McKinsey Lab

We enjoyed writing an editorial about an interesting new paper in @CircRes .  Check both out! ahajournals.org/doi/10.1161/CI…; doi.org/10.1161/CIRCRE…; Marion Delaunay @12Zegeye @CUCardiology

Happy to announce Collin Wells and Nathan Witmer as the newest postdoctoral fellows in our group. Collin joins us from the U of Louisville (trained with Bradford Hill) and Nathan is a recent graduate of the U of Iowa (trained with Ryan Boudreau). Welcome Collin and Nathan!

Congratulations to Dr Natalie Gehred on her AMAZING PhD defense: Cardiac Fibroblast Heterogeneity and Epigenomic Regulation in Heart Failure @UCLAAnes @UCLAMBI @UCLA @dgsomucla

3 weeks into the new editorial board for JACC BTS, the JACC family member for basic and translational discoveries! Please consider JACC BTS for your manuscripts. We do fast, friendly and fair peer review. Because life is short and science is fast ⚡️❤️‍🔥🧠

Amazing @CircRes Compendium on Interorgan Crosstalk, organized and edited by @mkontari and @gabrieleschiat1. The potential to manipulate fat-heart crosstalk for therapeutic purposes is enormous. Check out our take! ahajournals.org/doi/full/10.11…

Special thanks to Issei Komuro and the amazing organizing committee for a fantastic meeting #ISHR2025 Nara. The bar has been set very high for future ISHR meetings. Congratulations to postdoctoral fellow Marion Delaunay for giving an invited lecture and winning a poster award!

UAB at ISHR 2025: Fantastic science, amazing friends, beautiful location! @UABHeersink @UABPathology @UABCardiology @TheWendeLab

Our first foray into using AI to tackle human cardiac fibrosis. ahajournals.org/doi/full/10.11…. Amazing collaboration with @gwaybio and waysciencelab.com. Spearheaded by @JoshTravers89 and @jenna_tomkinson. Tip of the iceberg. Stay tuned!

#HFpEF Summit 2025 - another year, another success. Grateful for all speakers, attendees and sponsors! @VCUHealthHeart @SmidtHeart @LeferLab

Heart rate matters. Great collaboration with Mike Bristow and many others. Clinical trial, endomyocardial biopsies, new molecular mechanisms of reverse remodeling in the human heart. ahajournals.org/doi/epub/10.11…

Check out this job at University of Colorado Anschutz Medical Campus: linkedin.com/jobs/view/4179…

@jsauce7 @PNASNews @tayloreggertsen @JoshTravers89 @MattWolfMDPhD Great collaboration and looking forward to expanding it going forward! Powerful computational approaches for dissecting disease mechanisms and discovering new therapeutic approaches for heart failure.

Happy to share our paper, "Logic-based machine learning predicts how escitalopram (LexaPro) attenuates cardiomyocyte hypertrophy" in @PNASNews, with @tayloreggertsen with @JoshTravers89, @McKinseyLab, & @MattWolfMDPhD. Validated in cells, mice & patients. pnas.org/doi/10.1073/pn…

Please mark your calendar for this exciting scientific event on July 07-09, 2025 at the University of Manitoba!

Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues @Joseph_C_Wu, @sadayappanlab and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models jci.org/articles/view/…

Excited to share our latest paper in #EHJ, led by talented postdoc Yue Yuan (who is x-less). @BCM_CVRI @dr_dobrev @BCMDeptMedicine @ehj_ed @ESC_Journals Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis academic.oup.com/eurheartj/arti…

This week, we celebrated the investiture of our Director, Dr. Hesham Sadek, as the Lovaas Endowed Chairholder, and Associate Director, Sakthivel Sadayappan, PhD, as the Lopez Endowed Chairholder. The future of cardiovascular medicine starts at Sarver!

Thank you @ajpheartcirc for publishing our recent work on BRD4 in cardiac macrophages. Huge effect on MHC-II levels. doi.org/10.1152/ajphea…. Great team effort and collaboration with many, including @VagnozziRJ and @m_alexanian.

#UTSW research led by Elizabeth Chen, Ph.D., uncovers the actin protein’s pivotal role in cellular processes, offering new insights into cancer research and targeted therapies. Learn how this discovery could shape the future of treatment: bit.ly/40Lzw9X #CancerResearch

A muscle patch developed using stem cells can help to repair failing hearts without adverse effects, according to a paper in @Nature. go.nature.com/4hdbfRf