Laurent Nguyen

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Laurent Nguyen

Laurent Nguyen

@neuroliege

Scientific director and PI at GIGA Institute, University of Liège 🇧🇪 - personal views

Liege, Belgium Katılım Mart 2018
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Cell Reports
Cell Reports@CellReports·
ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development dlvr.it/TPWHtx
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Cell Stem Cell
Cell Stem Cell@CellStemCell·
Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids dlvr.it/TP2y1m #stemcells
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Joseph G. Gleeson
Joseph G. Gleeson@jogleeson_ucsd·
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L96tu0Ctj…
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Miki Ebisuya
Miki Ebisuya@EbisuyaMiki·
New preprint from the lab! We discovered transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to surface expansion in humans 1/ doi.org/10.1101/2025.1…
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Joseph G. Gleeson
Joseph G. Gleeson@jogleeson_ucsd·
New preprint showing human brain organoids from our library of patient #IPSCs modeling neurodevelopmental disorders. Four major clinical classes of NDDs (MIC, EPI, PMG, ID) showed distinct scRNAseq and organoid phenotypes. doi.org/10.1101/2025.0…
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CellMech2025
CellMech2025@cellmech2025·
@neuroliege is redefining how we think about Mechanotransduction shapes distinctpatterns of neuron migration during cerebral cortex development. #cellmech2025
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Geraldine Zimmer-Bensch
Geraldine Zimmer-Bensch@BenschZimmer·
🧠 Our new study is out in Nature Communications! DNMT1 regulates the migration of cortical interneurons, with implications for cortical layering and function — and potentially neuropsychiatric conditions. 🔗 doi.org/10.1038/s41467… Huge thanks to the amazing team/collaborators!
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Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Our latest work is out today in @ScienceMagazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by @massimo_onesto with Neal Amin
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