Philip Ruthig

We are hiring a Lab Technician/Scientist at @DeepPiction At Deep Piction, we work on medically unmet challenges using high-resolution whole-body imaging with AI. To make this possible, we need strong wet-lab execution. 🔗 APPLY HERE: linkedin.com/jobs/view/4396… This role will support the team across diverse experimental workflows and help ensure that our work is reliable, reproducible, and scalable. If you enjoy hands-on lab work, structure, and making things run properly, this could be a great fit. 📍 Munich, on-site At Deep Piction, we work on medically unmet challenges, including infectious diseases and cancer. We combine high-resolution whole-body imaging with AI to develop the most targeted and precise therapies. To make this possible, we need strong wet-lab execution. This role will support the team across diverse experimental workflows and help ensure that our work is reliable, reproducible, and scalable. If you enjoy hands-on lab work, structure, and making things run properly, this could be a great fit. 📍 Munich, on-site If someone comes to mind who would be a great fit, I’m sure they would be excited to see this opportunity, please feel free to share. If someone comes to mind who would be a great fit, I’m sure they would be excited to see this opportunity, please feel free to share.

Proud to share that @DeepPiction has been awarded a €2.5M EIC grant, one of Europe’s most competitive funding programs for startups (success rates as low as ~3%). With this, we’ve raised €7M in the last 8 months across grants and seed financing. We’ll use this to push our precision drug development platform forward to tackle major medically unmet needs, starting with Long COVID. Excited for what’s next, and always happy to connect with potential co-development partners, collaborators, and future team members. eic.ec.europa.eu/news/61-start-…

From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, bit.ly/vdisco). We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, nature.com/articles/s4159… Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026). cell.com/cell/fulltext/…

Most transcriptomics studies sample ~0.001% of a mouse. Which region to choose? Often we guess. We introduce DISCO-seq🤗flipping the order: Whole-body 3D imaging with RNA-preserving clearing→ pick ROIs in 3D→ unbiased scRNAseq Led by @HarsharanBhatia biorxiv.org/content/10.648…

🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form lnkd.in/gCgdaJuV Please also send your application to: farida.hellal@med.uni-muenchen.de CC: ali.ertuerk@med.uni-muenchen.de 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

We merge the programmability of DNA nanotechnology with the versatility of lipid systems. Introducing LipiGo, engineered to detarget the liver upon systemic administration and enable precise active targeting 🎯

We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi biorxiv.org/content/10.110… 1/n

That leaves me to thank my excellent co-1st author David Edler von der Planitz, and our collaborators and co-supervisors @siawooshmn, Nik Weiskopf, @EvgeniyaKirili3, and Markus Morawski! A collaborative project of @MPI_CBS and @UniLeipzig!

That concludes the thread - find the full paper here: plos.io/4mq5tOy

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are? In our recent paper we find that indeed, they are! Read the thread below ⬇️⬇️⬇️ plos.io/4mq5tOy #neuroscience #whitematter #AI

AFZAL MUHAMMAD So heißt der Held aus #Mannheim, der den Attentäter stellte. Muhammad ist Taxi-Fahrer & Muslim. Das rassistische Weltbild einiger wurde heute in kleine Teile zerlegt. Weidel schweigt, Sellner kommt nicht mehr klar. Die Nationalität des Täters sollte klar sein.

„Als klar wurde, dass wir in Deutschland große Datenmengen transportieren müssen, gab es 3 Verkehrsminister (Rammsauer, Dobrindt, Scheuer) und die haben den Deutschen eingeredet, wir müssen die Kupferkabel optimieren. Und es sind die gleichen Vögel, die uns jetzt sagen, wir müssen die Ölheizung optimieren.“ @roberthabeck

See our recent @NatureBiotech study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s4158…