Philip vN

I have now watched this entire video. It is way more important than I thought it would be. @gravicle lays out a Unified Model and makes a compelling case for why this is the future of AI.

I sequenced my genome at home, on my kitchen table. I wrote up exactly how I did it - the equipment, protocol, theory, and cost: iwantosequencemygenomeathome.com

This is AWESOME... Some guy just sequenced his entire DNA genome on his kitchen table 🧬🧪 It tells his cancer risk, drug responses, what his kids will inherit, and which diseases are coming decades before the symptoms. Your genome is a 3.2 billion letter source code that predicts more about your health than any other test in existence. Almost no one has ever read their own. This used to require a hospital, a specialist, and a referral that most doctors won't write. The raw data would sit in a medical record you'd never see. Until now. Here's how he did it: → Rubbed a cheek swab against the inside of his mouth for 60 seconds → Extracted the DNA from his cells using a $150 kit → Prepped the DNA for sequencing with enzymes that attach a motor protein to each strand → Loaded the sample onto a nanopore device the size of a highlighter, plugged into a MacBook The device works by pulling single strands of DNA through holes one atom wide. As each letter passes through, it changes the electrical resistance in a tiny but measurable way. A neural network listens to the signal and reconstructs the sequence. 48 hours later, he had his full genome on his hard drive. The data never touched a server. No spit kit in the mail. No company owning his most sensitive biological information. No risk of the whole thing getting auctioned off in a bankruptcy, which is exactly what happened to 23andMe's 15 million customers earlier this year. AI is unlocking personal health in a way that has been impossible. We're still so early.

someone just open-sourced a full 3D building editor that runs entirely in your browser. 💀 no AutoCAD. no Revit. no $5,000 annual license. no install. just open the tab. the AEC software industry has been selling the same tools for 30 years and charging more for them every year. the moat was never the technology. it was the switching cost and the file formats. a browser-based open-source alternative doesn't just undercut the price. it removes the reason to ever open your wallet in the first place. architects, urban planners, indie game devs, anyone building physical things who got priced out. this is for them. Autodesk has had a good run.

That image looks almost exactly like a slice of your brain under a microscope. An astrophysicist and a neurosurgeon spent years figuring out why. The numbers line up way too well to be a coincidence. Their 2020 paper took an unusual approach. They put pictures of brain tissue next to pictures of the universe and measured everything they could: the shape, the connections, how densely things clumped together. Almost every number came back the same. In the image above, each bright dot is a galaxy, and each dim strand is a filament pulling galaxies toward one another. Each galaxy sits inside a network, connected to about 4 others on average. Zoom into brain tissue with a microscope, and each neuron connects to about 5 others. The clustering pattern matches, and the overall shape of the network does too. One system fits inside your head. The other stretches across tens of billions of light-years, a size gap of roughly a billion billion billion. And the parallels go deeper than structure. Your brain is 77% water, sitting there and taking up space. The universe is 70% dark energy, also sitting there and taking up space. In both, only about a quarter of the total stuff is doing any real work. Your whole life's worth of memories would take about 2.5 million gigabytes to store. The full complexity of the observable universe, every galaxy position across 90 billion light-years, would take roughly 4.3 million gigabytes. Not far apart. The picture in this tweet is the new DESI map, a project from a telescope in Arizona that just finished cataloging 47 million galaxies over five years. That is six times every previous galaxy survey put together. And when you look at it, you are looking at something built like a brain. Either the universe runs on the same playbook your head does, or there are only a handful of ways any complex network can organize itself.

China is beating us at solarpunk. It's so over.

THIS GUY JUST DROPPED A 16 MIN TUTORIAL ON USING GEMINI 3.1 + SEEDANCE 2.0 TO BUILD CINEMATIC $10K WEBSITES

This AI is pretty wild. LingBot-Map can turn a live video stream into a 3D reconstruction in real time. 20 FPS Code + Model 👇

@zostaff When will it convert to a volumetric video (3DGS) that One can explore navigate in immersive VR?

AI FOOTBALL ANALYSIS. A FULL COMPUTER VISION SYSTEM. BUILT ON YOLO, OPENCV, AND PYTHON. You upload a regular match video. No sensors, no GPS trackers, just camera footage. The neural network finds every player, referee, and ball on its own. Every frame, in real time. KMeans clustering breaks down jersey colors pixel by pixel. The system splits players into teams automatically. Without a single manual hint. Optical Flow tracks camera movement. Separates it from player movement. Perspective Transformation converts pixels into real meters. Speed of every player. Distance covered. Ball possession percentage. All calculated automatically. Four hours of tutorial from zero to a working system. The model is trained on real Bundesliga matches. Runs on a regular GPU. Python code - take it and run. Sports analytics is no longer behind closed doors. AI leveled the playing field.

Most digital twin investments stall for one reason: They’re not grounded in how the world actually looks today. Niantic Spatial’s Reconstruction capability fixes this, creating a living, machine-readable 3D model that stays in sync with reality, so every system, team, and workflow operates from the same ground truth. In a new blog by Trista Pierce, Business Development Lead, explore how Scaniverse’s Reconstruction technology changes the cadence entirely. Read more: hubs.ly/Q04brNtg0

Imagine you’ve bought a brand new Lamborghini, only to find that you’ve been driving in 1st & 2nd gear with the parking brake on the entire time. That’s where most #AI interactions are today. But we can fix this. open.substack.com/pub/wgburns/p/…

@NASA passengers on board an Atlanta to Puerto Rico flight saw Artemis II flying right there in the sky… like human beings just got front-row seat to space history 🚀

@elonmusk A very cunning Lingus move. 😉

Some might call this a cunning move 😉

After traveling 9 years and covering 3 billion miles, NASA's New Horizons spacecraft got this shot. Behold! The icy mountains of Pluto.

@auradeluxe Coordinate a commensurate counterstrike on the leaders of the attack against him?

Amazing. Totally coordinated attack on Newsom. What we doing, people?

Long ago I visited MIT Media lab and the brain researchers there said they had no idea how to even map out a brain. Well, they are figuring it out.

Chatbots aren’t the revolution. They’re the distraction. Fei-Fei Li: “Language is a half-million-year-old luxury. Perception is a half-billion-year-old necessity.” Evolution didn’t optimize for conversation. It optimized for survival in three-dimensional space. Seeing threats, navigating obstacles, predicting what happens when you move. We’ve spent years celebrating AI that can write and summarize. But text processing is narrow. Spatial intelligence is fundamental. An agent that only reads prompts can’t function in a warehouse or a hospital. It needs to parse depth, understand physics, and act on what it sees in real time. We built AI that understands language. Now we’re building AI that understands space. Language models got the attention. Spatial intelligence gets the work done. The world runs on physics, not paragraphs. AI is learning to operate in it.

China just released a desktop automation agent that runs 100% locally. It can run any desktop app, open files, browse websites, and automate tasks without needing an internet connection. 100% Open-Source.

China just released a desktop AI agent that runs 100% locally. No API. No cloud. No tokens. Free. China is not playing around. Do you realize what's happening? China's investment in open-source AI is slowly rendering US frontier companies irrelevant. OpenAI, Anthropic, Google, their entire profit model relies on API tokens. They raised billions based on projections of you paying per word. What happens when the model is free? The moat isn't the model anymore. It's the ecosystem, the trust, the integration. And China just showed they're willing to give away the model for free to win the ecosystem. Interesting times.