Neurology Nuggets

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Neurology Nuggets

Neurology Nuggets

@NeuroNuggs

Quick tips to improve your own neurological health and practice. Your daily dose of neuro. And maybe some crypto…

Katılım Temmuz 2025
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Neurology Nuggets
Neurology Nuggets@NeuroNuggs·
Why Neurologists Are Ignoring Ibogaine’s Potential — At Their Peril (And why patients with tremor, Parkinson’s, TBI, and addiction are already moving without us) Most neurologists still react to ibogaine like it’s 1995: “Cardiotoxic Schedule I plant medicine — stay far away.” Meanwhile, in late 2025: - Stanford published 88% full PTSD remission in Special Forces veterans after one magnesium-ibogaine session (Nature Mental Health, July 2025) - Texas just committed $50 M of state money to ibogaine research - Conor McGregor is telling 60 M followers it reset his brain - Multiple sclerosis patients are returning from clinics with visible lesion reduction on follow-up MRIs The specialty is getting left behind. Fast. Here’s what’s actually happening in the brain 👇 Ibogaine doesn’t just “block opioids.” It triggers a massive, multi-week surge of GDNF and BDNF in the VTA and prefrontal cortex — forcing adult neurogenesis and synaptic remodeling that dwarfs anything we currently have in clinic (TMS, tDCS, ketamine included). For tremor & Parkinson’s: It normalizes pathological beta oscillations and restores theta rhythm coupling — the exact deficits that drive rigidity and tremor. For TBI & concussion: Single dose markedly improves functional connectivity in default mode and salience networks for months. Addiction: Resets dopamine transporter density to pre-addiction levels in 24–48 hours. Nothing else on earth even comes close. The cardiac risk everyone cites? Essentially eliminated when magnesium is co-administered (Stanford protocol). QTc prolongation drops to negligible levels — safer than many antipsychotics we prescribe daily. Yet the average academic response remains: “Wait for Phase 3 data.” Phase 3 won’t exist until 2030+ because Big Pharma can’t patent a plant. By then patients will have treated themselves in clinics from Tijuana to Cancun to Malta to Gabon. I’m not saying everyone should book a flight tomorrow. I’m saying we now have enough mechanistic and real-world evidence that dismissing this molecule outright is rapidly becoming indefensible. As a neurology provider who lives in neurotech (tDCS, TMS, photobiomodulation, EEG-guided protocols), I can tell you this: Properly integrated ibogaine is the single biggest leap I’ve seen in years for tremor, rigidity, brain fog, and addiction. The future isn’t “ibogaine OR conventional neurology.” It’s ibogaine + neurologist-guided pre/post integration using the tools we already have. The doctors who figure this out first will own the next decade of brain medicine. If you’re a clinician scared of this molecule — get informed. If you’re a patient suffering — you now have options most doctors won’t mention for another 5–10 years. Not medical advice. Just data most neurologists are pretending doesn’t exist. Who’s ready to stop ignoring the obvious? 🔥
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MrBeast
MrBeast@MrBeast·
If this tweet has exactly 1 like in 24 hours I’ll give that person $1,000,000
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CharizardEats
CharizardEats@CharizardEats·
Someone talk me out of paying scalper prices for one…
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Cobb
Cobb@Cobb_XRPL·
What’s the most you have ever paid for a singular XRP token?
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Meowth Prince
Meowth Prince@MeowthPrince·
Is this peak Meowth?✨️
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Knoyhead
Knoyhead@knoyhead·
Weekly post asking for proof of one single actual living human successfully getting something from a Walmart Pokémon Card drop
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Totodile King
Totodile King@totodile_king·
What’s your craziest eBay pickup? Mine was in 2024 when someone listed two PSA 9 Magikarp IRs as “Magicarp”.
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Neurology Nuggets
Neurology Nuggets@NeuroNuggs·
🧠 Neurology Nuggets | 5-MeO-DMT: Phase 2b Data Dropped The “God Molecule” is making serious waves in clinical research and with @bryan_johnson. Here’s the latest: ⚡ What is it? 5-MeO-DMT acts as a serotonergic agonist at 5-HT1A and 5-HT2A receptors. Inhaled, onset hits in ~5–10 seconds with effects lasting just 5–30 min — making it one of the fastest-acting psychedelic candidates in development. 🔬 GH Research Phase 2b (Feb 2025) — TRD This is the headline result. In a randomized, double-blind, placebo-controlled trial of 81 TRD patients, GH001 (inhaled 5-MeO-DMT) achieved a placebo-adjusted MADRS reduction of -15.5 points by Day 8 (p<0.0001), with a 57.5% remission rate vs. 0% in the placebo group. No serious adverse events were reported. Long-term data is equally striking: the open-label extension confirmed a 73% remission rate at 6 months with infrequent treatment visits and no mandated psychotherapy, and 100% of double-blind patients continued into the extension phase. GH Research is now seeking FDA alignment on a global Phase 3 pivotal program. 💊 Beckley Psytech Phase 2a (May 2025) — TRD + SSRIs A single dose of BPL-003 (intranasal 5-MeO-DMT), given adjunctively with SSRIs, produced rapid and lasting antidepressant effects for up to 3 months, with patients discharged in under 2 hours on average. Their Phase 2b study — the largest controlled trial of 5-MeO-DMT ever, with 196 patients across 38 sites in 6 countries — completed enrollment in March 2025. 🍺 New frontier — Alcohol Use Disorder Beckley’s Phase 2a trial of BPL-003 in alcohol use disorder showed meaningful and sustained reductions in alcohol use for up to 3 months post-dose, with no serious or severe adverse events. ⚠️ Still early days A 2024 systematic review in Frontiers in Psychiatry notes that while 5-MeO-DMT is emerging as a potentially rapid-acting antidepressant, its safety and tolerability must be reported meticulously given its early stage of development. Phase 3 data and long-term safety studies are still needed. The future looks bright. 📚 Sources: ∙GH Research press release, Feb 2025 (investor.ghres.com) ∙Beckley Psytech press release, May 2025 (beckleypsytech.com) ∙Marsden et al., Addiction 2025 (doi: 10.1111/add.70260) ∙Kwaśny et al., Front. Psychiatry 2024 (doi: 10.3389/fpsyt.2024.1477996) ∙Reckweg et al., Front. Psychiatry 2023 (doi: 10.3389/fpsyt.2023.1133414) #Neurology #Psychedelics #5MeODMT #TreatmentResistantDepression #NeurologyNuggets
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Neurology Nuggets
Neurology Nuggets@NeuroNuggs·
@trevorgmillar @ambio_life I really appreciate your honesty and candor. A lot of big success numbers are being thrown around, and while Ibogaine is certainly life changing, it still takes work on the other side of the journey. Thanks for all you and the team are doing.
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Neurology Nuggets retweetledi
Robin Carhart-Harris
Robin Carhart-Harris@RCarhartHarris·
Been applying to her office and others (eg welcome trust, nimh, arpa) for years asking to test/demonstrate that this isn’t magical thinking or snake oil. Glad to see things might change.
Psychedelic Alpha@Psyched_Alpha

