@thelowcarb_rd No worries, yeah I just think that data is underestimating the effect of GLP-1 when used as indicated for weight loss.
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Morgan Pfiffner
2.8K posts
Morgan Pfiffner
@MorganPfiffner
MS in nutrition. I write about food and health. Editor-In-Chief of Study Summaries at https://t.co/OIdcfEaXr5. Contributor for https://t.co/0jARFor9JI.
The PNW Katılım Ocak 2015
176 Takip Edilen1.1K Takipçiler
Why is my inclusion criteria odd?
and tbh since this is social media and not a peer reviewed publication, I did not set out a formal inclusion criteria. I read the first study then tried to find similar data for low carb at a one year mark and decided to compare and contrast outcomes.
I've indicated as clearly as possible where these studies differ.
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Nobody is saying not to use the drugs, but why is low carb labelled as "extreme" when the one year outcomes are similar to the drugs, minus the side effects?
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#Food #inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food?
sciencedirect.com/science/articl…
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@TheBhupiThakur @heniek_htw Yep. Here's a summary of my main issue with the dietary inflammatory index (DII):
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@heniek_htw I remember morgan also doesn't like this index @MorganPfiffner
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@JasonKPargin Also, "It's what it's" is functionally the same phrase but sounds completely ridiculous.
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An important lesson in language is that the phrase “It is what it is” logically seems to convey zero information but it’s one of the most useful phrases we have
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@HermanPontzer @BioLayne @kurzgesagt Enough power for what? The study was only powered to detect a 10% increase in total energy expenditure.
So I don't think this study is a strong test of whether exercise energy expenditure is fully compensated for.
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@MorganPfiffner @BioLayne @kurzgesagt Within-subjects like here would have enough power, but in any case it’s not unique. Other interventions (but not all! Not claiming that) have similar results
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Exercise doesn’t help you lose fat?
Usually @kurzgesagt does a great job breaking down topics but in this case, while he is right with parts of it, certain context is missing and there is also over interpretation of the constrained energy expenditure model presented here
Please allow me to assist
Comment ‘FINISH STRONG’ and I’ll DM you info on how to get 20% off Biolayne coaching, this week ONLY 👇
Edit: they removed the original video & appear to have updated their thoughts. KUDOS!!!
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@HermanPontzer @BioLayne @kurzgesagt Since this non-randomized study only had 11 participants, isn’t a likely explanation for a lack of statistical significance that it had limited statistical power?
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@BioLayne @kurzgesagt Good break down, but of course we controlled for body size in the Hadza work. Also see (Hadza aren’t unique in this): pubmed.ncbi.nlm.nih.gov/33454748/
And many controlled exerc intervention show no stat sig increase in total expend, e.g.
pubmed.ncbi.nlm.nih.gov/1443128/
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In a new randomized controlled trial, skipping breakfast did not clearly worsen mood, sleepiness, or cognitive function in teenagers (13–15 y/o) when compared to regular low-GI breakfast (w/ or w/o nitrate supplementation).
nature.com/articles/s4153…
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@theproof Also, I feel it's not being highlighted that (based on Nick's prev reported lipid levels) his LDL would have been around 300 mg/dL after the diet, which doesn't seem to exonerate (egg-onerate?) eggs imo.
fwiw I eat 3 eggs/day, but recognize it's not a black/white issue.
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I stand pretty firm here. Nick's egg experiment is not shocking. It's not something leading cardiologist's who are part of the cardiology guidelines would be surprised by.
The basic physiology that underpins dietary cholesterol absorption has been well understood for decades.
People are confused about eggs and dietary cholesterol absorption because they do not understand this physiology and n=1 experiments like Nick's, without appropriate education, only increase that confusion (as evidence by the number of inaccurate tweets about what Nick's experiment shows).
Simon Hill MSc, BSc@theproof
I didn't ask if it would higher than eating eggs + carbs. The simple question is: Does dietary choelsterol influence serum cholesterol? 1 - YES, by about 15% or so if your baseline cholesterol intake is close to 0mg per day. 2 - No, not by much (except for hyper absorbers) if you already have a background diet of 300-400mg of dietary cholesterol per day. This doesn't seem debatable at this point. It seems like basic scientific principles that people should understand when considering this question. If it's left out, the information and 'story' is incomplete.
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A new study analyzed a single dataset on red meat and mortality 1,208 different ways
In an article for @Examinecom, I discuss why researchers did this, what it tells us about epidemiology, and why it doesn't tell us much about red meat and health.
examine.com/research-feed/…
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This crossover trial found that a vegan diet, but not a Mediterranean diet, substantially reduced people's estimated intake of advanced glycation end products (AGEs).
