Mara Sherman Lab

With ✨ trainees Frank, Anny & Zainab ⁦@MSKCancerCenter⁩ we share a current understanding of the pancreatic #TME ⁦@NatureRevCancer⁩. It was inspiring to reflect on progress by so many in the field over the last decade. Hope we did yall justice. nature.com/articles/s4156…

Metastasis kills most cancer patients and grows from invisible seeds. How do these seeds escape from attack by immune cells? These seeds harness stress hormones!🤯 ⁦thanks to ⁦@nyscf⁩ ⁦@parkerici⁩ for their support. Today at ⁦@Nature⁩ nature.com/articles/s4158…

@KarunaMDPhD @CancerGrand @CR_UK @theNCI @BowelbabeF Congratulations!!! Can’t wait to see the great science to come!

Excited to be awarded a Cancer Grand Challenge grant as part of team REWIRE-CAN to develop new approaches to combat cancer #plasticity. Our goal: to see all #colorectalcancer patients become colorectal cancer survivors. Thank you @cancergrand @CR_UK @theNCI @BowelbabeF Yosemite!

Beautiful work x 2 and a banner week for the Finley lab - congrats to all authors! 🥳🎈

BIG congrats to @ArianaSattler @EceEksi1 @TeresaZimmers et al @OHSUKnight for this beautiful study of fibroblast-nerve Xtalk in pancreatic cancer. Complements the themes emerging from lovely recent work by @jeremynigri & team - many cool follow-up q’s! 🥳 insight.jci.org/articles/view/…

Delighted to announce the 11th edition of our ImmunoSchool, focused on inflammation and aging and how modulation of inflammation can promote healthy longevity. Open to trainees and faculty. FREE & online, March 23–25. immunoschool.org Register: eventbrite.com/e/internationa…

@Aiims1742 @dkfchang @UofGCancerSci This is beautiful!

New preprint from @dkfchang @UofGCancerSci: Morpho-spatial profiling of cancer-associated fibroblasts reveals architectural subtypes of #PancreaticCancer biorxiv.org/content/10.648… Morphology 🤝 Biology

Exceptional week in Israel attending an exciting conference on the tumor microenvironment organized by @ErezNeta and Ruthie at @WeizmannScience - exciting science and great to spend some time with the organizers and other speakers, including @MaraShermanLab and David Lyden

@lauradelongwood CONGRATS MY QUEEN 🥳🥳🥳

No longer assisting or associating...happy to share that I've been promoted to Professor!

I was already happy to have my student Haochen Zhangs’ work published in the February issue of @NatureGenet but my original painting made the cover as well! My second cover in 12 months! @CpcrMsk @MSKCancerCenter

BYO mustache and *apply*!!

🎉 New #BioRxiv pre-print 🎉 Do you want to know about #ageing? 👨👴 We know A LOT about it...because this work #aged us so much!! 🤣 biorxiv.org/content/10.648… No wait! 🤣 Try 2 below!

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. nature.com/articles/s4158… Beautiful work led by exceptional @HHMI Gilliam fellow @YoselinAPI and @MSK postdoc Tyler Park 🧵 1/

A second manuscript in CMGH 🎉🥳 and a wonderful collaboration with Farzad Esni where we combined our computational analysis of injured acinar cells and metaplasia with his extensive, elegant in vivo lineage tracing models to show that STMN1+ acinar cells are primed for proliferation and do not undergo metaplasia in response to injury or oncogenic KRAS mutation. What this means: - A surprising proliferative capacity in 'post-mitotic' acinar cells with important implications for tissue regeneration - A possible acinar 'cell type' or 'polarized state' - A distinct role for metaplasia separate from acinar replacement - our data suggests that metaplastic populations (like tuft cells!) mitigate inflammation - Acinar to ductal metaplasia and regeneration are concurrent mechanisms These data highlight that we have so much more to learn about how the pancreas mitigates injury, heals, and regenerates, but, with the tools at hand, it is possible to understand the pancreas with the ultimate goal of translating this knowledge to better treat patients with pancreatitis. cmghjournal.org/article/S2352-…

⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s4158…

@Aiims1742 @Perlmutter_CC @nyulangone @JohnPLeonardMD @nyugrossman @NYULangoneLI @NYULangoneBK @DrOscarLahoud @EmelineAvikiMD Amazing news!! Congratulations Anirban, congratulations NYU!! 🥳

I am honored to serve as the new Director of the @Perlmutter_CC. Thanks to Dean/CEO Alec Kimmelman @nyulangone for this opportunity. Excited to partner with @JohnPLeonardMD & the entire PCC community as we build our next exciting chapter. Lots to come! prnewswire.com/news-releases/…

Congratulations @theLundLab @Perlmutter_CC for her elegant paper @Cancer_Cell connecting the dots on IFN signaling, metabolism & lymphatic metastasis: IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma cell.com/cancer-cell/ab…

Paper out! In this study we show a malignant cell state with features of an epithelial injury-associated regenerative state drives conversion of premalignant lesions to malignancy and progression & drug resistance in advanced cancers. rdcu.be/eZ7g5

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Thrilled to share our deconstruction of a p53 therapeutic response in #LUAD- a step toward drugging #undruggable #p53! Thanks to our amazing team! @wmx162005 @alyssamkaiser @kbieging @LabElsaFlores @MikeOzawa @MLadanyi @arati_rajeevan @rajnitin @simone_alma