The Martin Ott lab

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: biorxiv.org/content/10.110… #mitochondria #mtDNA

We have an open Postdoc position! Join our lab in Gothenburg at the beautiful west coast of Sweden to work on an exciting project: nature.com/naturecareers/…

#MyXAnniversary We joined twitter exactly 6 years ago, now it is time to move on. Find us in the future on bluesky: @mitolab.bsky.social bsky.app/profile/mitola… Thanks everybody for the past years by making science twitter a great forum!

What are respiratory supercomplexes (SCs) doing? Our collaboration with @Holab_DukeNUS shows that an extra large SC forms between complex I and complex III in a mouse model of complex III deficiency. SC-XL rescues the respiratory defect. sciencedirect.com/science/articl…

I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others. rdcu.be/d5ACF #mitochondria #HHMINews

@carlstrm6 and I wrote a spotlight in @Cell_Metabolism on a recent paper from @puigserver_lab on respiratory supercomplexes in BAT that show substantially increased electron transfer efficiency. Here is a free link to the spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

@MuenchLab @goetheuni @IBC2_GU @EMBO_YIP @ERC_Research Fantastic, congratulations!!

Today marks 8 years @goetheuni-an incredible journey from group leader @IBC2_GU to now 🥳full professor & Director of the Institute of Molecular Systems Medicine in Frankfurt. Grateful for the invaluable support and amazing people along the way! @EMBO_YIP, @ERC_Research

This will be so exciting!! Thanks to @KAWstiftelsen for the support!

Mark your calendars for this year's Walter Neupert Lecture🎊

Fantastic!

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in @Nature rdcu.be/dRAQY collab with @DeuerlingLab Shu-ou Shan @Caltech @snsf_ch @ERC_Research @ETH_en

🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

Awesome fun activity at the retreat with the @Ott_MitoLab at Tjärnö Marine Station 🔬🪸🪼🦀🦭

Just back from a wonderful retreat with the @osman_lab in Tjärnö on the Swedish west coast @GothenburgMBL. Three days of scientific discussions around mitochondrial gene expression and maintenance, beautiful scenery and lots of fun. Thanks to everybody for the good times!!

@LabScorrano @ERC_Research @DiBio_UniPD @VIMMPadua @mitoPhD_Keisuke Congratulations Luca!! Exciting!

🎉🍾Thrilled that our project INTEGRATE has been selected for #ERCAdG by @ERC_Research!! @DiBio_UniPD @VIMMPadua we’ll now decipher intramitochondrial seeding and sorting of unfolded protein aggregates. Thanks to all lab members, especially @mitoPhD_Keisuke who spearheaded it! 1/

New paper from the Vögtle lab on how Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast: Developmental Cell cell.com/developmental-…

Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with @BukauLab @hauryliuk and many others! rdcu.be/dyFTI

Congratulations Dr. Andreas Carlström, PhD thesis✅ Thanks for being such a force in the group! And thanks for a great discussion by the opponent Chris Meisinger, Freiburg University, and the committee, Gunnar von Hejine @Stockholm_Uni, @krijonas and Joanna Rorbach @MolMet_KI !!