I think the jury is still out on the harms of AGEs, but interesting data nonetheless.
pubmed.ncbi.nlm.nih.gov/39176029/
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@richcollins @sguyenet So they cite one promising study but it didn't specifically investigate remission
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Lots of spicy responses to this review, but no evidence-based critiques.
As always, the review is very detailed, with quotes, page numbers, and many citations.
Disagreement is OK but knee-jerk reactions that don't engage with the review don't advance the conversation.
Red Pen Reviews@redpenreviews
We just published our review of "The Diabetes Code" by Dr. Jason Fung. It claims to offer a revolutionary way to reverse type 2 diabetes. But does it live up to the hype? Let's break down our review! redpenreviews.org/reviews/the-di…
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@willeybrown777 @redpenreviews "Nothing factual"
From the review: "The dietary recommendations in The Diabetes Code will likely help people with or at risk of T2D to lose weight and control their blood glucose levels"
So you don't think that's factual, interesting.
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We just published our review of "The Diabetes Code" by Dr. Jason Fung. It claims to offer a revolutionary way to reverse type 2 diabetes. But does it live up to the hype? Let's break down our review! redpenreviews.org/reviews/the-di…
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@richcollins @sguyenet Disagrees with the claim that T2D remission rates are rarely investigated.
Then doesn’t cite any studies investigating T2D remission rates.
Make it make sense.
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Steven M. Belknap, MD PGY43@StevenMBelknap
Steer clear of @redpenreviews, the nutrition review site spearheaded by @sguyenet. Red Pen reviews just panned @drjasonfung's book, 'The Diabetes Code.' According to the Red Pen Reviewer(s), "Low-carbohydrate diets have been shown to lower HbA1c and the use of glucose-lowering medications versus control diets, but T2D remission rates are rarely investigated." Somehow, the reviewer(s) missed hundreds of relevant peer-reviewed articles mentioned by Dynka et al. DOI 10.3390/nu15030500 The reviewer(s) go on to cherry-pick one study, "One low-carbohydrate intervention study has shown some success with T2D remission at 1 and 2 years of follow-up (17–26% of adherent patients); however, these were people with a lot of additional professional support and most did not achieve T2D remission." IThe best RCT by Saslow et al. compared Very Low Carb (VLC) & DASH diets with or without multicomponent extra support. VLC bested DASH for lowering blood pressure, Hgb A1C & body weight. Extra support didn't matter. In the Saslow RCT, 38% of the VLC group stopped or reduced their diabetes drugs compared to 0% of the DASH group. DOI 10.1370/afm.2968 Ignore Red Pen Reviews. Their reviews are fraudulent or incompetent or both.
QME
Morgan Pfiffner retweetledi
🔎New study out from our Dartmouth team! 🔍
🧬Genetics interact with cue reactivity!🧬
onlinelibrary.wiley.com/doi/10.1111/ij…
"Each FTO risk allele was associated with a 30% increase in [intake]... Food cue exposure exacerbated associations between the FTO variant with gummy candy [intake]."
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@r55414771 @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan “The deceleration started long before Covid”
That doesn’t appear correct from the data I’ve seen
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@MorganPfiffner @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan Covid accelerated the downward trend. But the deceleration started long before Covid was released.
The amount of metabolic dysfunction and diabetes and obesity is ever increasing and starting earlier in life. Doesn’t portend well for future chronic disease and health.
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Seed Oils: Friend, Not Foe!
Don't fear seed oils. They're rich in omega-6 fatty acids, which support heart health. Focus on cutting ultra-processed foods, not these healthy fats. My take with @American_Heart: bit.ly/4fYd6sF
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@r55414771 @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan Reversal of longer lifespan trend in US around 2020 was primarily due to Covid and increase in overdose deaths, so it’s of questionable relevance to seed oil (it’s not like we suddenly started eating seed oils in 2020)
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@MorganPfiffner @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan Trend of longer lifespans decelerated and has been dropping recently. It’s the first time in modern US history that the offspring have not been doing as well as their parents. Financially, family formation, health, lifespan.
And with the explosion of T2DM in kids >it’ll be worse
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@r55414771 @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan You’re painting with too broad a brush, in the past 50 years lifespans have generally gotten longer and age adjusted rates of some major diseases like CVD and Alzheimer’s have either gone down or remained constant.
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@MorganPfiffner @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan And further, looking around, many people are getting sicker and sicker.
That portends an explosion of not only diabetes, but also cardiovascular, cancer, obesity and Alzheimer’s, mental health and all other chronic diseases that arise from worsening metabolic health.
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@r55414771 @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan Ok thanks for sharing
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@MorganPfiffner @StevenMBelknap @dylanarmbruste3 @GardnerPhD @American_Heart @drcateshanahan It’s the leading cause of death in the US, still. With cancer in respectable second place.
Sometimes adjusted means manipulated to tell a lie.
heart.org/en/news/2019/0…
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