Maria Wahle

AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial @metaboflo #Alpha1Awareness bit.ly/4hzl64o

If you are at #ASMS2024 in Anaheim, do catch up with our lab-mates to know more about some of our exciting research in @labs_mann

Missed the Thermo User meeting at on Sunday on the new targeted MS? Our preprint on the Stellar MS shows how to use it in combination with the Orbitrap Astral and Evosep One to design 15N labeled protein based assays. Check out Maria Wahle’s poster ThP733 biorxiv.org/content/10.110…

A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N ... biorxiv.org/cgi/content/sh… #biorxiv_biochem

1/7 @labs_mann and Georg Wallmann @GeorgWa are proud to announce alphaDIA, our open source, next generation DIA search engine. Check out the preprint @biorxivpreprint biorxiv.org/content/10.110…

Deep visual proteomics translates to direct therapeutic advances for fatal drug-induced skin reactions. We pinpoint the JAK-STAT pathway as the key driver and demonstrate the potential of JAK-inhibitors in preclinical models and actual patient treatment. tinyurl.com/upbcx833

I'll be presenting IMBAS-MS our recently developed modular platform for efficient immunopeptidomics analysis in a webinar organised bei @ReSyn_Bio today! 🚀👩‍💻 Check out the details and register last minute here:

Join @MPI_Biochem @MariaWahle at @ReSyn_Bio EMERGE webinar to explore #immunopeptidomics with #Evosep One. Learn how the Whisper 40 method enables quantification of 5,000 HLA class I #peptides from #plasma through an automated workflow. Register here: us06web.zoom.us/webinar/regist…

🚨 EMERGE Webinar alert!🚨 Please join @MariaWahle from @labs_mann to understand the potential of plasma derived HLA peptides as described in their new pre-print biorxiv.org/content/10.110…! #MagReSyn #Streptavidin Registration: us06web.zoom.us/webinar/regist…

I am very excited to share the manuscript about our highly efficient immunopeptidomics workflow IMBAS. Combined with AlphaPeptDeep @jalew188 we acquire deep immunopeptidomes even from limited sample amounts. If you have any questions, feel free to reach out!

Read our multiplex-DIA story in @MolSystBiol! Automated & complete dimethyl labeling up to 5-plex with LysN. Reference channel doubles proteomic depth in single cells & RefQuant ensures precise quantification. #Proteomics #Quantification #multiplexDIA pubmed.ncbi.nlm.nih.gov/37602975/

MS-based proteomics and pathology create a synergy that provides new insights into complex disease mechanisms. You can read about our collaborative effort from @labs_mann and @ukaugsburg to uncover organ-specific effects in fatal COVID-19 beyond inflammation in @EmboMolMed

1/n The directLFQ paper is out now @molcellprot . So why a new algorithm for label-free quantification (LFQ)? doi.org/10.1016/j.mcpr…

Do you want to learn more about multiplex-DIA combined with the reference channel and how it can enhance single-cell proteomics and precision oncology? Then visit my talk at #ASMS2023 today in session ThOD at 8:50am. Looking forward to your questions and discussions.

Missed the Thermo breakfast meeting on Monday or have more questions about how the new #OrbitrapAstral MS can significantly increase performance and throughput for multiplexed DIA? I'm looking forward to discuss our results at my poster WP123 today at #ASMS2023 @labs_mann

I'm very excited to present the updates on our scan mode SynchroPASEF on the #bruker timsTOF at #ASMS2023. If you want to discuss how the high specificity and efficency of SynchroPASEF improves high troughput or single cell workflows, then visit my poster WP 122 today. @labs_mann

I am very excited to be at #ASMS23 presenting my work on immunopeptidomics! If you want to learn more about how to get >5,000 of immunopeptides from a few microliters of plasma and its longitudinal stability then visit my poster today at MP 651.

A new episode for our Deep Visual Proteomics: scDVP! We are proud to release a single-cell spatial proteomics map of mouse liver. 400 hepatocytes, 1700 proteins per cell, zonation of more than half of the proteome. Made possible by mDIA. @metaboflo bit.ly/scDVP

Excited to announce our multiplexed DIA workflow! Extremely robust and economical dimethyl labeling up to 5-plex with LysN. We introduce a reference channel that doubles proteome depth in single cells and RefQuant for robust ratio estimation as well. doi.org/10.1101/2022.1…