Mark Shlomchik

@pitt_immunology @ShlomchikLab @jclinicalinvest Also check out the commentary by Dr Vinuesa @carovinuesa in the @jclinicalinvest . Kudos especially to Dr Claire Leibler @ClaireLeiber who led the study.

@ShlomchikLab and his team have solved a 20-year #lupus mystery! In a new @jclinicalinvest paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR

Check out the N&V in @NatImmunol by Inaki Sanz about @elsner_rebecca @ShlomchikLab's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg. nature.com/articles/s4159…

@luoweicool @CellReports Great work, Wei and team. Very proud of you all for producing this insightful science.

I'm thrilled that the very first paper from my lab, also my first senior author paper, is now online @CellReports. cell.com/cell-reports/f…

@ZunigaLab Thank you Elina. I do think this is the right way, based on my experience. This is what mentoring really means.

Thank you @MShlomchik for such a wonderful and precious advise to the #globalimmuno community and beyond 👇 Mentors should figure out and adapt to the needs of each individual trainee...

@Ines_Marin_G @globalimmuno We are using MRL/lpr lupus model. It's a genetically triggered model. Similar findings regarding TLRs in other models, as I reviewed in the intro. The subject of the work and the talk is to figure out what's different between the TLRs. I showed that TIR domains are part of it.

@globalimmuno @MShlomchik 2- which model are you using? what is triggering lupus in it? Is it known WHY one of the TLRs is protective and the other pathologic? Only the intracellular signaling? Different recognition of different nucleotides (from… self? Infections?) may have a role? THANSKS!!!

Please ask questions for today's Global Immunotalk by Dr. Mark Shlomchik HERE by replying to this tweet. Don't forget to mention #globalimmuno. Mark will use the account @MShlomchik to answer questions.

@Ines_Marin_G @globalimmuno I think that B cells driven by TLR7-dependent autoAg (e.g. RNA, like you suggest) are presenting Ag and activating autoreactive pathogenic T cells and secreting inflammatory cytokines

@globalimmuno @MShlomchik Fantastic talk Mark, thanks! 1- what is producing glomerulopathy in the absence of ANAs (TLR9-)? The anti-RNA? Why the anti-DNA only don’t do the same in TLR7-?

@Ines_Marin_G @globalimmuno Turns out you don't need autoantibodies at all for glomerulopathy. Chan, et al. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189:1639-1648.

Check out the clip below to learn from the career advice given by last Wednesdays #globalimmuno speaker speaker Dr. Mark Shlomchik Full talk is available in “Global Immunotalks” YouTube Channel youtu.be/zm7RVMOLk_E

@Dr_Shuli @globalimmuno That said, there are strong B cell-intrinsic ects and our other studies only uncovered a regulatory role in B cells

@Dr_Shuli @globalimmuno For sure these mutants are functioning in other cells and we have not deconvoluted that, but it should be studied, perhaps collaboratively with others that specialize in those cells.

@Dr_Shuli @globalimmuno Sure, thanks for listening. It's been a fun project

ASCI member @mshlomchik @shlomchiklab @PittTweet in @JCI_insight: Severe lupus in TLR9- deficient mice requires B cell-specific TLR7: buff.ly/3YX65jS #Immunology

@ShlomchikLab @MShlomchik Happy 30th anniversary! Thanks for hosting a phenomenal symposium. No better way to celebrate!

@MadCapSci @luoweicool @luoweicool what's in that mug?

How junior faculty members stay on their toes… @luoweicool

Is IL-21R signaling in GC B cells different from naive B cells? How do different combinations of BCR, IL-21R and CD40 signals impact GC B cell fate choice? Differences between IgG and IgM GC B cells? For answers, check out our paper in Science Immunology: science.org/doi/10.1126/sc…

Good things come in pairs! ✌️ Check out these two new @SciImmunology articles investigating differentiation and signaling of germinal center #Bcells. 1️⃣ bit.ly/3xxbwsX by @luoweicool, @ShlomchikLab & co. 2️⃣ bit.ly/3xyQzh6 by @YUmmunology & co.

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice, say Kevin Nickerson @KMNickerson, Mark Shlomchik @mshlomchik @Shlomchiklab @PittTweet & colleagues. bit.ly/3ZgTxTw See video summary by Nickerson: youtu.be/YbRb282V6ZI #Autoimmunity