Karoline

We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi biorxiv.org/content/10.110… 1/n

Exciting🥳 Our new study in Cell shows that our skull is a gateway for diagnosing & potentially treating brain diseases such as Alzheimer's & stroke. Imagine a future where a portable sensor on the skull can monitor brain health! @CellCellPress cell.com/cell/fulltext/… 🧵👇🏼with🔈

We are thrilled to present our new study unlocking precision in nanoparticles. Cell-level resolution imaging is key in targeted nanoparticle development. See our work on DNA Origami🧬: biorxiv.org/content/10.110… by @MolbayM, @shan_heather, Benni Kick et al, with @hendrik_dietz.🧵👇🏼

Want to use deep learning for image analysis but lack the coding skills? We introduce DELiVR, a game-changer in brain-wide cell analysis. No coding required, our Fiji Plug-in does the magic. Hats off to @Dorie00, @Rami96614090, @moritz_negwer! 🧵👇🏼 1/n biorxiv.org/content/10.110…

Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM @jieluo692 biorxiv.org/content/10.110… 🧵👇🏼(turn on the sound)

Spatial-omics goes 3D🤗! Out at Cell @CellCellPress 👉🏼 We developed DISCO-MS with @labs_mann, a spatial proteomics technology for specimens fully imaged in 3D. DISCO-MS is aided by robotics and enables the study of diseases at their early stages. cell.com/cell/fulltext/…🧵👇

The skull is considered a physical barrier (helmet) for the brain. Our new findings show that the skull can be utilized to interact and monitor neuroinflammation in diverse brain diseases. #scRNAseq #proteomics #skull #AI #clearing #TSPOPET biorxiv.org/content/10.110… details🧵👇1/n