Peptide Decoded

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Peptide Decoded

@Peptidedecoded1

Learn the science behind peptide

san diego Katılım Ocak 2011
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
Ozempic: 1 receptor. 15% weight loss. Mounjaro: 2 receptors. 22% weight loss. Retatrutide: 3 receptors. 24.2% weight loss. The third receptor makes your body burn more calories at rest. Nobody else has it. Full breakdown 👇 youtu.be/BTRkOxyrciU?si…
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
Two thirds of participants in the Retatrutide trial had a BMI below 30 at 80 weeks. Below 30 is the clinical definition of not obese. Two thirds of a drug trial. No longer obese. That has never happened before. youtube.com/shorts/c_W-15b…
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
5 findings from TRIUMPH-1. 30.3% weight loss. 45% hit bariatric surgery levels. 24cm waist reduction. 86% liver fat reduction. 65% no longer obese by definition. One drug trial. May 21, 2026. Full breakdown 👇 youtube.com/shorts/c_W-15b…
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Avi Roy
Avi Roy@agingroy·
Retatrutide. 28.3% weight loss. 70 pounds average. TRIUMPH-1 Phase 3, published yesterday. Every headline says “triple agonist.” Almost none explain why the third receptor changes everything. Ozempic and Mounjaro suppress appetite. That’s the GLP-1 and GIP part. Retatrutide adds a glucagon receptor. Glucagon doesn’t kill your hunger. It raises your resting energy expenditure. Your body burns more calories doing nothing. Two fronts: eating less AND burning more. That’s why retatrutide posted 28.3% vs Mounjaro’s 22% vs Ozempic’s 15%. The gap is in the mechanism. Phase 2 showed 24%. Phase 3 beat it. The high-BMI group lost 85 pounds over two years. Nearly half of all participants lost more than 30% of their body weight. I ranked 9 drugs chasing Ozempic’s market a month ago. Retatrutide was #2. The full pipeline, with every mechanism and timeline, is below.
Avi Roy@agingroy

3 years ago, the obesity drug market was basically Ozempic. Today, it's 9 drugs deep in late-stage. Here's what each one actually adds: 1. Foundayo: latest oral GLP-1. @US_FDA approved April 1, 2026. Injections become optional. 2. Retatrutide: 24% weight loss at 48 weeks (Phase 2). Triple agonist. 3. CagriSema: less nausea than semaglutide. NDA filed December 2025. 4. Survodutide: GLP-1 + glucagon. Cuts liver fat alongside weight. 5. Amycretin: oral weekly. GLP-1 + amylin. Phase 2. 6. Petrelintide: amylin only. Phase 2 posted March 2026. 7. Mazdutide: China approved 2026. US Phase 3 ongoing. 8. Pemvidutide: obesity + MASH dual indication. 9. Monlunabant: CB1 inverse agonist. Phase 2. The next pharma cycle may not be Novo vs Lilly. It's shaping up as mechanism vs mechanism.

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Real Peptides
Real Peptides@realpeptides·
Everyone is talking about Eli Lilly's retatrutide results in the pivotal phase 3 obesity trial. This is the proper breakdown, in full: (1/13)
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Bryan Johnson
Bryan Johnson@bryan_johnson·
These numbers are shocking. It's like we got a new frontier AI model but for the body. Lilly's phase 3 results for retatrutide: > highest dose lost 28.3% of body weight in 80 wks > 70 lbs ave > 45% lost 30% or more of their body weight > 65% on the top dose no longer clinically obese Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively. Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.
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CryptoDaddi
CryptoDaddi@TheCryptoDaddi·
Titrated up to 4mg of Reta today. Reading an overwhelming amount of positive reviews that say 4mg is the sweet spot for fat burning and also keeps sides away. Taking it every 6 days instead of once a week. Feels like I’ve about got this Retatrutide protocol dialed in. Anyone else running the same or similar?
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On The Pen™
On The Pen™@ManOnThePen·
The “starter dose” 4mg of Retatrutide having fewer trial dropouts vs placebo is not the flex people think it is. Retatrutide is maybe the most hyped pre-launch drug in history. It’s no surprise that unfortunate placebo recipients chose to peace out. Many of those who didn’t, likely thought they were on Reta based on placebo side effect reporting. $LLY
On The Pen™@ManOnThePen

Retatrutide VS Tirzepatide at a glance… Those side effect numbers for retatrutide are no joke… Went a little deeper in the article below… $LLY

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Max Marchione
Max Marchione@maxmarchione·
Retatrutide phase 3 obesity trial just came out and the results are genuinely insane: - 28.3% bodyweight lost on 12mg over 80 weeks - 70.3 pounds on avg. or 31.9 kg - 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory) - 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients - 65.3% of 12mg patients dropped below the obesity BMI threshold - 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%) - significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP - no cardiac or liver signals Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.
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Robert ₿reedlove
Robert ₿reedlove@Breedlove22·
These 2 brothers who've managed 50,000+ patient labs just revealed the biggest mistakes people make with testosterone, supplements & peptides. After I finished interviewing them, here are the top 10: 1. ''Peptides alone can fix your health''
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
Full 20-minute breakdown on the channel — every number, every diagram, every honest question. TRIUMPH-2 diabetes data and TRIUMPH-3 cardiac data still coming this year. We'll cover every readout as it lands. youtu.be/ysDaAPm9wew Drop a comment: does Retatrutide replace Mounjaro?
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
TRIUMPH-1 is the most significant Phase 3 weight loss drug data ever published. The Phase 2 data held. And it was surpassed. FDA submission expected late 2026. Approval 2027. If approved — the most effective weight loss drug ever approved. Full stop.
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Peptide Decoded
Peptide Decoded@Peptidedecoded1·
Eli Lilly just released the TRIUMPH-1 Phase 3 results. 30.3% average weight loss at 104 weeks. 85 pounds. That number has never been achieved by a pharmaceutical drug before. Here's the complete breakdown 🧵
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