Maureen Hillenmeyer

Great slide (Bluestar Advisors) about progress across different cancers. They looked at OS improvement in 1st line patients and divided indications to blue ocean or red ocean based on magnitude of improvement. Biggest progress was in melanoma and renal cancer (PD1/CTLA4), HRD-ovarian cancer (PARP) and breast cancer (CDK4, HER2). Good news is a lot of the blue ocean indications at the bottom will see new effective therapies that should translate to a meaningful benefit when they reach 1st line: 💢Head and neck - EGFR bispecifics (peto, amivantamab) 💢Small cell lung cancer - DLL3 T cell engagers and Topo1 ADCS (DLL3, SEZ6, B7H3) 💢Ovarian/ endometrial - Topo1 ADCs (FRa, CDH6, NaPi2b) 💢Pancreatic - RAS inhibitors GBM, colorectal and liver still look very challenging...

“Doctor, what is the right therapy for me?”. Lately, the answer to this Qx has become increasingly unclear among pts with ER+ MBC. We have CDKs, SERDs, PI3K-Akt-mTOR agents, ADCs, chemo— & insufficient biomarkers. Thanks @OncNewsCentral for the interview. oncologynewscentral.com/breast-cancer/…

A standing ovation moment at #ESMO25 In front of more than 9,000 cancer specialists and researchers, the Phase 3 RC48-C016 trial redefined the outlook for HER2-expressing urothelial cancer: Disitamab vedotin + Toripalimab nearly doubled overall survival over chemotherapy — marking the arrival of the ADC + IO era in this disease. #UrothelialCancer #Oncology #DisitamabVedotin #Toripalimab #Immunotherapy #ADC #IOcombination @myESMO @OncLive @CParkMD @tugbawitter @Dr_ElvinaA @atakansare2016 @drmukremin @dr_yakupergun @OncoAlert @alimurattat @DrYukselUrun

in 2L HER2+ metastatic breast cancer, in 10 years, from 2012 to 2022, we have reduced risk of progression and death by !!80%!! - Lapatinib + cape 6.4 months - TDM1 9.6 months - TDXd 29.1 months #ESMO25 Dr. Rupert Bartsch

🚨 Cancer of unknown primary (CUP) has long been a therapeutic challenge with poor outcomes. New data show that molecularly guided therapy and immunotherapy can improve survival, while ctDNA, methylation profiling, and AI-based pathology enable precision strategies. 📖 @NatRevClinOncol DOI 👉 doi.org/10.1038/s41571… #CánCare #oncology #CUP #precisiononcology

T-DXd is approved for the treatment of patients with ANY treatment-refractory HER2+ (IHC 3+) tumor, making of it the first agnostic ADC. Unlikely to be the last. Key priority: ensuring that HER2 testing is expanded across cancer types. Exciting times! fda.gov/drugs/resource…

After a standing ovation at #ESMO23, the EV-302 phase 3 trial of EV/pembro (vs platinum/gem) in 1L mUC by @tompowles1 et al is published on @NEJM. OS nearly doubled with the ADC/IO combo. Targeted chemo delivery keeps reshaping practice across tumor types. nejm.org/doi/full/10.10…

$PFE $MRK $SGEN Padcev + Keytruda in 1L urothelial EV-302, via Thomas Powles. Survival benefit irrespective of cisplatin eligibility or PD-L1 status. New SoC #ESMO23 $BCYC

🟢DESTINY-Breast04: standing ovation more than deserved👏. T-Dxd showed to improve PFS and OS in pretreated HER2-low (1+ and 2+ ISH -) #MBC patients vs TPC. "The ADC era has just begun also in HER2-low BC". These results speak for themselves. @CamillaLisanti #ASCO22 #BCAreporter

$AZN $MRK Lynparza in 1L Maintenance BRCAm ovarian cancer data out in NEJM --> $CLVS $TSRO nejm.org/doi/full/10.10… PFS HR=0.30 One of the most amazing PFS curve this year!

The future of clinical trials is site-less, hopes @Science_37, @Novartis, and many others, writes @ElieDolgin in @NatRevDrugDisc rdcu.be/MK4d

Very cool figure of 87 new and emerging molecular targets at #AACR18 biocentury.com/bc-innovations… via @BioCentury

Who designs better synthetic routes -- humans or computers? #Chemists test out computer-programmed #syntheses for the first time: ow.ly/7DnT30iIwM0

Prediction of protein structure directly from DNA sequence is a holy grail of biology. Exciting new work from @MoAlQuraishi: biorxiv.org/content/early/… Different from other approaches (e.g., coevolution, simulations). Could maybe be combined with them for even greater accuracy.

Beautiful visualization of daily temperature changes. The earth looks like a beating heart. twitter.com/severeweatherE…

One-shot immitation learning from noisy labeled data!

So many pretty molecules (nearly 2/3 small molecules) approved in 2017. See 'em all here: cen.acs.org/articles/96/we…

More great stuff from @AsherMullard on genomics and drug development... Always worth reading/following. twitter.com/AsherMullard/s…

The many colors of a wasp’s microbiome. Just imagine what yours might look like... #microbiome #sciart #scicomm #wasps #microbialrainbow

You send plasma from same patient for cell-free DNA testing to two different companies. In nearly all cases, you get different results from each. Data offer humbling reminder of imprecision of #PrecisionMedicine. ja.ma/2BfT8G4