MANGO LAB

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MANGO LAB

MANGO LAB

@MANGOLAB1

Genomics, adaptation, transposable elements, extrachromosomal DNA, horizontal transfer, crop, ecosystems

Perpignan, France Katılım Mayıs 2021
68 Takip Edilen141 Takipçiler
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Patrick Hsu
Patrick Hsu@pdhsu·
Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.
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Science Magazine@ScienceMagazine

A new Science study presents “Evo”—a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo’s ability to predict, generate, and engineer entire genomic sequences could change the way synthetic biology is done. Learn more in this week's issue: bit.ly/3OsmUPr

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Gregor Diensthuber
Gregor Diensthuber@GDiensthuber·
VERY excited to share SeqTagger with the world! If you want to learn more about our super-fast and accurate demultiplexing tool for direct RNA-sequencing (DRS), check out the thread below. bit.ly/3ClVYxG (1/15) 🧵
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Ian Henderson
Ian Henderson@hendersi·
Amazing!
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Maria Nattestad
Maria Nattestad@marianattestad·
Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using my tools Ribbon and SplitThreader: youtu.be/TP-H9epbsTM
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Astropierre
Astropierre@astropierre·
On dirait une forêt, mais il s'agit en réalité... d'un seul arbre de 47 000 troncs qui couvre une superficie de 42,6 hectares dans l'Utah 🇺🇸. Son âge est estimé entre 16 000 et 80 000 ans, faisant de lui le plus vieil organisme vivants sur Terre Source : nature.com/articles/d4158…
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L'important
L'important@Limportant_fr·
Il y a quelques années, les voix des élèves de l'école de musique afghane résonnaient à Kaboul. Aujourd'hui, le silence règne. Les talibans ont fermé l'école, interdit la musique et interdit aux femmes et aux filles de chanter @HabibKhanT
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Rebecca Eccles
Rebecca Eccles@RLEccles·
Congrats @CancerGrand team eDyNAmiC- 3 papers in @Nature and ecDNA on the cover🥳 But how did we get here?! Read more about how @mischellab @HowardYChang and @MariamJHanjani came to work on ecDNA, the incredible team and their findings cancergrandchallenges.org/news/team-edyn…
Cancer Grand Challenges@CancerGrand

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

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Matt Jones
Matt Jones@MattG_Jones·
Ecstatic to see our latest effort published in @Nature! It's been a privilege co-leading this project with @kinglhung, @ivywtl, and EJ. We combined single-cell genomics, imaging, and evolutionary modeling to find that cooperative ecDNA species are co-inherited in mitosis.
King L Hung@kinglhung

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…

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Chris Bailey
Chris Bailey@cbailey_58·
Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in @Nature
Charles Swanton@CharlesSwanton

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature nature.com/articles/s4158…

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King L Hung
King L Hung@kinglhung·
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…
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Charles Swanton
Charles Swanton@CharlesSwanton·
ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature nature.com/articles/s4158…
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Anton Henssen
Anton Henssen@anton_gh·
Three papers and the cover of @Nature on ecDNA !!! 🔥🔥 What an amazing achievement by our @CancerGrand team eDyNAmiC led by @mischellab @HowardYChang @CharlesSwanton @MariamJHanjani @cbailey_58 @kinglhung and many more !!! 👏🏻👏🏻👏🏻👏🏻🍾🍾🍾🍾 Much more to come soon.
Cancer Grand Challenges@CancerGrand

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

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Cancer Grand Challenges
Cancer Grand Challenges@CancerGrand·
Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00
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Lorenzo de la Rica (he/him)
Lorenzo de la Rica (he/him)@LdelaRica·
Also, let's take a moment to appreciate the beauty of this cover, which shows extrachromosomal DNA (ecDNA) next to chromosomes. ecDNAs are linked to therapy resistance and poorer outcomes for patients. Credit: E. MacKenzie and J. Claus (@phospho) nature.com/nature/volumes…
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Keşfet

@ScienceMagazine @HabibKhanT @Nature @CharlesSwanton @CancerGrand @mischellab @HowardYChang @kinglhung