropped Western blot shows 3 different proteins, each of which was immuno-precipitated with a different antibody? I am just confused about this uncropped blot (bottom right of this collage). pubpeer.com/publications/C…

@Adrian_H @zeusPharma @MicrobiomDigest I have never said I was defending the paper. I’m sorry you made that interpretation but that’s on you

@LinHedehus @zeusPharma @MicrobiomDigest Because you are defending it, and you haven’t read it or the critiques. People are getting a bit tired of the gaslighting and the defenses of 33 fraudulent papers, even if they are inadvertent.

@Adrian_H @zeusPharma @MicrobiomDigest Idk why you have come to the conclusion that I’m defending this paper - just offering some nuance here. But I’m not going to entertain the condescending tone of this thread any longer. I hope being a keyboard warrior made your day.

@LinHedehus @zeusPharma @MicrobiomDigest Can you tell me whether this part of the experiment is possible? #7" target="_blank" rel="nofollow noopener">pubpeer.com/publications/C…

@MicrobiomDigest In this case I would have marked the edges of the individual membranes directly on the film with a marker so there would be no confusion that it was run on three different gels… not that I have ever exposed blots from 3 separate experiment on one film. It’s just confusing

@MicrobiomDigest It’s just 3 IPs that have been run on 3 gels. Membranes have been cropped a bit before immunoblotting and then they have been exposed on the same X-ray film. Unusual to run 3 different IPs at the same time but.. could be okay if they explain it better

Happy International Women’s Day! A few of the ladies in our lab are currently focusing on studying the effects of mTORC1 on organismal growth 👩‍🔬🧫🤰#WomenInScience

I think it's pretty great that on the eve of #InternationalWomensDay, they published a paper providing the recipe to simply cut out men altogether 😂. (jokes aside, this paper is seriously cool) pnas.org/doi/full/10.10…

Congratulations to @paigearnold2, @__btjackson and the rest of the @lydfinley lab on publishing this amazing work in @Nature !!#noncanonical #TCAcycle

Preparing talks is more fun when Denmark is crushing the Netherlands in Men’s EHF EURO #handball 2022 🤾🏼‍♂️🤾🏼‍♂️🇩🇰

To me, a major problem is the viewpoint that there is/should be a one-way flow from academia -> industry. Academia should recruit industry scientists at all levels and vice versa. Half of our lab has sig industry experience and it has transformed the way we approach questions.

Meanwhile, former faculty member Pedro Domingos unfortunately used the holiday weekend to yet again tweet meritless, sexist, inflammatory, attention-seeking commentary that reflects poorly on him and everyone associated with him. We, once again, repudiate his views. 2/5

@TaylorJ_MD @HelinLab @lydfinley Thank you! I will have a look at it!

@LinHedehus @HelinLab @lydfinley Check out our Cancer Epigenetics T32 for postdoctoral training. umiamihealth.org/sylvester-comp… I’m happy to answer any questions!

The year of #2021 is ending and so is the era of the @HelinLab at #MSKCC. Thank you to all my colleagues for a great time here, and to @lydfinley for ensuring I can stay until I finish my PhD! I’m excited for the #postdoc opportunities that 2022 may bring!🤞

@mehdiDamaghi @HelinLab @lydfinley Thank you! I will have a look at it.

Had an amazing week at the @epicypher #EpiCypher2021 conference in #clearwaterFL! A lot of great talks, exciting research and new connections! I’m excited for the future of #epigenetics.. (photo: bunch of happy grad students)

Decoding the function of Bivalent Chromatin in development and cancer. Bivalency does NOT poise genes for rapid activation BUT protects promoters from de novo DNA methylation. Bivalent domains have a function after all! tinyurl.com/375t57zr