Mark

There's an old joke in systems biology called "How Biologists Fix a Radio." A biologist, tasked with figuring out why a radio doesn't work, removes components one by one and catalogs the result. Remove this transistor: the radio makes a horrible screeching sound. Conclusion: this is the "horrible screeching transistor." Remove another component: the radio goes silent. Conclusion: this is the "silence transistor." This is essentially what we do with genomics. We see which genes are mutated in cancer and assume they must be "cancer genes." We see which genes are differentially expressed and assume they must be "important." But correlation is not causation, and a parts list is not a circuit diagram. You can have a complete inventory of every resistor, capacitor, and transistor in a radio and still have no idea how it plays music.

Sacubitril-Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: Primary Results of ANSWER-HF Randomized Trial In patients with CCC and HFrEF, sacubitril-valsartan did not result in significant improvements in LVEF compared with enalapril after 6 months, but was associated with a greater reduction in NT-proBNP. No safety concerns were associated with either the sacubitril-valsartan or enalapril group #Cardiology #MedTwitter #CardioTwitter #HeartHealth #Healthcare @JACCJournals @ACCinTouch @hfcollaboratory @hvanspall @SJGreene_md @gcfmd @AndrewJSauer @dranulala @DrMarthaGulati @ShelleyZieroth @Hragy @biljana_parapid

> 600,000 left atrial appendage devices have been placed NOT NONINFERIOR 👇🏻 Trial is large, nonindustry funded and done in experienced centers in Germany Endpoint had both efficacy and safety components and still did not make non-inferiority I tried to tell you all

Real…

We have reached peak AI. Someone made an entire short film "Harry Potter by Balenciaga" Credit: demonflyingfox on YT

My faith in guideline recommenders of the west has diminished.. open.substack.com/pub/sensibleme…

@DrAkhilX Every doctor will have three “personal” cemeteries. The first will consist of patients we could have saved but didn’t (including our own mistakes). The second will be those whom it was not in our power to save.And the third will include everyone else — because no one is immortal

Expose the dark side of Medicine.

@JamieMetzl China is not stupid. They are unlikely to start aggression in the near future. On the contrary, China’s actions around Taiwan right now are more likely aimed at tying down U.S. and allied forces in the region to prevent them from moving closer to Iran.

My concern: China is waiting for the U.S. to exhaust itself in the Middle East and pull our military out of position—then escalate in the Taiwan Strait and South China Sea. The time for the U.S. and its allies to prepare and deter is now, not after Beijing makes its move.

@MohammedAlo @PenelopeFigtree @bmorecardiology @drjohnm @hopkinsheart @rblument1 Absolutely. Most cases of diabetes that appear during statin therapy are essentially a statistical effect caused by borderline prediabetes crossing the diagnostic threshold due to a small increase in HbA1C of about 0.1%–0.4%.

@Matarener @PenelopeFigtree @bmorecardiology @drjohnm @hopkinsheart @rblument1 Are you agreeing with me?

Im not sure I understand why CAC = “may withhold statins” — LDL = atherosclerosis — CAC = calcified plaque (not soft) — why not drive down LDL early and forever… what is harm in this strategy, and why do we need CAC? @drjohnm @hopkinsheart @rblument1

@MohammedAlo @PenelopeFigtree @bmorecardiology @drjohnm @hopkinsheart @rblument1 Base

@PenelopeFigtree @bmorecardiology @drjohnm @hopkinsheart @rblument1 Statins don't cause new diabetes. Only if you already have the genetics for diabetes, there's a small chance it may get worse. Only 3% of those or less. Also it's a small change in A1c, only 0.1% but comes with a 50% reduction in MACE.

@drjohnm In this regard, the latest ESC guidelines are much simpler: there are several main treatment strategies that are easy to remember and that cover both primary and secondary prevention (including diabetes, chronic kidney disease, and familial hyperlipidemia)

Lipid guidelines contains 14 management flow charts How is a gen cardiologist or primary care doc supposed to be guided by such a document? Should be 3-4: prim prevention, sec prevention, diabetes and maybe special circumstances (FH or TG > 300) It's not that complicated

This weekend, i am going to follow OpenMed! ❤️ huggingface.co/OpenMed

@three_cube Are you serious? They already know — even from the public map of nodes, Moscow has more nodes than many European capitals.

If the citizens of Moscow had built a meshtastic network, they would still be able to communicate.

@RinoTheBouncer RimWorld

What game is this?🚀

@leecronin When you read the comments under this post, it really becomes scary for the future of humanity. With such a low level of overall intelligence, AI could indeed replace everyone — not because AI is so smart, but because people are becoming dumber and turning into degenerates.

Using chatgpt & alpha fold to make a cancer vaccine makes no sense on so many levels but of course everyone will believe it.

“97% of depression in young men is caused by lack of money” rich people: “money doesnt buy happiness”

I don’t know folks… @x journal club is pretty top flight. Drug Coated Balloons non inferior to Drug Eluting Stents? Not so fast.