Margulies Lab

Welcome to the Margulies Lab twitter! We’re excited to be here and share all things heart related 🫀

In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise Simpub #ACC25 #JACCHF 🙏 #PZamani @MarguliesLab &team @PennCardiology @DukeHeartCenter

From monocytes pulling matrix by @KoladeAdebowal1 to cardiac in vitro models by Benjamin Lee from @MarguliesLab we continue the mechanobiofun at #cmbes2025 @ucsdbe @PennMedicine @PennCVI @UCSDJacobs

Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i Simpub #AHA24 & @JACCJournals #JACCBTS jacc.org/doi/10.1016/j.… 🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team @DukeHeartCenter @DukeMPI

CVI's Highlighted #PapersoftheWeek @BaurLab @DanKellyPennCVI rdcu.be/dUAoU

Congratulations @mikeibrahimmd !!

Congratulations to @AlexiaVite93 on placing in the Lightening Talk competition at @ISHR_NAS meeting in Long Beach, CA

CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/39018366/

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser scim.ag/7Nf

Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab 1/5 tinyurl.com/ynn6r2mz

A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF) spr.ly/6013i9WMc

Congratulations Alexia Vite! Awarded the American Heart Association’s Career Development Award and the Second Century Early Faculty Independence Award

CVI’s Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/38349539/

Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!

Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible! sciencedirect.com/science/articl…

New research examines the functional impact of alternative metabolic substrates in failing human cardiomyocytes ft. @AlexiaVite93, Timothy Matsuura, @kbedi88, Emily Flam, @AranyLab, @DanKellyPennCVI & @MarguliesLab (@PennCVI/ @PennCardiology) tinyurl.com/msp5hsma

Mechanical memory of human iPS-derived fibroblasts and cardiomyocytes. link.springer.com/article/10.100…

In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol @AlexiaVite93 link.springer.com/article/10.100…

Congratulations Benjamin Lee! Received the American Society for Clinical Investigation's Emerging-Generation Award

Using #cardiomyocytes from failing hearts, @MarguliesLab found that these cells exhibit metabolic inflexibility, relying on non-carbohydrate sources for contractility. Read the new #JACCBTS study by @AlexiaVite93, et al here: bit.ly/3OhibjQ