

Peptide Decoded
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@Peptidedecoded1
Learn the science behind peptide








3 years ago, the obesity drug market was basically Ozempic. Today, it's 9 drugs deep in late-stage. Here's what each one actually adds: 1. Foundayo: latest oral GLP-1. @US_FDA approved April 1, 2026. Injections become optional. 2. Retatrutide: 24% weight loss at 48 weeks (Phase 2). Triple agonist. 3. CagriSema: less nausea than semaglutide. NDA filed December 2025. 4. Survodutide: GLP-1 + glucagon. Cuts liver fat alongside weight. 5. Amycretin: oral weekly. GLP-1 + amylin. Phase 2. 6. Petrelintide: amylin only. Phase 2 posted March 2026. 7. Mazdutide: China approved 2026. US Phase 3 ongoing. 8. Pemvidutide: obesity + MASH dual indication. 9. Monlunabant: CB1 inverse agonist. Phase 2. The next pharma cycle may not be Novo vs Lilly. It's shaping up as mechanism vs mechanism.
















Having a high appetite while being on a high dose of Retatrutide is one of the most underlooked and amazing phenomena’s in the peptide industry. Most people think appetite suppression is the entire goal, but retatrutide’s glucagon activity will increase energy expenditure and nutrient utilization beyond just “eating less.” In many cases, people are able to eat more, train harder, recover better, maintain muscle fullness, and still lose fat at a high rate. That’s a very different, and better, environment than traditional crash dieting where metabolism, performance, and energy all tank just to get lean.



Retatrutide VS Tirzepatide at a glance… Those side effect numbers for retatrutide are no joke… Went a little deeper in the article below… $LLY



These numbers are shocking. It's like we got a new frontier AI model but for the body. Lilly's phase 3 results for retatrutide: > highest dose lost 28.3% of body weight in 80 wks > 70 lbs ave > 45% lost 30% or more of their body weight > 65% on the top dose no longer clinically obese Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively. Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.







