Matthew K Garr
16.9K posts

Matthew K Garr
@MatthewKGarr
UNCG ‘19 UNC Med ‘26 Duke Internal Medicine ‘29 ? Allergy/Immunology ‘?
Katılım Şubat 2012
628 Takip Edilen3K Takipçiler

@ihatethiskid Many signs of a cultured man in this screenshot. Following the nba game on the island? 😮💨😮💨
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@DiorIzzy Wouldn’t that first one be amazing!! Thanks for the reply
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@MatthewKGarr @BradSpellberg @DrToddLee @ABsteward 1) Duration of therapy for PJI stratified by type of joint, type of surgery and type of organism. Coz I don’t think DATIPO answered that question. 2) Is amp+CRO really needed for E faecalis IE (I believe Dr Lee’s group is going to do this trial.
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If typical limitations didn’t apply in this hypothetical scenario, what would be your top few prospective RCT’s you would like to see done someday? Even if not “feasible” what big questions would it be nice to have answered?
@BradSpellberg @DrToddLee @DiorIzzy @ABsteward
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Matthew K Garr retweetledi

The Duke Department of Medicine welcomes its 2026 class of interns to the Internal Medicine, Preliminary Medicine, Medicine-Pediatrics and Medicine-Psychiatry programs.
Find out who will be joining us!
#MatchDay #DukeIM #MedEd
@N04/albums/72177720332645893/" target="_blank" rel="nofollow noopener">flickr.com/photos/1980657…

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@i_realnih Is this tweet and the replies all bots?? Of course this is legal wtf
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@Kansanparantaja @MohammedAlo This is at 5 years, arguably very short. Do you have patients on statins for 5 years only? The benefit hardly even accumulates until after 1-2 years and continues growing.
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The NNT for statins is 7.
Dr. Ammous@AmmousMD
If you look at absolute risk reduction (ARR) numbers for statins: You need to treat more than 200 people for 5 years to prevent one heart attack. This comes at the expense of serious side effects, including diabetes, liver injury, muscle breakdown, brain fog, and dementia.
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@docxusofficial Docs don’t know about alpha gal? Maybe it’s the UNC training in me (high prevalence, Alpha gal research here) but I’m very surprised, this is like #1 on the differential for allergic reaction occurring a few hours after ingestion.
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A new allergy is spreading across the US and most doctors have never heard of it
A 47 year old walked into the ER in feeling faint with swollen eyelids, an itchy rash, and 3 weeks of watery diarrhea after every meal.
For the past 5 days the diarrhea had progressed to crampy abdominal pain, nausea, and vomiting.
His HR was high. BP was low. Hives across his scalp, neck, shoulders, abdomen, and groin. Lips swelling.
Then his blood pressure crashed.
> white cell count massively elevated
> lactic acid high indicating poor tissue perfusion
> troponin elevated suggesting cardiac stress
> procalcitonin elevated suggesting possible infection
> kidney function declining
They pumped 4 litres of IV fluids. Blood pressure came back. Heart rate stayed high.
Then it crashed again.
2 more litres. Antibiotics. H2 blockers. Glucocorticoids. Then 10 more litres. He was moved to the ICU on epinephrine.
Blood and urine cultures came back negative. Not sepsis.
By day 3 he was improving. Rash fading. Pain settling.
Then on day 4 it all came back. Chest tightness. Difficulty breathing. Worsening rash. Tachycardia. Hypotension. Oxygen dropping. Wheezing.
Epinephrine rescued him again almost immediately.
His bloodwork from day 1 finally returned. Elevated IgE. Elevated tryptase. This was mast cell driven anaphylaxis.
Something was triggering a massive allergic response. But to what?
He had no new medications. No new foods. No known allergies. No travel.
Then someone asked what he ate 4 hours before the day 4 flare.
Beef
He also mentioned he had eaten venison (meat from a deer) 2 days before the original ER visit. And that he is a deer hunter who had recently been hunting white tailed deer in southeastern Michigan.
He had alpha-gal syndrome.
Alpha-gal is a carbohydrate found in all nonprimate mammals.
Humans don’t naturally have it.
But if you get bitten by a lone star tick that has previously fed on a deer or other mammal the tick’s saliva introduces alpha-gal into your bloodstream.
Your immune system produces IgE antibodies against it.
And now every time you eat red meat your body treats it as a foreign invader and launches a full allergic response.
The reaction is delayed by 3 to 6 hours after eating which is why it’s so hard to connect to food. Most allergies hit within minutes. Alpha-gal waits. That delay is what made this case so difficult to crack.
The lone star tick used to be confined to the eastern and southeastern United States.
It has now spread into the upper Midwest, the Northeast, and eastern Canada.
The cause is climate change. Warmer temperatures. Shifting precipitation. Expanding habitats for both the tick and the white tailed deer it feeds on.
Alpha-gal syndrome cases in the US have surged from near zero to over 110,000 suspected cases in the last decade.
Most physicians have never seen one. Many don’t even know it exists
Climate change isn’t just about rising sea levels and wildfires.
It’s changing which diseases show up in your doctor’s office.
And if your doctor isn’t thinking about it you might end up in the ICU for eating a BURGER

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@BradSpellberg @DrToddLee @ABsteward Thank you. You have helped me to think beyond the Guidelines shmidelines once again
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Outpt CAP w/ Comorbidities. Does DM alone really warrant two antimicrobials? IDSA says Amox-clav/Cefpodoxime + Doxy/Azith or levo.
Just wondering if the evidence is there for otherwise well diabetic patients?
@BradSpellberg
@DrToddLee
@ABsteward
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@rissaoffline Hahaha I really miss joke twitter so much. I came off private just to ask this question. Life is great! Married and have an 8 month old girl now :) i hope life is great for you!!
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@MatthewKGarr it's so funny seeing your tweets and remembering ur a doctor now. hope ur doing well man!
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@NeKit69YT @ArcRaidersNow And if they don’t successfully defend it as a community they lose that map for 2 weeks
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Matthew K Garr retweetledi

@LizzieZ2024 You are deeply asocial and worried about stuff that isn't real. You've convinced yourself that a bunch of stuff is happening that isn't actually happening, and you are using this paranoid fantasy to justify ruining not only other people's lives, but ultimately your own as well.
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Matthew K Garr retweetledi
Matthew K Garr retweetledi

Too early to establish causation, but autoimmunity after EBV and probably other viruses that we previously thought to be "benign" is likely one of the major mechanisms of autoimmune disorders. Unfortunately, our society is not into infectious disease prevention so... 😷
Eric Topol@EricTopol
Now the potential role of Epstein Barr virus for driving lupus science.org/doi/10.1126/sc…
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