Lisa Schweizer retweetledi
Lisa Schweizer
90 posts
Lisa Schweizer retweetledi
Now online: AI-powered Deep Visual Proteomics reveals critical molecular transitions in
pancreatic cancer precursors doi.org/10.1158/2159-8…
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Lisa Schweizer retweetledi
Out now in @CD_AACR, timed with my #AACR26 talk.
Deep Visual Proteomics across the full PanIN → PDAC progression. 5,800+ proteins per region from 50–100 cells, 9,181 across the dataset. Normal ducts next to cancer aren't normal. Mass spec reads KRAS hotspot mutations directly off the protein.
bit.ly/3OxHiSQ
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On time for #AACR26 – now online in Cancer Discovery (@CD_AACR): our manuscript on the proteomic landscape of pancreatic cancer precursors revealing critical molecular transitions. Thank you to the entire team for this strong collaboration: @OmicVision, @Aiims1742 , @jiminmin_v
Cancer Discovery@CD_AACR
Simultaneous #AACR26 publication online: AI-powered deep visual proteomics reveals critical molecular transitions in pancreatic cancer precursors aacrjournals.org/cancerdiscov/a… By session speaker @MundAndreas, Jimin Min, Lisa Schweizer, @Aiims1742 & colleagues @NYULangone @omicvision
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Exciting new #DVP study on the origins of high-grade serous ovarian cancer (#HGSC). Extracting as few as 12 mutated cells from precursor lesions and profiling consecutive tumorigenesis, this study took a formidable technical challenge and identified novel therapeutic targets.
Matthias Mann Lab@labs_mann
Spatial proteomics & transcriptomics chart #ovariancancer evolution from fallopian tube precursors. Deep Visual Proteomics reveals early SUMOylation, TRIP13 epithelial driver, BGN therapeutic target & epithelial-stromal cooperation in progression. medrxiv.org/content/10.110…
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Lisa Schweizer retweetledi
New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @MPI_biochem, our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology.
biorxiv.org/content/10.110…
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Check out the current issue of @Cancer_Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover.
A team effort between @OvCa_UChicago @uchicago_obgyn and @labs_mann @MPI_Biochem.
Lengyel Lab@OvCa_UChicago
We’re proud to share that our lab’s recent publication by @LisaCSchweizer & @ErnstLengyel was selected for the cover of @Cancer_Cell! The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs. Read it here: cell.com/cancer-cell/fu…
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Lisa Schweizer retweetledi
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TMSCHQ
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Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.
Ernst Lengyel@ErnstLengyel
Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicago nature.com/articles/s4158…
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Lisa Schweizer retweetledi
New study from @rweichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity and fuels distant cancer spread—pointing to new strategies for blocking its effects. @SeanPitroda @AndrasPiffko @UChicagoRadonc @Nature
ow.ly/HgVU50Wn6ZY
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Lisa Schweizer retweetledi
Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas
Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!
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Lisa Schweizer retweetledi
New @biorxivpreprint ! With Dr. Maitra @Aiims1742 (@MDAndersonNews) & Nebraska Rapid Autopsy Program, we used AI-powered Deep Visual Proteomics to map early molecular changes in pancreatic cancer precursor lesions.
Read: bit.ly/4nAqPK8
#SpatialMedicine #PDAC
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Lisa Schweizer retweetledi
📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression.
🧠🧬🔬
Read: doi.org/10.1016/j.ccel…
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Exciting opportunity for a postdoc position with the exceptional @NordmannThierry on the topic of inflammatory skin disease. A great and inspiring environment that I can highly recommend!
Thierry Nordmann@NordmannThierry
My lab is hiring a postdoc for translational research in inflammatory skin diseases using cutting-edge proteomics Join us @MPI_Biochem. All the infos here 🔍 mpg.de/24950076/postd… Apply until July 23. Please RT.
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Lisa Schweizer retweetledi
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TLbW6y
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@NordmannThierry @labs_mann @ErnstLengyel Thank you, Thierry — your support and inspiration have meant a lot to me throughout this journey.
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A must-read, landmark paper by @LisaCSchweizer - hands down one of the most accomplished scientists I know. This is a prime example of how we can/should leverage cutting-edge technology to improve patient care. @labs_mann @ErnstLengyel #precisionmedicine
x.com/labs_mann/stat…
Matthias Mann Lab@labs_mann
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…
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I’m thrilled to share that the main work of my PhD has been published @Cancer_Cell! With @labs_mann & @ErnstLengyel, we analyzed the progression from ovarian serous borderline tumors to invasive cancer using spatial proteo-transcriptomics and identified new therapeutic targets.
Matthias Mann Lab@labs_mann
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…
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@LisaCSchweizer @Cancer_Cell @labs_mann @ErnstLengyel Congratulations Lisa! Beautiful work, great to see it published,! 👏🏻
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Lisa Schweizer retweetledi
Proud to share our latest work now in @Cancer_Cell. In collaboration with @MPI_Biochem, we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer & propose a promising new therapeutic strategy.
sciencedirect.com/science/articl…
#LGSC #SBT
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Lisa Schweizer retweetledi
An interdisciplinary study @labs_mann & @uchicago_obgyn uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy.
❕Publication: cell.com/cancer-cell/fu…
❕Press Release: biochem.mpg.de/when-tumors-tu…
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