Walid Mawass

Our latest preprint finds that a shortage of beneficial mutations does more to drive small populations extinct than mutational meltdown does. Explainers elsewhere @MawassWalid @JosephMatheson2 @Uliseshmc @JeremyJBerg doi.org/10.1101/2024.1…

SAVE THE DATE ➡️💻 On September 10, at 3:00 p.m. EDT, current representatives will answer your questions about the program and application in a webinar! Register now: bit.ly/3yUtGZU Join Anvita Kulshrestha, @PravruthaRaman, & @MawassWalid!

Join us September 10, at 3:00 p.m. EDT for a webinar featuring current ECLP representatives Anvita Kulshrestha, @PravruthaRaman, & @MawassWalid. They will answer questions about the Early Career Leadership Program & the application! Register now: bit.ly/476PBcX

@arguablywrong @JosephMatheson2 @gcochran99 @cremieuxrecueil Have to keep a sensible amount of humor when working with something like github.

@MawassWalid @JosephMatheson2 @gcochran99 @cremieuxrecueil Cool! Also, this made me laugh. But seriously, thanks for publishing on arxiv and github and chatting about it with me. Best traditions of academic research 👍

Wow! Great work from @JosephMatheson2! TL;DR: If this holds, contrary to Kondrashov's suggestion that we ought to be dead 100 times over, mutational load accumulation due to increasing paternal age or relaxed selection might not be as much of a dysgenic risk as once thought.

@JosephMatheson2 @arguablywrong @gcochran99 @cremieuxrecueil ...instead of increase in fixation of deleterious mutations (i.e. mutational meltdown). We found that it mostly depends on the mean of the DFE of the beneficial mutations. We are also looking into running sims with pops crashing from 10K to 1K for ex.

@JosephMatheson2 @arguablywrong @gcochran99 @cremieuxrecueil Yeah, I've been looking at the case in small population sizes, so less < 10k. I do find evidence that there are realistic regimes where a decreasing population is driven into a mutation-driven extinction vortex due to a shortage of beneficial (compensatory) mutations...

Next Twitch stream just dropped! Come hang out at 3 p.m. tomorrow with us and @MawassWalid

@SashaGusevPosts You should make comic strips with these Sasha!!

1990: "We estimate the heritability of crime at 140% with -60% environmental variance; a dominance model provided the best fit. Paradoxically, twins raised apart were more likely to be partners in crime than twins raised together, a phenomenon we term the Granthom effect."

@Graham_Coop Thanks Graham for this important thread!

A new paper claiming a simple model of genetics fit a range of social traits. It’s interesting data, but it’s a massive reach to say the model fit reflects genetic effects, as there’s no control for environment here. 1/n

@vsbuffalo Good thread Vince! As you've said, a correlation that varies with genetic relatedness is not evidence of genetic cause given that this correlation can be both transient and do some environmental or demographic processes. Plus, testing non-genetic models for fit with data matters.

On the Clark paper: correlation functions often decay over various distances (genetic, environmental, spatial, etc). Observing a correlation that varies over genetic relatedness is not evidence that the cause is genetic, since many other processes create correlations that decay.

@sauve_drew Excellent, Drew! I'll be there!

@nashintasapaino @JimCostaHBS I also enjoyed this talk so much! Great way to start #Evolution2023

I'm riveted by @JimCostaHBS' plenary talk about "teaching Darwin with Darwin" at #evol2023. His enthusiasm and deep knowledge of Darwin's bizarre experiments, like seeing whether snails will climb on to severed duck feet or feeding toenails to carnivorous plants, are infectious.

@LukeAnderTroc Congrats Luke! Great work!!!

My PhD work "On the Genes, Genealogies, and Geographies of Quebec" is now published in SCIENCE!!🧑‍🔬 🌎We explore the emergence of genetic variation in Quebec's settler population with a detailed model using a genealogy of 5M records. 🔗science.org/doi/10.1126/sc… 🧵for details : 1/7

@sauve_drew Congrats Drew! Can't wait to check out your work.

@DrMikeWiser You could never go wrong with a PC given the games you cited.

Hivemind: What gaming system should I get if I mostly like games along the lines of Civilization and single player non-MMO RPGs? I don't play first person shooters, tower defense, racing games, or anything that requires coordinating a game with others (particularly guilds).

@pastramimachine Have you heard him on the Liquid Tension Experiment? The man is crazy!

chapman stick anyone?

@pastramimachine Going to have to wait to see what the Supreme Court thinks of this first!

Ban matrix multiplication

Hi community, reaching out for help. At @GeneticsGSA ECLP, we're onto something (curtain-raiser soon!) Plz tell us abt your favorite scientist (academia/industry) who is an inspiring leader. Someone who could spill secrets of leadership for community Tag them here/DM me RT plz

@rlmcelreath @vsbuffalo Great point to bring up!

@vsbuffalo Bayes obeys the likelihood principle as a logical consequence. There is no conflict with Bayes here. It's classical frequentism that has argued against the "law of likelihood". Jaynes page 250. We can do *better* by using priors. But no one is confused except philosophers?

Richard Royall on the law of likelihood: "evidence has a different mathematical form than uncertainty. It is likelihood ratios, not probabilities, that represent and measure statistical evidence".

@pastramimachine I need a pre-order as well when you get it set up!

My new zoom setup