Lisa Schweizer

86 posts

Lisa Schweizer

Lisa Schweizer

@LisaCSchweizer

Katılım Haziran 2020
150 Takip Edilen160 Takipçiler
Lisa Schweizer
Lisa Schweizer@LisaCSchweizer·
Exciting new #DVP study on the origins of high-grade serous ovarian cancer (#HGSC). Extracting as few as 12 mutated cells from precursor lesions and profiling consecutive tumorigenesis, this study took a formidable technical challenge and identified novel therapeutic targets.
Matthias Mann Lab@labs_mann

Spatial proteomics & transcriptomics chart #ovariancancer evolution from fallopian tube precursors. Deep Visual Proteomics reveals early SUMOylation, TRIP13 epithelial driver, BGN therapeutic target & epithelial-stromal cooperation in progression. medrxiv.org/content/10.110…

English
0
0
6
2.7K
Lisa Schweizer retweetledi
Matthias Mann Lab
Matthias Mann Lab@labs_mann·
New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @MPI_biochem, our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology. biorxiv.org/content/10.110…
English
0
5
34
2.5K
Lisa Schweizer
Lisa Schweizer@LisaCSchweizer·
Check out the current issue of @Cancer_Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover. A team effort between @OvCa_UChicago @uchicago_obgyn and @labs_mann @MPI_Biochem.
Lengyel Lab@OvCa_UChicago

We’re proud to share that our lab’s recent publication by @LisaCSchweizer & @ErnstLengyel was selected for the cover of @Cancer_Cell! The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs. Read it here: cell.com/cancer-cell/fu…

English
3
0
14
1.4K
Lisa Schweizer retweetledi
Cancer Cell
Cancer Cell@Cancer_Cell·
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TMSCHQ
Cancer Cell tweet media
English
1
37
128
7.6K
Lisa Schweizer
Lisa Schweizer@LisaCSchweizer·
Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.
Ernst Lengyel@ErnstLengyel

Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicago nature.com/articles/s4158…

English
0
2
13
698
Lisa Schweizer retweetledi
Anirban Maitra
Anirban Maitra@Aiims1742·
Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!
Anirban Maitra tweet media
English
9
44
183
13.8K
Lisa Schweizer retweetledi
Sean Pitroda, M.D.
Sean Pitroda, M.D.@SeanPitroda·
📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…
Sean Pitroda, M.D. tweet media
English
9
46
155
20K
Lisa Schweizer retweetledi
Cancer Cell
Cancer Cell@Cancer_Cell·
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TLbW6y
Cancer Cell tweet media
English
0
43
136
10.5K
Thierry Nordmann
Thierry Nordmann@NordmannThierry·
A must-read, landmark paper by @LisaCSchweizer - hands down one of the most accomplished scientists I know. This is a prime example of how we can/should leverage cutting-edge technology to improve patient care. @labs_mann @ErnstLengyel #precisionmedicine x.com/labs_mann/stat…
Matthias Mann Lab@labs_mann

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…

English
1
0
11
579
Lisa Schweizer
Lisa Schweizer@LisaCSchweizer·
I’m thrilled to share that the main work of my PhD has been published @Cancer_Cell! With @labs_mann & @ErnstLengyel, we analyzed the progression from ovarian serous borderline tumors to invasive cancer using spatial proteo-transcriptomics and identified new therapeutic targets.
Matthias Mann Lab@labs_mann

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…

English
9
8
30
2.1K
Lisa Schweizer retweetledi
Marvin Thielert
Marvin Thielert@marvinchth·
Happy to share our preprint in collaboration with the Lundberg Lab revealing spatial heterogeneity in human pancreatic islets with multiplexed Deep Visual Proteomics. Grateful for the fantastic team and collaboration!
Matthias Mann Lab@labs_mann

Excited to share our preprint on multiplexed DVP! mxDVP extends CODEX to DVP family, revealing spatial heterogeneity in human pancreatic islets with 12 endocrine sub-types including rare polyhormonal cells. Fantastic team effort @Prof_Lundberg #LundbergLab biorxiv.org/content/10.110…

English
0
1
10
215

Keşfet

@MPI_biochem @Cancer_Cell @OvCa_UChicago @uchicago_obgyn @labs_mann @MPI_Biochem @Nature @AndrasPiffko