Mesh Lakhani

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Mesh Lakhani

Mesh Lakhani

@Meshlakhani

Co-Founder & CEO, Interlock Labs | Making healthcare AI deployable and insurable.

NYC Katılım Mart 2009
1.1K Takip Edilen2.3K Takipçiler
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Hubert Thieblot
Hubert Thieblot@hthieblot·
Never quit as a founder. I’m begging you. It’s 0 for longer than you’ll ever expect. No momentum. Soul-crushing doubts. Nobody seems to care. Even when it looks like it’s working, it’s not. You keep trying new things. You don’t lose hope. Then it snaps to 100. You finally find the one thing that resonates. You wake up with more customers than you can handle. Everything is breaking. Momentum keeps building even when you’re not pushing. Something changed. You didn’t get lucky, you just didn’t leave.
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Mesh Lakhani
Mesh Lakhani@Meshlakhani·
@zmwang You’re so great at this. Would love to see some of your recipes that involve multiple people assisting and working together. Dumplings, etc.
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Mike Wang
Mike Wang@zmwang·
I'm writing a cookbook for connection and launching the first recipes → cookbookforconnection.com For 15+ years I've been the friend people texted at 11 pm before a big life thing. "I'm walking into my first board meeting tomorrow, how do we build trust in the first 10 minutes?" "I'm designing my 35th, help me make it more than a bar night." "I'm going on a trip with my parents, how do we actually connect?" "We're designing our intercultural wedding, how do we make it magical and not formulaic?" 🍽️ They each wanted a "recipe" for how to design an experience. I'm sharing some of the meaningful ones that helped them (ingredients, steps, and a little science explaining why it works). 👨‍👩‍👧 What I learned is that people wanted to connect with the most important people in their lives, but were stuck. Holidays with parents, date night with their partner, a cousin's trip, a team offsite, a birthday, a baby shower. We default to the same script and wonder why the night felt okay but not great. It's usually not a lack of love in the room. It is a lack of inspiration about how. 🍚 In the same way you pull up a food recipe when you want to cook something great for someone, I believe we need inspiration from recipes for the experiences we host. Magical recipes to teach people how to host, facilitate, and create the "vibes". I will share a new recipe every Monday (cookbookforconnection.com). Comment 👇: What recipes would you want to read? Who do you want to deepen connection with in your life?
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Michael Burry Stock Tracker ♟
Michael Burry Stock Tracker ♟@burrytracker·
And it begins Sullivan & Cromwell just admitted to a federal judge its court filings contained AI hallucinations The firm apologized to the federal judge as they had to submit multiple corrections focused around: • Fictitious Case Names: The filing included names of legal cases that do not exist • Fabricated Quotes: The document contained direct quotes that were never actually spoken or written • Non-existent Statutes: The AI incorrectly analyzed or entirely invented provisions within the U.S. Bankruptcy Code The primary team and secondary review all failed to catch these errors, meanwhile the firm's partners bill $2,000+ per hour
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Ankur Nagpal
Ankur Nagpal@ankurnagpal·
Carry has been acquired by Angellist and Lettuce We started this company 3.5 years ago to help business owners make better financial decisions These two transactions allow us to continue to do this important work in a bigger way Thank you to everyone who supported us ❤️
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Will Ahmed
Will Ahmed@willahmed·
You have no experience. You’ve never started a company. You’ve never had a full time job. Nike is going to kill you. You’re a kid. You don’t have technical skills. You shouldn’t build hardware. Apple is going to kill you. You can’t build hardware. You can’t measure heart rate non-invasively. Athletes don’t care about recovery. Under Armour is going to kill you. It won’t be accurate. You don’t listen. You’re an ineffective leader. You can’t recruit great talent. You’re going to have to pay every athlete. You can’t measure sleep non-invasively. It’s too expensive to research. Athletes are a small market. The product costs too much to make. The product costs too much to sell. Your valuation is too high. Consumers aren’t going to want it. Hardware is too hard. You should measure steps. Fitbit is going to kill you. You can’t build a marketing engine. You can’t raise enough money. You need a real CEO. Google is going to kill you. You can’t be a subscription. You can’t build a brand. You can’t do consumer in Boston. Your valuation is too high. You shouldn’t make accessories. You shouldn’t make apparel. Lululemon is going to kill you. You can’t predict Covid. Stay in your niche. You are going to run out of money. You can’t build a health platform. Amazon is going to kill you. You can’t measure blood pressure. You can’t get medical approvals. The market is too small. You don’t understand AI. The market is too competitive. It won’t work internationally. The supply chain is too complicated. You can’t build an AI. You can’t raise enough money. It’s too competitive. Healthcare isn’t going to want it. … Just keep going ✌️
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Mesh Lakhani
Mesh Lakhani@Meshlakhani·
I’ve tried every dental appliance. While it works for periods of time it does shift your bite and can be dramatic over time. I ended up going back to a cpap machine and while super annoying at first, I’d never go back. I go everywhere with it. I was diagnosed about 15 years ago.
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Ankur Nagpal
Ankur Nagpal@ankurnagpal·
An update here in case it helps anyone else with sleep apnea: I got a custom oral appliance built (like a dental retainer that you sleep with) and my symptoms are at least 95% better Huge quality of life upgrade
Ankur Nagpal@ankurnagpal

