ModernHealthspan

Huge thanks to Dr. Vladimir Heiskanen for joining to dive into the science of Red Light Therapy 💡My key takeaways: There is more nuance than I thought but it does: - Boost cellular function by increasing ATP - Promote collagen synthesis & skin elasticity youtu.be/fegThHgi9jM

We spend too much time trapped in our thoughts. The One-Armed Bandit brings you back into your body. It brings you into the present moment. Mind and body working together as one. When you find that balance, the mental noise completely shuts off. Just pure body awareness. Once you feel it for yourself, you get it. Get the printable guide to mastering the One-Armed Bandit: ow.ly/bWfw50Zi8W2

@BradSchoenfeld So, if I want hypertrophy and strength gains, 3x1 at 90% 1RM followed by 45% until 2 RIR will give me both? I was concerned about sending conflicting signals to the muscle by finishing off the heavy set with lighter weights to failure.

A new study compared  a heavy-load (H) protocol with a combined heavy + light load (H+L) protocol on measures of strength and hypertrophy (PMID: 42323749). The heavy load group performed 3 sets of maximal isokinetic knee extension contractions on a dynamometer and 3 sets of 1 repetition at 90% 1-RM on the leg press. The H+L group performed the same heavy load protocol but also performed an additional 3 sets of leg presses for as many reps as possible at 45% of 1-RM until reaching 2 RIR. Results showed: .: --The two training protocols produced similar gains in isometric and dynamic strength. --The H+L protocol led to substantially greater increases in vastus lateralis muscle size (21% vs 4%) despite no additional strength gains. It's not clear whether the greater hypertrophy was due simply to a higher set volume or two distinct mechanistic drivers (e.g., differential anabolic pathways, fiber type specific stimulation, etc) or perhaps a combination of both. Take-home: Bigger muscles don't necessarily explain why people get stronger during the initial stages of resistance training. Combining heavy and light load training may help to optimize the combination of strength and muscle size.  pubmed.ncbi.nlm.nih.gov/42323749/

For more details, the fill interview is here: youtu.be/2WHWRy7WJXM

Huge thanks to Dr. Purnima Kumar (@UMich) for a wild interview on oral-systemic health! Did you know uncontrolled blood sugar pushes your healthy mouth microbiome into dysbiosis; switching from oxygen breathing to fermentation & triggering a vicious inflammatory loop.

@siimland Crazy! I hope you figure it out and get the account back.

Instagram just deleted my account Potentially because of a reel about how Messi's childhood growth hormone deficiency might make him live longer than an average person... Does anyone have a contact at Meta? Was probably AI, but my appeal got rejected as well - so perma deletion now.

I just wish I had understood this earlier in life! If it is something you need or want to do but are afraid. Do it, and keep doing it, until the fear goes away.

“Wasting your time doubting whether you’re going to be successful is pointless.” — Kobe Bryant

Thanks to Dr. JoAnn Manson for a great talk about a landmark VITAL trial discovery: 2,000 IU of Vit D daily slowed telomere loss by 3 years compared to placebo over a 4-year period. We also discussed the 39% reduction in autoimmune risk. youtu.be/XvtI-Ts0tWA

What you do in private always shows in public, and this is such good news. Your diet shows in your energy. Your diet shows in your skin. Your diet shows in your confidence. Your diet shows in your results. The whole foods you eat when no one’s watching…the vegetables, the healthy fats, the clean proteins, they don’t just disappear. They become the clarity you feel at 2pm instead of brain fog. They become the natural glow people notice. They become steady energy that lasts all day, not the crash-and-burn cycle of processed foods and sugar. You can’t fake real nourishment. Your body tells the truth. Feed it real food, and it shows. Skip the nutrients it needs, and that shows too. You are what you cultivate when no one is watching. And every single meal is either building you up or breaking you down. Choose foods that serve you.

GLP-1s are more than a just weight loss. Dr. Mikhail Kolonin’s 2025/2026 data shows these molecules induce adipocyte browning and activate telomerase (TERT) in adipose tissue, even without weight loss. We're shifting from appetite control to active metabolic re-programming.

You don't magically become healthy. You practice it. You notice you're making a bad choice and correct it, over and over again until the good one becomes automatic. The people who figured this out aren't special. They just decided to take it seriously one day and never stopped.

Big thank you to @nirbarzilai for joining us and ranking 4 FDA-approved drugs as potential longevity medicines and you've probably heard of them. Metformin, GLP-1 agonists, SGLT2 inhibitors and bisphosphonates. youtu.be/YJIAekRlPjk

Kobe Bryant once said: “I have nothing in common with lazy people who blame others for their lack of success. Great things come from hard work and perseverance. No excuses.”

Most electrolyte products are missing something fundamental. You can take all the potassium you want — but without enough magnesium, it won't stay where it needs to be. Magnesium activates ATP, and ATP powers the pump that actually moves minerals into your cells. Skip magnesium, and the whole system stalls. This is basic physiology that most products ignore. If you've ever wondered why you're still exhausted, still cramping, still thirsty no matter what you take — this video is going to change how you think about hydration completely.

Mitochondrial Transplant Reverses Disease Scientists just transplanted healthy mitochondria into diseased cells -- and reversed Parkinson's, Leigh syndrome, and mtDNA depletion. In Cell. As a medical school professor, I can tell you this is one of the most important papers of 2026. Chinese researchers solved the delivery problem that's challenged mitochondrial medicine for decades. The breakthrough: wrapping healthy mitochondria in red blood cell membranes. Delivery efficiency jumped from under 5% to 80%. The results: - Rescued mitochondrial defects in patient-derived cells - Reversed mtDNA depletion syndrome in mice - Extended survival in Leigh syndrome mice - Prevented neuron loss and restored motor function in a Parkinson's model Tested in both mice and monkeys. This is what I wrote about in "Lies I Taught in Medical School" -- we treated mitochondrial diseases as untreatable because we couldn't fix the powerhouse. Now we can replace it entirely. "Organelle therapy" is no longer theoretical. It's here. Full breakdown coming on the Health Longevity Secrets podcast. Source: cell.com/cell/abstract/… #Mitochondria #Parkinsons #RegenerativeMedicine #CellTherapy #Longevity

Thanks to @ProfValterLongo for a fascinating conversation on his new book Fasting Cancer. Key insight: While on an FMD healthy cells enter a protected mode while cancer cells can't, making them more vulnerable to therapy. Full interview:

Grateful to Dr. Luigi Ferrucci from @theNIAgov for sharing his insights from 60 years of Baltimore Longitudinal Study. We talked about how they measure the pace of aging, how it relates to healthspan and how mitochondria could be the source of all aging. youtu.be/NS-VxoHltdw

At NIH, we’re accelerating the future of medical research, advancing innovation and repurposing existing drugs to deliver new treatments faster for the American people🔬🇺🇸

I don't know where Dr Eades would put me on the continuum of properly understanding a paper but I agree with his point!