Mangiante

Read this week's Cancer Discovery #ResearchWatch: aacrjournals.org/cdnews/news/20… High-risk ER+ #BreastCancers Genomically Resemble HER2+ Tumors, a summary of the study by Kathleen Houlahan, @LiseMangiante, Cristina Sotomayor-Vivas, @alvinahere, @cncurtis, and colleagues @StanfordCancer

@SandraOrtizCua @crcl Thank you @SandraOrtizCua and thanks to the @crcl Symposium organizers for the amazing opportunity!!

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

Again, thank you to the patients, their families, the patient advocates and all the amazing scientists involved!!

This approach moves us closer towards the goal of tailoring treatments for aggressive ER+ subgroups based on underlying vulnerabilities beyond what is possible within the traditional hormone receptor-centric framework.

The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! nature.com/articles/s4158…