Dylan Ryan

Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors. New insights since the preprint (summarised below): 1) Biphasic IFN-I expression 2) Late phase IFN-I is mediated by mitochondrial nucleic acid signalling incl. cGAS-STING pathway 3) Reduced IL-1 and COX2 is mediated in part by autocrine IFN-I 4) Systemic IFN-I signalling in different tissues, notably the kidney, in vivo Please check it out! nature.com/articles/s4146…

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

Loss of the autoimmune risk gene TREX1 predisposes mice to autoimmunity and also promotes antitumor immunity, suggesting that targeting autoimmune risk genes may help with future cancer treatment. scim.ag/3P5oPwX

STING gain-of-function has primarily been described to cause pediatric-onset disease. Here, Riley, Kotzin, @FinckAmanda, @miner_lab et al. report a surprisingly high prevalence of adult-onset #SAVI among patients with common #autoimmune disease diagnoses. hubs.la/Q04g4NGQ0

Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia dlvr.it/TSTvJf

@NIH Also see our paper that characterized the direct effects of fructose on microglia via Glut5. nature.com/articles/s4158…

Researchers supported by NIH found that blocking brain immune cells from using the sugar fructose for fuel led to improved survival among most mice with brain cancer. While more research is needed to see if this type of approach could work for people, it may be a way to boost the immune system’s response to brain cancer in the future. Learn how these findings might shape future approaches: bit.ly/4dnJh5E

@FrezzaLab And he's back! Woohoo!

Good Sunday, mitolovers. There is a truly exceptional curated issue of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/20… Biomed News. Don't miss it #keepreading "You have to do nothing to be who you are. Nothing at all."-H. W. L. Poonja

Very happy to see our latest work out in @emboreports . Here we discover an unexpected role for IRF3 in STING-induced pro-inflammatory cytokine production: #article-info" target="_blank" rel="nofollow noopener">link.springer.com/article/10.103… Enjoy!

Super interesting! We have observed changes in (hyper)vascularization many times during aging but never really followed it up. So cool to see these findings + amazing imaging: Reversible hypervascularization drives cognitive decline and blood-brain barrier damage during aging. Great work by @erturklab. Congrats! biorxiv.org/content/10.648…

Two for Thursday: We want to highlight another fantastic collaboration, this time with William Oldham's lab at Brown University and our @N8Krah, demonstrating that MCT4 is a druggable target in pulmonary fibrosis. Check it out here: science.org/doi/10.1126/sc… @UofUHematology @huntsmancancer Congrats to everyone involved!

RFK is no better at psychiatric medications than he is about vaccines. RFK's "overmedicalization crisis" thread is a master class in using true-ish numbers to imply a false conclusion. Let's go through it. 🧵 /1

The mechanism by which macrophage cells sense danger to drive an immune response and inflammation has been elusive. A new report highlights change in cell volume as the signal @JCellBiol rupress.org/jcb/article/22…

Very excited to report on our lab’s unexpected adventure into subtyping cancer cachexia by way of anatomy, where we study the evolution of the bodies (not the genomes!) of patients with cancer during profound weight loss. Led by Sonia Boscenco. medrxiv.org/content/10.648…

🚨 Proud to share our new study in @CellPressNews: B cells producing auto-Abs that neutralize type I IFNs in severe viral infections. Work from AI2B_lab @NeckerInem, @casanova_lab, @GorochovG and Rey’s labs @institutpasteur. doi.org/10.1016/j.cell…

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.

The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice dlvr.it/TSPbQG

@WestLabMito @ImmunoFever @wellcometrust Thanks Phillip!

@RyanLab_TCD @ImmunoFever @wellcometrust Congrats Dylan!

I’m delighted to share this news and very grateful to the @wellcometrust for supporting our work. This award will allow us to build a new research team at Trinity College Dublin investigating how inherited mitochondrial DNA mutations influence immune responses and infection susceptibility in mitochondrial disease. We hope this work will provide new mechanistic insight into mitochondrial disease, while also informing broader questions around mitochondrial dysfunction in infection, inflammation, ageing, and sepsis. I’m particularly excited that we will soon be recruiting for both a Research Associate and Research Assistant position in the Trinity Biomedical Sciences Institute. These roles would suit people interested in mitochondrial biology, immunology, infection, metabolism, and translational disease mechanisms. More details will follow shortly, but please feel free to get in touch if interested! #mitochondria #immunometabolism tcd.ie/news_events/ar…

@gavinmcstay2 @wellcometrust Thank you Gavin!

@RyanLab_TCD @wellcometrust excellent news @RyanLab_TCD and congratulations!