V☀️
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ॐ नमः शिवाय Date 13/3/2026 Big candel day All index/Any one Move 1.5% approx One sided in a single day जय श्री राम 🕉️🇮🇳🚩


@AbhiAttorney_ More crash coming ?

🧬 PAMI Syndrome (PSTPIP1-Associated Myeloid-related Proteinemiа Inflammatory syndrome) •Rare monogenic autoinflammatory disease •Caused by gain-of-function PSTPIP1 mutations (classically E250K, E257K) •Part of the PSTPIP1 disease spectrum (related to PAPA syndrome) ⚙️ Pathogenesis •Abnormal PSTPIP1–pyrin interaction •Inflammasome overactivation •Excess IL-1β signaling •Markedly elevated calprotectin (S100A8/A9) reflecting myeloid activation 🩺 Clinical Manifestations •Recurrent fever and systemic inflammation •Cytopenias •Neutropenia •Anemia •Thrombocytopenia •Hepatosplenomegaly •Skin: acne, pyoderma gangrenosum–like lesions •Joints: arthralgia ± arthritis •Recurrent infections (secondary to neutropenia) 🧪 Laboratory Features •Very high ESR / CRP •Extremely elevated calprotectin •Persistent cytopenias •Elevated ferritin (variable; may mimic MAS) 🔄 How it differs from PAPA syndrome •Less destructive arthritis •Much more systemic inflammation •Prominent hematologic involvement 💊 Treatment •IL-1 inhibitors (Anakinra, Canakinumab) → best evidence •Glucocorticoids → partial / transient response •TNF inhibitors → variable benefit •Supportive care for cytopenias & infection risk #RheumattDoc #MedTwitter #RheumTwitter #Medicine #rheumatology @DrAkhilX @IhabFathiSulima @CelestinoGutirr @DurgaPrasannaM1