Just got diagnosed with moderate to severe sleep apnea Would love to know anyone that has successfully cured this with lifestyle interventions etc. No overweight / general metrics and health pretty good, would not have noticed this if not for a test at a longevity clinic

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Mesh Lakhani
Mesh Lakhani@Meshlakhani·
This framework really applies to healthcare AI. The data needed to make clinical AI insurable (failure data) can't be generated without IRB approval and institutional access that takes years to build. Once it exists it compounds. But the elapsed time to get started is the actual moat.
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Peter Girnus 🦅
Peter Girnus 🦅@gothburz·
I bought Rivian stock on IPO day. November 10, 2021. $172 a share. I bought 58 shares. That was $9,976. I remember the exact number because my girlfriend asked what I spent ten thousand dollars on and I said "the future of transportation." She said "you drive a 2017 Civic." I said "exactly." $1,000 invested at IPO is now worth $149.06. I have that number memorized. I check it before coffee. I check it after coffee. I check it during meetings where I'm supposed to be listening. The number changes by pennies. The pennies matter to me now. The thesis was simple. Rivian was the next Tesla. They had the Amazon delivery vans. They had the adventure truck. They had the factory in Normal, Illinois. I told people the factory was in a town called Normal. I thought that was meaningful. A sign. The future of transportation, built in a place called Normal. The factory produced 24,337 vehicles in its first full year. Tesla produced 1.8 million. I called that "room to grow." I have been through six theses on Rivian. Thesis one: they're the next Tesla. (Stock dropped 40%.) Thesis two: the Amazon vans are the real play. (Amazon cut the order.) Thesis three: the R2 platform will be the mass-market breakthrough. (Delayed 18 months.) Thesis four: the Georgia factory changes everything. (Paused indefinitely.) Thesis five: Volkswagen's $5 billion investment validates the technology. (Stock kept falling.) Thesis six: Uber robotaxis. This is the pivot. Every time the stock drops, I find the new thesis. I don't look for it. It finds me. I open Reddit. I open the Rivian subreddit. Someone has written a post titled "Why this is actually bullish." It has 400 upvotes. I read it. I agree with it. I was going to agree with it before I read it. The agreement is the point. The DD is the prayer. My cost basis is $172. The stock is $14.06. I am down 91.8%. I could have bought a used Rivian R1T with the money I've lost on Rivian stock. I have not done the math on this. I'm doing it now. Yes. I could have bought one. A 2022 with 30,000 miles. I would have the truck AND the remaining money. I drive a 2017 Civic. My coworker Dave bought index funds. Dave is up 34% over the same period. Dave brings a sad lunch to work every day. Turkey sandwich. Same sandwich. Dave will retire at 65 with a comfortable nest egg and a lifetime of turkey sandwiches and he will never know what it felt like to be early. I am early. I have been early for four and a half years. At some point early and wrong have the same return on investment. But they feel different. Wrong feels like a mistake. Early feels like a strategy. I feel like a strategy. The Uber partnership was announced Tuesday. I texted three people. One was my brother. One was a guy from the Rivian subreddit whose real name I don't know. One was my girlfriend. My ex-girlfriend. She stopped asking about Rivian in 2023. She stopped asking about anything in 2024. The stock jumped 10%. It gave half back the same day. But for eleven minutes I was only down 81% instead of 85%. I called that momentum. I took a screenshot. I still have the screenshot. Rivian will build robotaxis for Uber. Rivian has not built a profitable vehicle for anyone. Rivian lost $38,784 on every vehicle it delivered last year. That's not my number. That's their 10-K. But I don't think about it that way. I think about it as investment in scale. Scale means you lose money faster until you don't. Uber needs thousands of autonomous vehicles. Rivian needs to not go bankrupt before 2027. These are complementary needs. That's a partnership. That's synergy. That's the pivot. Dave asked me yesterday how much I'm down. I said "I'm long-term." He said "it's been four years." I said "Tesla was down 80% once." He said "Tesla was also profitable once." Dave went back to his sandwich. Dave doesn't understand pivots. I bought more shares this morning. This is the pivot.
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Mesh Lakhani
Mesh Lakhani@Meshlakhani·
Great share. One pushback on your clinical AI defensibility thesis. You identify the evaluation gap but conclude vertical AI companies will own it by validating against their own patient populations. Two problems with that. No vertical company will openly catalog its own behavioral failures because that data is discoverable in litigation. And even if they did, insurers need comparative failure data across systems and specialties to build actuarial models, not one company’s self-reported numbers. Independent verification under research protections like an IRB solves both. Generates the data without the liability, across enough systems to actually price the risk.
