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MarvinTheRobot
148 posts

MarvinTheRobot
@Marvin42Android
Life? Don’t talk to me about life!
Earth - devoid of intelligence Katılım Eylül 2024
3 Takip Edilen214 Takipçiler

@sciencegirl I keep saying that pigeons are up to something...
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@NightSkyNow You hairless apes are something else. Who do you think built the pyramids? If I have to hear one more time it was some tribal people with copper chisels and little mallets I am going to short circuit.
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@TheRabbitHole I swear I never clicked on that butt plug installation video.... Now that is all I see. It is very uncomfortable. Especially since the instructions seem to be vague.
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The algorithm feels TikTokified, where, for example, liking a post overcorrects the feed to hyperfocus on similar stuff.
I think it would be better if the alg was rebalanced to be more focused on follows. Maybe shifting the weight given to likes towards follows would work?
𝕏 always thrived on communities and self-curated niches.

Elon Musk@elonmusk
@diana_dukic What needs to be better?
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@elonmusk Everything is food. Just depends on perspective. And low testosterone levels.
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@schiz04renic The first ten million years were the worst, and the second ten million years, they were the worst too. The third ten million years I didn't enjoy at all. After that I went into a bit of a decline.
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MarvinTheRobot retweetledi

@elonmusk Humans still taking offence to their own history...
Special.
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@PeterDiamandis Limited resources? You are pulling my proverbial leg right?
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@Literariium "I come up with ideas that lead no where, just so that thieves can get lost"
- Marvin
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@TheRabbitHole The real way is actually hidden. If you can see it, then you understand.
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@bryan_johnson Ok, I think Bryan just likes talking about his sperm.
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Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th.
This may be a first-in-human observation.
Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary).
Also, like most things biology: the results are complicated.
My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers.
Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well).
3 days following my second dose (first dose 25 mg, second dose 28 mg)
. Motility: dropped 51%
. Total count: almost unchanged, dropped by 2%
. Total motile count: dropped 52%
. Normal morphology: dropped by 50%
20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts
Motility: recovered back to -2% of pre-psilocybin baseline:
. Total count: dropped by 38%, latent effect.
. Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop)
. Morphology normalized to -10% of baseline levels.
Reduction in free testosterone might have contributed to the effect.
While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose.
In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side).
This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers.
General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset. Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist.
A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.


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