Speaking at the signing of a psychedelics-focused executive order on Saturday, NIDA Director Nora Volkow shared how her view of psychedelic therapy has changed over the past decade. More: psychedelicalpha.com/news/president…

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Neurology Nuggets retweetledi
Trevor Millar
Trevor Millar@trevorgmillar·
What is Ibogaine?
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Grant Cardone
Grant Cardone@GrantCardone·
Money doesn’t buy happiness, but…. (Finish what I’m thinking for $500….)
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Neurology Nuggets
Neurology Nuggets@NeuroNuggs·
To my fellow healthcare providers, if you do not have any experience with plant medicine, or at least read the trials that have already been done, please sit this one out. You are making us look bad. The EO is opening a path to the millions of Americans that have failed conventional treatments. No one is getting addicted to ibogaine. Stop the fear mongering and be curious for once.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Two weeks without mobile internet improved mental health more than antidepressants and reversed roughly 10 years of attentional decline. Screen time dropped 49% (314 to 161 min/day).
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Paul Brown
Paul Brown@0xQuasark·
It's finally happening, the dam is bursting open. Psychedelics are going mainstream 🎉✌️
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Collin Rugg
Collin Rugg@CollinRugg·
JUST IN: President Trump signs order allowing psychedelic drug research to treat mental health disorders in the Oval Office with Joe Rogan. Joined with them was Americans for Ibogaine CEO Bryan Hubbard. Ibogaine is a “plant-based psychoactive compound” that has been used to treat people with drug addictions, traumatic brain injuries, and other issues according to Stanford Medicine. Hubbard has previously discussed the treatment on podcasts including the Joe Rogan Experience.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
You can now get your blood work at cost. We launched a biomarkers testing platform. I make $0 on it. Blood testing needs to be more accessible. Instead, we wait until we get sick. And in the meantime, companies profit when you’re sick. It's messed up. > get tested > find what needs attention > implement protocols > test again Get ahead of unwelcome surprises.
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