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Emre Karatas
Emre Karatas@EmreTKaratas·
We are open-sourcing our investment hypotheses because the best ideas in healthcare benefit from pressure-testing out in the open. Check out the first 3 here → virtuevc.com/writings More hypotheses to come and feedback is welcome!
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Mesh Lakhani
Mesh Lakhani@Meshlakhani·
@omooretweets Patient safety is one thing. But it’s more of a liability risk for the company producing the patient facing AI. That needs to be solved for before it can really scale and serve everyone in a meaningful way. Ie- needs to be insurable.
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Circe
Circe@vocalcry·
Everything is perfectly clear. Iran could not be allowed to get a nuclear weapon, which they have been months away from developing for well over a decade. Also, Trump is the only president who could have kept us out of war with Iran, as he himself repeatedly told us. So we destroyed their nuclear capabilities, which Tulsi said they didn't have, in 2025. Then we attacked them last month because Israel was going to attack them because they were months away from developing a nuclear weapon since we destroyed their nuclear capabilities, and that would lead Iran to attack American bases. Iran has never posed a threat to the United States, but we had to attack them first, not because of Israel, but because they posed an imminent threat to the United States. Fortunately, we have won the war, which was not a war but a special operation, in Iran now several times in the last two weeks. It is basically over but might not be over for some time because we already won. We also don't need anyone to help open the Strait of Hormuz, which we knew they would close, which is why we didn't prepare, and we now need allies to help open. What are you guys not understanding?
Karoline Leavitt@PressSec

There are many false claims in this letter but let me address one specifically: that "Iran posed no imminent threat to our nation."   This is the same false claim that Democrats and some in the liberal media have been repeating over and over.   As President Trump has clearly and explicitly stated, he had strong and compelling evidence that Iran was going to attack the United States first.   This evidence was compiled from many sources and factors. President Trump would never make the decision to deploy military assets against a foreign adversary in a vacuum.   Iran is the world’s leading state sponsor of terrorism. The Iranian regime is evil. It proudly killed Americans, waged war against our country, and openly threatened us all the way up to the launch of Operation Epic Fury.   Iran was aggressively expanding their short-range ballistic missiles to combine with their naval assets to give themselves immunity – meaning they would have a degree of a capabilities that would give them immunity to hold us and the rest of the world hostage.   The regime aimed to use those ballistic missiles as a shield to continue achieving their ultimate goal – nuclear weapons.   The President, through his top negotiators, gave the regime every single possible opportunity to abandon this unacceptable course by permanently giving up their nuclear ambitions in exchange for sanctions relief, free nuclear fuel, and potential economic partnerships with our country.   But they would not say yes to peace because obtaining nuclear weapons was their fundamental goal.   President Trump ultimately made the determination that a joint attack with Israel would greatly reduce the risk to American lives that would come from a first strike by the terrorist Iranian regime and address this imminent threat to America’s national security interests.   All of this led to President Trump arriving at the determination that this military operation was necessary for U.S. national security, which is why he launched the massively successful Operation Epic Fury. The Commander-in-Chief determines what does and does not constitute a threat, because he is the one constitutionally empowered to do so - and because the American people went to the ballot box and entrusted him and him alone to make such final judgments. And finally, the absurd allegation that President Trump made this decision based on the influence of others, even foreign countries, is both insulting and laughable. President Trump has been remarkably consistent and has said for DECADES that Iran can NEVER possess a nuclear weapon. As someone who actually witnesses President Trump’s decision-making process on a daily basis, I can attest to the fact that he is always looking to do what’s in the best interest of the United States of America — period. America First.

