Mahesh Gopakumar

What sets Brexpiprazole (Rexulti) apart as a third-generation antipsychotic? Brexpiprazole is a partial dopamine D2 agonist classified as a serotonin-dopamine activity modulator (SDAM). Its unique receptor profile offers a therapeutic edge by addressing: ✅ Positive symptoms (hallucinations, delusions). ✅ Negative symptoms (emotional withdrawal, lack of motivation). ✅ Cognitive deficits, an often-overlooked challenge in schizophrenia. But how does Brexpiprazole achieve these outcomes? Let’s break it down 👇

@911poet @CHARMER_Study Find it quite strange you’ve retweeted this platitude @CHARMER_Study Are you under the impression that as psychiatrists we aren’t constantly striving to deprescribe/ in the first place avoid unnecessary meds especially in older people?

"For many reasons now, going to a psychiatrist is probably the most dangerous thing you can do in the Western world." —Dr. Peter Breggin

@subodhdave1 @LondonMarathon @NHSBT @Derektracy1 @DrJonGoldin @OwenBowdenJones @lennycornwall @raj_psyc Hope you get better soon and racing. Running my first marathon in just over a week. Hope to be as fast as you someday!

Gutted not to run @LondonMarathon on Sat Post #tokyomarathon hamstring tear not ok yet But on a +ve note (Pun alert) could donate blood @NHSBT #RunningMedics #Running #LondonMarathon Wish all runners good luck @Derektracy1 @DrJonGoldin @OwenBowdenJones @lennycornwall @raj_psyc

@DrNeilCrossley Congratulations!

@deoman11099 @LSCFTMedEd @LSCFTMedics @rcpsych Superb !! 🏃🏻‍♂️

10km done :47 mins 21 sec. Slowing building endurance for full marathon in next 5 months. Still 2 hrs indoor bicycle ride left for today. Keep pushing forward. Stay active and healthy. Dr Deoman Gurung,ST6 dual psy trainee. @LSCFTMedEd @LSCFTMedics @rcpsych

@SusilPallikada1 Do you think we’re often too quick to deprescribe statins in older people?

Hypertension and Lipid clinics for the last four months - really rewarding rotation. Lots of lessons but two stick out: ACE-i and statins are amazing drugs (something you don’t get to appreciate to the same level doing IP work).

@1to2arun So jealous. Hope you had a good time!

@deoman11099 Congratulations Deoman! Hope you had a good time.

Mrcpsych graduation after almost 3yrs passing it. Celebrating with my 2 daughters phoenix and symphony

@ProfRobHoward I always think of Galantamine when I see snowdrops.

Snowdrops in Hyde Park. Seasons seriously messed up.

@DrSelvarajah 🤣🤣🤣🤣🤣

@dan26wales Thanks Dan this is really useful!

@subodhdave1 @OwenBowdenJones @DrJoanneFarrow @FemiMind @chrisol1 @lennycornwall @AlexBThomson @PsychSleepy @rcpsych @open_debate @sheona_macleod @lungsatwork @EllenWilkinson6 @Derektracy1 Wow that’s an amazing time! Well done!

#ChicagoMarathon done! 3:03 2nd fastest time ever #RunningMedics #Running #RunningPsychiatrists @OwenBowdenJones @DrJoanneFarrow @FemiMind @chrisol1 @lennycornwall @AlexBThomson @PsychSleepy @rcpsych @open_debate @sheona_macleod @lungsatwork @EllenWilkinson6 @Derektracy1

@EleanorMorton The Cappella Palatina in the Palazzo dei Normanni and stuccos by Serpotta in the Oratorio di San Lorenzo are a must see. And you can’t leave Sicily without having pistachio ice cream in a brioche bun.

Specifically Palermo

I'm afraid there's no video this week. My creative juices are still rehabilitating, so I'm going on holiday to Sicily for a week! Any recs for things to do in Sicily? 🌞 🍋 🌊

@sean9n @ProfRobHoward @dan26wales 💯 Persistent delirium is a huge issue and not enough support. Carers experience so much stress.

@ProfRobHoward @dan26wales Awful. We need a national delirium follow up service

Week 1. Delirium, AKI etc. Background of dementia. ZF around the house. Carers qds. Illnesses treated but mostly lying in bed. Not eating much. Not talking much. “Not engaging. Probable new baseline. D2A/24 hr care” 3/52 later. Eating, drinking, talking, colouring in. Walking 30m

@Paulineb1982 @RachelSTRGMMH @AnnJinOT @GMMH_NHS @nigelgmmhrehab @iamtrishdw Great to see everyone enjoying our Tovertafel already! 👍🏽👍🏽

@MGops @RachelSTRGMMH @AnnJinOT @GMMH_NHS @nigelgmmhrehab @iamtrishdw

🍁 Maple 🌈 Ward Toval has been put up today patients and staff have enjoyed this as an activity 👍 😀 #Dementia #activities

@Paulineb1982 @danxhardyx @iamtrishdw @GMMH_NHS @nigelgmmhrehab @AnnJinOT Great work Pauline! I’m sure everyone enjoyed it. 👍🏽👍🏽

🍁 Maple Ward 🌈 👩‍🎨 #Art #FridayFeeling #faceexpression @MGops @danxhardyx @iamtrishdw @GMMH_NHS @nigelgmmhrehab @AnnJinOT

@SampadaGadde @BhandaryNishan @GMMH_NHS Great to have you with us @SampadaGadde. Glad you enjoyed your time here. I’m sure you have a great career ahead of you.

@BhandaryNishan @MGops @GMMH_NHS @BhandaryNishan is to be commended for providing me with this extraordinary opportunity. My time at @GMMH_NHS was enlightening with supportive colleagues and an extremely helpful supervisor @MGops, who offered guidance at every turn. This was a great start to my NHS experience.

Thank you @SampadaGadde for this kind gesture. @MGops has done a sterling job as your supervisor. You have shown great enthusiasm in your #ClinicalAttachment & I hope you find a job soon, and come work with us @GMMH_NHS. All the very best & keep in touch for any career advice

@wendyburn My parents went last month! Loved it.

Anyone been to the Maldives? I’ve never done a holiday like that and feeling tempted now travel is possible again.

@deliriumkrish My first and probably last 2 Wordle 236 2/6* 🟩⬛🟨⬛🟩 🟩🟩🟩🟩🟩

Wordle 236 2/6 ⬜🟩⬜🟩🟩 🟩🟩🟩🟩🟩

@tadhg50 Congratulations! 🥳

Congratulations to my daughter @liadory1 on her graduation day today MA in Social Work (with Distinction I believe! @BridgewaterHall @ManMetUni