Pediatric Cell Therapy

New Research: Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease: Chronic graft-versus-host disease (cGVHD) remains a frequent cause of… frontiersin.org/articles/10.33… #immunology

In a retrospective study from 🇫🇮 of allo-HCT recipients, 59% of all and 77% of R+ patients had CMV infection. CMV infection was associated with longer hospital readmission: median 27 vs 14 days - an overall increase in use of hospital resources #CMV #TxID onlinelibrary.wiley.com/doi/10.1111/ti…

Busulfan Plus Cyclophosphamide Versus Total Body Irradiation Plus Cyclophosphamide for Adults Acute B Lymphoblastic Leukemia: An Open-Label, Multicenter, Phase III Trial ascopubs.org/doi/figure/10.…

Early use of third-party virus-specific T-cells is safe and leads to high rates of viral control and excellent outcomes in HSCT. loom.ly/eW36rVY #immunobiologyandimmunotherapy

10.1111/petr.14390 Metronidazole for treatment of norovirus in pediatric transplant recipients zpr.io/DUHZFDnFiMVv

📖 Our multi-centre study: 2 drug vs 3 drug induction in pediatric acute myeloid leukemia nature.com/articles/s4140… ✅ No benefit in survival with addition of 3rd drug etoposide (ADE) to dauno and ARAC (3+7) ✅ Similar toxicities ✅ First INPHOG RCT ✅ First RCT on AML from LMIC

KEY POINTS: ▪️ CCR9 is highly expressed in patients with T-ALL, including R/R T-ALL. ▪️ Anti-CCR9 CAR T cells show potent in vitro & in vivo antileukemic activity and resistance to fratricide, suggesting they could be an effective treatment. #ALLsm 👉 loom.ly/5vhEnPc 👈

@hmgcoa2 We had a patient who had unexplainable fever post hsct for months and finally she was diagnosed with lupus...

Non infectious causes of fever in a bmt patient.. inflammatory etiologies to think of 1. GvHD 2. Graft rejection 3.TA-TMA 4. Engraftment syndrome 4. MAS.. am I missing anything?

Have you read this? 🩺 Is calcineurin inhibitor-free #GvHD prophylaxis superior to Tac + MTX with BM in patients undergoing HLA-matched myeloablative HSCT? 👉 loom.ly/dIM074Q 👈

Immunogenicity of COVID-19 vaccines in patients with hematologic malignancies: a systematic review and meta-analysis loom.ly/-FOQxVY #systematicreview #clinicaltrialsandobservations #healthservicesandoutcomes

@nihardesai7 @MedTweetorials @Torsadepointles @pankti4299 @raghadesai We face several cases post hsct specially in patients with fanconi anemia and thalassemia who recieve calcineurin inhibitors as gvhd prophylaxis... Anybody knows how we could prevent it?!...

Hey #medicine residents !! 36, male, c/o B-ALL p/w headache and 1 episode of GTCS on D12 of therapy 😲 What is going on ? #MedTwitter

Acute GvHD therapy by Prof.@AttilioOlivieri #ITC22 @TheEBMT @TheEBMT_Trainee

Dr.@abazarbachi's excellent presentation on early endothelial complications after HCT📍TA-TMA 👏🏻 @TheEBMT @TheEBMT_Trainee

Our paper on #COVID19 in #Pediatric #BMTsm recipients is now in @ASTCT_Journal: Pandemic is still around & while outcomes in childhood HCT survivors are better than adults, there are still avenues for improvement & protecting those who are most vulnerable authors.elsevier.com/c/1fcTh9UKg~Zu…

📣 Check out this publication in @NLM_NIH📣 📃 Stem Cell Transplantation in Patients Affected by Shwachman-Diamond Syndrome: Expert Consensus and Recommendations From the EBMT Severe Aplastic Anaemia Working Party ⬇️ pubmed.ncbi.nlm.nih.gov/35870777/ #HSCT #BMTsm #MedTwitter

Manuscript from 🇯🇵: Letermovir associated w/ ⬇️ risk of CMV overall in HCT. In MV analysis, only significant factor associated w/ clinically significant CMV among those on letermovir was HCT from a CMV sero-Neg donor to a sero-Pos recipient #TxID #CMV onlinelibrary.wiley.com/doi/10.1111/ti…

Anemia overview (Handout from Run The List podcast @runthelistpod) #BJHM #MedEd #FOAMed #anemia #MedTwitter #hemetwitter #Medstudenttwitter

Blinatumomab offers clinically meaningful outcomes when added to prephase and consolidation in newly diagnosed patients with ALL. Find out more, and view our visual abstract here 👇 #leusm #allsm loom.ly/fYUikr4

A multiethnic study of #pediatric patients with #AcuteLymphoblasticLeukemia found multiple factors were linked to relapse risk, including #MRD status, with 136 MRD-negative patients relapsing compared to 73 MRD-positive patients.