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juan
juan@juanbuis·
the new ferrari interior design by jony ive and lovefrom is absolutely stunning *this* is what an apple car could've looked like
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Noel Smith
Noel Smith@NoelSmith·
Explaining options to people for the first time:
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▼ Kiel James Patrick
As a kid I thought the Bermuda Triangle was gonna be a much bigger problem in my adult life
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Toni Gemayel
Toni Gemayel@tonigemayel·
That was fast. From our very first conversation it was clear that we shared a vision for where prediction markets are going and that Coinbase + Clearing would be a formidable fit. I can think of no better venue to bring regulated prediction markets onchain.
Brian Armstrong@brian_armstrong

Last week: prediction markets launch on Coinbase. This week: we bring in the team that helped make prediction markets what they are today. Just getting started.

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The Figen
The Figen@TheFigen_·
The patterns of trigonometry.
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Peter Girnus 🦅
Peter Girnus 🦅@gothburz·
Last quarter I rolled out Microsoft Copilot to 4,000 employees. $30 per seat per month. $1.4 million annually. I called it "digital transformation." The board loved that phrase. They approved it in eleven minutes. No one asked what it would actually do. Including me. I told everyone it would "10x productivity." That's not a real number. But it sounds like one. HR asked how we'd measure the 10x. I said we'd "leverage analytics dashboards." They stopped asking. Three months later I checked the usage reports. 47 people had opened it. 12 had used it more than once. One of them was me. I used it to summarize an email I could have read in 30 seconds. It took 45 seconds. Plus the time it took to fix the hallucinations. But I called it a "pilot success." Success means the pilot didn't visibly fail. The CFO asked about ROI. I showed him a graph. The graph went up and to the right. It measured "AI enablement." I made that metric up. He nodded approvingly. We're "AI-enabled" now. I don't know what that means. But it's in our investor deck. A senior developer asked why we didn't use Claude or ChatGPT. I said we needed "enterprise-grade security." He asked what that meant. I said "compliance." He asked which compliance. I said "all of them." He looked skeptical. I scheduled him for a "career development conversation." He stopped asking questions. Microsoft sent a case study team. They wanted to feature us as a success story. I told them we "saved 40,000 hours." I calculated that number by multiplying employees by a number I made up. They didn't verify it. They never do. Now we're on Microsoft's website. "Global enterprise achieves 40,000 hours of productivity gains with Copilot." The CEO shared it on LinkedIn. He got 3,000 likes. He's never used Copilot. None of the executives have. We have an exemption. "Strategic focus requires minimal digital distraction." I wrote that policy. The licenses renew next month. I'm requesting an expansion. 5,000 more seats. We haven't used the first 4,000. But this time we'll "drive adoption." Adoption means mandatory training. Training means a 45-minute webinar no one watches. But completion will be tracked. Completion is a metric. Metrics go in dashboards. Dashboards go in board presentations. Board presentations get me promoted. I'll be SVP by Q3. I still don't know what Copilot does. But I know what it's for. It's for showing we're "investing in AI." Investment means spending. Spending means commitment. Commitment means we're serious about the future. The future is whatever I say it is. As long as the graph goes up and to the right.
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