Carmen Gu Liu, PhD

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, @kazu_maeshima, for supervision. Amazing collab with @rcollepardo’s group!" (1/n)

I received many inquiries regarding the Synogram, specifically on how to perform one. Below is a protocol that I wrote. Enjoy and blessings to your experiments! protocols.io/view/synogram-… #Synogram #phageantibioticsynergy #phageantibiotic #synergy

Just out! COBRA COBRA improves the completeness and contiguity of viral genomes assembled from metagenomes nature.com/articles/s4156…

I SAID YES!!! ❤️ ❤️ ❤️ 😭 😭 🥺LinkedIn asked me if I’m still a postdoc 😢

Never name a manuscript draft "_FINAL"

Bacteria can be pirates too... 🏴‍☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.110… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6

"Importantly, we also demonstrate phage-mediated L-form switching of the urinary tract pathogen Enterococcus faecalis in human urine, which underscores that this escape route may be widespread and has important implications for phage-and endolysin-based therapeutic interventions"

"Here we show that in osmotically stabilized environments, Listeria monocytogenes can evade phage predation by transient conversion to a cell wall-deficient L-form state"

Came across a really cool paper about phages and L-form bacteria: "L-form conversion in Gram-positive bacteria enables escape from phage infection" Source: nature.com/articles/s4156… #phage #evasion #phageinfection #bacteriphage

@MotherOfPhage xDDD

My phages as I add them to my culture

In this bioRxiv preprint, we (@_KevinCorbett ) present the architecture and activation mechanism of the PARIS antiviral defense system. Thanks to our co-authors, @Lisa_Liang13, @EnustunEray, and @PoglianoJoe, for their support in shedding light on this Anti-anti-defense system.🧵

I'm in my 4th year of #PhD, worked in different labs around the world, heard from several postdocs, PhDs and UG's... Dear supervisors, here are my suggestions to make your research lab a better place & attract talent! @PhDVoice @PhD_Genie @AcademicChatter @AcademicDilemma

Complete this sentence: Having a PhD doesn't necessarily mean that you are smart. But it does mean that you are ______________

Live footage of me writing this paper twitter.com/buitengebieden…

Alternative therapeutic strategies to treat antibiotic-resistant pathogens go.nature.com/46UFwOz In this Review, MacNair, Rutherford & Tan explore the potential of non-conventional therapeutic strategies in the fight against antibiotic resistance.

In people with cystic fibrosis, P. aeruginosa isolates from the same sputum sample have diverse antibiotic resistance profiles, which may explain the discrepancy between in vitro & in vivo antibiotic efficacy when treating infections. @JournalSpectrum: asm.social/1Ba

Phd

Sheffield #BioFest, was fab! Great to talk with so many folk about phages and hear their insights.Thanks to the Sheffield microbiologists for the company and delicious curry after. Snaps are of Luke Jerram's giant E coli and glass T4, so beautiful, do go and see them if you can!

!! Release update !! If you uses iPHoP for phage host prediction: we just released a new version (1.3.3), alongside an updated host database now based on GTDB r214. Updated code and database available via conda / Docker. Please report any issues to bitbucket.org/srouxjgi/iphop…

Machine learning for microbiologists nature.com/articles/s4157… In this Review, Segata, Waldron and co discuss key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools to apply machine learning in microbiology research.