Marco Sciacovelli

📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Happy Sunday! Here are the most recent issues of bims-metlip, chock-full of new analytical and computational methods for #metabolomics and #lipidomics biomed.news/bims-metlip/20… biomed.news/bims-metlip/20… Brought to you in collaboration with @Bims_BiomedNews

#NatMetabPicks | In @Nature led by RK Jain, @geochurch & @mvh_lab (@Harvard) This work highlights the complexity of metabolic dependencies in metastatic site selection. nature.com/articles/s4158…

An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/6010Aqwbi Douglas Hanahan @CellCellPress

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Spatiotemporal regulation of energetic charge dictates T cell function @NatureComms

For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Albumin orchestrates a natural host defence mechanism against mucormycosis

🆕Paper in @NatureGenet from Georgios Kanellos in @owen_sansom's lab: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation nature.com/articles/s4158…

Now online: The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer doi.org/10.1158/2159-8…

Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria dlvr.it/TPlKxf

RESEARCH | F Kaluba, EC Lien et al. (@VAInstitute): Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. nature.com/articles/s4225…

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… A huge collection inside! Interesting finding: Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20… Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Great work from Suzan Ber and Alessandro Esposito regarding the metabolic reprogramming driven by different KRAS mutation in colorectal cancer. Thank you for involving me in this cool project! embopress.org/doi/full/10.10…

Last week's #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

Reawakening cAMP signalling in cancer cachexia go.nature.com/47UQfLF

Another PDOC position in my group to join an ongoing collaborative project between Sanger and BRIC. Funded by Open Targets. my.corehr.com/pls/uoxrecruit…

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity nature.com/articles/s4159…

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle dlvr.it/TNx50C