Elaine

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Take too much Ozempic, and your brain stops wanting things: food, sex, even the urge to get out of bed. People end up in hospital beds for days, staring at the ceiling, feeling nothing. The medical name for that state is anhedonia, and it tells you how the drug actually works. Ozempic, Wegovy, and Mounjaro all belong to the same drug family, called GLP-1s. They kill hunger. They also quiet almost every other craving your brain produces. Inside your brain there is a small region that makes a chemical called dopamine. Dopamine is your brain’s “this is worth wanting” chemical, the reason you reach for one more bite of pasta, refresh your inbox one more time, or pick up your phone every few minutes. GLP-1 drugs reach that region and turn the dopamine down. The right dose dampens the loudest craving first: food. Take too much, and the volume drops on everything else, sex, exercise, work, even the urge to get out of bed in the morning. Anhedonia is the medical name for not feeling pleasure from anything at all. It looks identical to deep depression. The good news is that anhedonia from GLP-1s has an off switch: once the drug clears your system, the wanting comes back. The FDA has logged over 1,150 reports of bad reactions tied to compounded GLP-1s through July 2025. These are custom-mixed versions made by smaller pharmacies. In many of those cases, patients accidentally took five to twenty times their prescribed dose. The cause is usually confusion between milliliters and units when measuring out a dose with an insulin syringe, since compounded versions come in plain vials instead of the pre-filled pens that brand-name Ozempic uses. About 15 million Americans currently use a GLP-1, roughly one in eight adults. Around 75% of them eventually quit. Cost and side effects are the top reasons. A growing number describe a third reason that patients call “the lights dimming,” a flat, gray feeling across the whole day that doctors now recognize as anhedonia caused by the drug itself. This same mechanism has caught pharma’s attention. Eli Lilly is now running two large clinical trials with a combined 2,200 patients to see if a GLP-1 drug can treat alcohol addiction. The bet is that the same brain switch that turns off cravings for food can also turn off cravings for alcohol, cocaine, nicotine, and gambling. A 2026 psychiatry review put it bluntly: doctors should be treating these as psychiatric drugs, because that is what they have turned out to be. The drug works by quieting your brain’s signal that something is worth wanting. A normal dose turns the volume down on food cravings. Push the dose too high, and everything else goes quiet too.

I know a few teachers in Queens who would beg to differ.

i know we're already way beyond the pale, but in any normal society, this should be pitchforks and torches type stuff

This is why the shift to everyone hating each other has been so hard for millennials. Many of us went to diverse schools where everyone basically got along. Sure, jokes were made & bad people existed, but there was a general code of respect. Social media + rage bait ruined that

Fun Fact : Rihanna gave Drake his first #1 with "What's My Name" and it was her 8th #1 at the time. Years later she gave him his second #1 with "Work", making it her 14th #1 overall.

A lot of abusive people rely on social likability because society struggles to believe harm can come from charismatic individuals.

Men can openly follow porn stars, thirst over random women online, and call it “normal male behavior.” But if a woman openly finds men attractive or has standards, suddenly she’s “shallow” and “for the streets.” The double standard has always been obvious.

There aren’t adequate words to properly express the depth and scale of trump’s corruption, it’s completely on a scale of its own with no historical equivalent to point to.

Being physically present at church is good for my mental health.

The fathers of Davion & Rashad Murphy — brothers David and Winston Murphy — are also serving life sentences for the 2008 murder of 26-year-old Timothy Jones, same as their sons, who were recently sentenced to life for ambushing and killing Charles Jones, aka Julio Foolio.

Not to sound geriatric but...you know what i miss? Turning something on and it just works. No account setup. No app download. No QR code. No "sign in to continue". Just plug it in and it does the thing its supposed to do.

What’s not genuine won’t survive around me and I love that.

Yes, actually, we do accommodate them. We recruit rural physicians for rural communities all the time because people are more likely to trust and stay connected to healthcare systems when clinicians understand their culture, language, geography, and lived experience. That is why we have rural tracks in medical schools, Native health pathways, Black maternal health initiatives, Spanish-speaking clinics, VA systems, tribal health systems, and community-based recruitment programs. This is not “woke.” It is how public health works. The difference is that nobody calls it “identity politics” when medicine bends over backward to accommodate rural White populations because that has long been viewed as normal. The outrage only seems to appear when minority communities ask for the same recognition. Patients are human beings, not interchangeable widgets in a bureaucratic sorting machine.

Reminds me of when men broke the fingers of a sex robot, molested it and heavily soiled it at a tech fair. It's not about whether the robot has feelings, it's about how these men get so excited about harming something when they know there are no consequences.

with age and experience u can spot a loser a lot quicker. which is why losers love dating young

It effectively illustrates that you could not commit a mass shooting with technology from the 18th century

I disagree with the Department of Justice going after Yale School of Medicine over DEI admissions policies and arguing that objective metrics like GPA and MCAT scores should dominate admissions decisions. The evidence does not support the idea that standardized test scores alone identify the best physicians. The MCAT predicts performance on other multiple-choice exams reasonably well. What MCAT scores do NOT predict are clinical judgment, communication, bedside skill, or physician performance. Put another way: doctors who test well tend to do well on examinations. But test scores do not predict how well they care for patients in clinics, hospitals, surgery, or real-world medicine. Meanwhile, more diverse physician workforces are associated with better preventive care, greater trust, improved access, and lower mortality in underserved communities. There is no objective evidence that excluding minority applicants within a reasonable score range improves patient outcomes. We need minority physicians in this country, and we have the data to prove why. So when people insist that “objective measures” alone should determine admission into medicine — while ignoring the evidence about what actually improves patient care — I increasingly see that argument as less about merit and more about preserving exclusion under the comforting language of statistics. "Equality feels like oppression to those who are privileged"

George H.W. Bush kept his assets in a blind trust, as did Bill Clinton. Neither Obama nor Biden traded stocks or bonds while in office. 3,700 trades is probably more than all the trades of all the presidents until now. And he is trading stocks that are affected by his decisions. A walking conflict of interest, at the least, and perhaps insider trading. Just as members of Congress should not be able to trade stocks, so too the president. bloomberg.com/news/articles/…