Melanie Rodriguez

Fun working on this review @JournalCancer about #belzutifan with @TambarLab who were involved in its development and @QianJanieQin @KCPUTSW @UTSWMedCenter pubmed.ncbi.nlm.nih.gov/41632099/ acsjournals.onlinelibrary.wiley.com/doi/epdf/10.10…

You’re going to love this mechanism! Prof. Dirk Trauner reported this amazing reaction cascade as part of an eight-step synthesis of epicolactone. What is the mechanism of the reaction? Courtesy of grad student @SwapnamoyGangu1

Our lab started a new activity #ClassicsFriday! We’re going through Classics in Total Synthesis (Nicolaou and Sorensen) chapter by chapter. This week we discussed Corey’s groundbreaking synthesis of the Prostaglandins (1969): pubs.acs.org/doi/10.1021/ja… What’s your favorite classic total synthesis?

Happy birthday to postdoc Melanie Rodriguez @Mel_1090 !

Grad student Tiffany Brisco @Tiffany05Brisco gave a great talk at group meeting on good habits for Scientific Record Keeping. @UTSWGradSchool @UTSWScience @UTSWMedCenter

We enjoyed hosting our friend Joe Fox @FoxGroupUD @UDelaware for a seminar during our joint 2025 Chemistry-Biology Interface T32 Symposium between @UTSWMedCenter and @UMich! Thanks Grad student Lauren Duncan @ledwards31 for organizing the event.

Check out our recent paper in @J_A_C_S on the diastereoselective synthesis of morpholines! Congratulations @Tiffany05Brisco! @UTSWMedCenter @UTSWScience @UTSWGradSchool

Our lab recently discussed the amazing career of Matthew S. Sigman @UtahChemistry. Here are some papers: onlinelibrary.wiley.com/doi/abs/10.100… pubs.acs.org/doi/10.1021/ar… nature.com/articles/natur… science.org/doi/10.1126/sc… pubs.acs.org/doi/10.1021/ja…

Our lab recently discussed the illustrious career of the late Amos B. Smith, III @PennChemistry @JOC_OL. Here are some papers: pubs.acs.org/doi/10.1021/ol… pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ac… mdpi.com/1999-4915/15/5…

Happy Holidays from the Tambar Lab!

Our lab discussed the career of Dean @Toste_Group @UCB_Chemistry. Here are some papers: pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ja… nature.com/articles/natur… pubs.acs.org/doi/10.1021/ac…

David Spiegel reported this oxidative cyclization for the total synthesis of the marine alkaloid (±)-dibromoagelaspongin. What is the mechanism of the reaction? Courtesys of Postdoc @Mel_1090

In Group Meeting we discussed the career of Phil Baran @BaranLabReads @scrippsresearch. Here are some papers that lab members selected: pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ja… science.org/doi/10.1126/sc… nature.com/articles/s4158…

The venerable Robert K. Boeckman developed this elegant ring expansion for the total synthesis of (+)-Laurenyne. What is the mechanism of the reaction? Courtesy of graduate student @callmefortuNate

Happy birthday graduate student Lauren Duncan @ledwards31 !

Louis Barriault reported this cool reaction in his total synthesis of Arteanniun M. What is the mechanism? @thebarriaultlab It's trickier than you think. Pay attention to the “chirality transfer of the tandem process.” Courtesy of grad student Rene Garcia Del Valle.

Happy Birthday graduate student Nate Schmitt @callmefortuNate ! @UTSWGradSchool

Latest work is out today as a 'HOT Article' in @ChemicalScience! @RebeccaKehner & @CO2PERATE_ESR13 @BaylorCBC use Zr-catalysis to convert esters to imines & aldehydes, enabling new strategies for polyester depolymerization. Our group's #myfirstrchemsci: doi.org/10.1039/D4SC05…

Thank you @MilliporeSigma for sponsoring the annual Aldrich-UTSW Excellence in Chemistry Symposium! Great talks from Liela Romero, John Wood, and Jet Tsien! @Liela_Romero @JohnWoodGroup @JetTsien @QinLab @UTSWMedCenter @UTSWScience @BaylorCBC @UTSWGradSchool

In 1996, Dennis Curran developed beautiful cascade radical reactions with isonitriles for the synthesis of (20S)-camptothecin. What is the mechanism of this reaction? Courtesy of graduate student Lauren Duncan @ledwards31