Will Shaw

The paper has many more insights that I hope will help make plant transformation easier and more predictable. biorxiv.org/content/10.648… And we’ll make the plasmids available through Addgene as ASAP! Huge thanks to everyone involved in @MoKhalilLab and Mary Gehring labs!! 16/16

Beyond Arabidopsis, we believe this work establishes an important, outcome-focused framework for the rational, host-optimised design of next-generation T-DNA vectors, providing a foundation for more predictable and efficient plant transformation across diverse species. 15/16

New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @MoKhalilLab + Gehring labs biorxiv.org/content/10.648… 🧵1/16

Come and join us at a free complementary Japan-UK Engineering Biology meeting after the main ESSL conference (essl2025.org). A few spaces left to some see some of the up and coming superstars of #synbio in the UK!

Genome engineering excelled at small nucleotide changes, but large edits remained challenging. Recent innovations are changing this. We reviewed the field of structural variant engineering @NatureGenet 🧬 @JulianeWeller @TVanderstichele @LeopoldParts nature.com/articles/s4158…

Our paper: "A history-dependent integrase recorder of plant gene expression with single-cell resolution" is published in @NatureComms . Congrats Cassandra Maranas for completing this work! @EarlhamInst @UWBiology To read the paper: rdcu.be/dYxtF nature.com/articles/s4146…

Job alert: 2 postdoc positions available in my group @EarlhamInst. Synthetic biology to 1) decode and engineer root architecture, 2) engineer plant-beneficial rhizobacteria. Reach out and please share! earlham.ac.uk/scientific-gro… 1) jobs.earlham.ac.uk/Details.asp?va… 2) jobs.earlham.ac.uk/Details.asp?va…