Lingyan Chen

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Lingyan Chen

Lingyan Chen

@LingyanC

Senior Research Scientist in statistical genetics @ Novo Nordisk Research Centre Oxford

Oxford, England Katılım Aralık 2014
227 Takip Edilen89 Takipçiler
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Marios Georgakis
Marios Georgakis@MariosGeorgakis·
GWAS sample sizes are officially in the 7-digit realm🧬 New GWAS for eGFR in 2.2 million (!) individuals @ScienceMagazine 👉1,026 genomic loci 👉8,901 putative causal variants in 1,818 credible sets in fine-mapping 👉convergence across 1,060 genes in multi-omic integration
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Marios Georgakis
Marios Georgakis@MariosGeorgakis·
So many cool papers while I was away❗️ 🧬GWAS of 11 autopsy-assessed neuropathology traits (N=7,786)🧠 👉Great resource for cognitive aging research (often dominated by less precise neuropsych phenotypes) 📰Paper: nature.com/articles/s4158… 📊Summ stats: dss.niagads.org/datasets/
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nature
nature@Nature·
Three scientists involved in developing the blockbuster anti-obesity drugs that are currently changing the health-care landscape are among the winners of this year’s prestigious Lasker Awards go.nature.com/4de67cw
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Marios Georgakis
Marios Georgakis@MariosGeorgakis·
A study @JAMA_current assessed hsTrop I, hsTrop T, nT-proBNP, proBNP, hsCRP as CV risk predictors across 28 cohorts (N=164K, f-up 12y): 👉all biomarkers associated with incident CV events 👉only slight improvements in c-index (changes of <1%) jamanetwork.com/journals/jama/…
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The Lancet
The Lancet@TheLancet·
Among 20 leading risk factors for years of life lost in 2040, reference forecasts point to 3 metabolic risks—high blood pressure, high BMI & high fasting plasma glucose—as top risk variables. Find out more in a @TheLancetEndo Review: hubs.li/Q02wZNKt0
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Marios Georgakis
Marios Georgakis@MariosGeorgakis·
The GWAS summary stats for circulating cytokine levels from our study are now available through GWAS catalogue: Accession numbers GCST90428399 to GCST90428438 ftp.ebi.ac.uk/pub/databases/…
Marios Georgakis@MariosGeorgakis

Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find 👉169 loci associated with cytokine levels 👉 promising drug targets for immune-mediated diseases Check out for more: medrxiv.org/content/10.110…

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Dr Cathryn Lewis
Dr Cathryn Lewis@cathrynlewis·
📢 Today we launch the @PGCGenomics Video Textbook! A structured training program in psychiatric genetics, analysis methods and software tools. Open access, do share widely. #WCPG2023 1/n
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Stephen Burgess
Stephen Burgess@stevesphd·
Proud to say our Mendelian randomization book is now available in Chinese: pmphmall.com/gdsdetail/6477…. This translation is the result of months of co-operation with a network of researchers and academics in China. We hope this enables a wider audience to benefit from its contents.
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Yu Xu
Yu Xu@IamYuXu·
Really Excited - our work was just out @Nature! Grateful for the invaluable contributions of our collaborators from around the globe and the leadership of @minouye271 , making all these possible. Looking forward to a lot more exciting studies ahead!
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Adam Butterworth
Adam Butterworth@aidanbutty·
Great to see our work from the CARDIoGRAMplusC4D Consortium on the genetics of coronary artery disease finally out in Nature Genetics nature.com/articles/s4158… A short 🧵 to highlight some key findings..... 1/8
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Lingyan Chen
Lingyan Chen@LingyanC·
Many thanks all for the nice questions. If you miss the talk or would like to have follow up discussions, please join us at the #ASHG2022 digital forum on 15 Nov. 😊
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Lingyan Chen
Lingyan Chen@LingyanC·
3. Do pQTLs go in the same directions as eQTL? a. Proteins in circulation are not reflective of what is going on at the tissue level b. Different regulatory mechanisms of RNA and proteins (transcription vs translation)
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Keşfet

@ScienceMagazine @CScottGallagher @NIH @AllofUsResearch @JAMA_current @TheLancetEndo @uk_biobank @Nature