Laurent Nguyen

🎉 Happy to share our latest work! Congratulations for the fantastic achievement @fanny_lepiemme ⁦@CarlaGSilva1⁩ ⁦@miriam_jt⁩ ⁦@StouffletJ⁩ with help from ⁦@MazzuGabi⁩ science.org/doi/10.1126/sc…

Systematic scRNA-seq screens profile neural organoid response to morphogens. @TreutleinLab @ETH_BSSE @naturemethods nature.com/articles/s4159…

ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development dlvr.it/TPWHtx

New in @Nature, @LabNowakowski & team use barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. nature.com/articles/s4158… #studyBRAIN

Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids dlvr.it/TP2y1m #stemcells

Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L96tu0Ctj…

New preprint from the lab! We discovered transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to surface expansion in humans 1/ doi.org/10.1101/2025.1…

New preprint showing human brain organoids from our library of patient #IPSCs modeling neurodevelopmental disorders. Four major clinical classes of NDDs (MIC, EPI, PMG, ID) showed distinct scRNAseq and organoid phenotypes. doi.org/10.1101/2025.0…

Intercellular communication in the brain through a dendritic nanotubular network | Science science.org/doi/10.1126/sc…

Human brain organoids record the passage of time over multiple years in culture | bioRxiv biorxiv.org/content/10.110…

@neuroliege is redefining how we think about Mechanotransduction shapes distinctpatterns of neuron migration during cerebral cortex development. #cellmech2025

@angoffinet De côté c’est ça?

Au bord du gouffre, n'hésitons pas à faire ensemble un grand pas en avant!

@LukeChaoSun @ERC_Research @dandrite @MolBiolAU @NordicEMBL @erin_schuman @PoulNissen @RangarajuVidhya @YiZuoUCSC @anna_schroed @SilviaTrchtt @aviveki_vivek Congratulations!!!

We just received @ERC_Research Starting Grant!- 'we' meaning lab members @dandrite @MolBiolAU @NordicEMBL whose hard work contributed, & my mentor @erin_schuman and friends @PoulNissen @RangarajuVidhya @YiZuoUCSC @anna_schroed Haiyan He, Jelena Radulovic whose wisdom inspired!

@BenschZimmer Hey congratulations for this nice story!

🧠 Our new study is out in Nature Communications! DNMT1 regulates the migration of cortical interneurons, with implications for cortical layering and function — and potentially neuropsychiatric conditions. 🔗 doi.org/10.1038/s41467… Huge thanks to the amazing team/collaborators!

Our latest work is out today in @ScienceMagazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by @massimo_onesto with Neal Amin

10/10 Here’s the paper @CellCellPress if you want to dig in cell.com/cell/fulltext/… That’s it. Thanks for sharing! @dev_neuro @MRC_CNDD @KingsIoPPN @wellcometrust

We are hiring! Interested in infection biology, immunology, microbiology? Funded postdoctoral position in our lab at Institut Pasteur research.pasteur.fr/en/team/biolog… research.pasteur.fr/en/job/funded-… @institutpasteur @Inserm Contact us at postdoc.biu@pasteur.fr

🚨 We are thrilled to announce our amazing list of keynote speakers!! @PCusachs @GeorgHalder @hirashima0203 @dagmarIber @johannaivaska @gijsjekoenderi1 @neuroliege @renkawitzteam @Sixt_Lab @VickySanzMoreno Kit Parker @EdouardHannezo @creinhartking @WickstromLab @MEmilieTerret

The Sensory Transduction and Nociception Group @painchannels at @NeuroAlc offers a 1-year (extendable to 3) postdoctoral position. The call is open until position is filled. More info 👇 in.umh-csic.es/en/ofertas/1-y…