Ruslan Dmitriev 

#Preprint alert! Together with Filatov's group (TUD), we report a new type of O-BODIPY dyes displaying exceptional brightness & fluorescence lifetime range sensitive to... water! chemrxiv.org/doi/full/10.26… works great in #FLIM with cells, spheroids & organoids! @microscopyUGent

@wariocolosseum 100%

gen ai could disappear overnight and not only would it not do damage but it would actually be a massive positive for the entire world

@Tabdanov "good science deserves to be seen" - so why creating a tunnel vision and limiting ourselves to 1%.

It’s the shit like this that ruins science. Stop masturbating on AI and pointless scientific metrics. All of it will age badly.

@xriskology Like your comment 'AC will fix this', that's exactly what I hate hearing currently

AC AC AC AC AC will fix this! Dumb Europeans!

with scarcity of funding and being involved in other projects, for me it is the longest 'research paper' story ever. Over the years Alex accumulated more evidence clarifying the mechanism #Raman #CytC #Hypoxia #cancer #complexIV. Enjoy the reading [2/2]: biorxiv.org/content/10.648…

#PreprintAlert Happy & relieved to see this preprint out: together with Alex Zhdanov & Dmitri Papkovsky from UCC, we have discovered more than a decade ago that Cytochrome C accumulation in hypoxic cancer cells is not always associated with activation of apoptosis [1/2]

@blekhman thanks for analysis, question (perhaps stupid) about consent: if I upload with CC-BY-NC-ND licence, does it not protect your preprint from being 'used'?

I wanted to like QED's new 1% preprint ranking. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review: open.substack.com/pub/blekhman/p…

@MattNoahSmith well, Google maps often doesn't know and provides inaccurate information or simply outdated. Having a normal printed map and memorising it can be and often sufficient in a new city.

I teach college and here's the thing: Writing is a materialized form of thinking. It is not just a way to record thoughts. It is a concrete route to understanding. If one uses a machine to write, they cease thinking. They abandon a route to understanding. Not good!

@ihtesham2005 ofc it is hard to deny that everyone uses AI s**t because it's being pushed everywhere - OS, smartphones, search engines...whatever but it doesn't help, it just helps, follows the #enshittification trend

@ihtesham2005 totally agree with Jennifer, just so sad seeing so much of investment going to nowhere, considering the cost-benefit of all these datacentres and their effect on the environment, climate etc. +regular scientists have now lower capability to afford a good PC/GPU for own research

Jennifer Doudna won the Nobel Prize for gene editing and went on Bloomberg to say the chatbots everyone is betting on cannot innovate at all. Every promise Silicon Valley is making about AI curing disease just hit the one person qualified to check it. She has spent her whole career inside the actual frontier of curing disease. So when she talks about what AI can and cannot do in biology, she is not guessing. She is reporting from inside the lab. Her words were blunt. She is not seeing chatbots innovate. They summarize data. They write reports. They do not come up with a brand new idea nobody has ever had. Then the interviewer pushed. So you're saying AI can't innovate? Doudna did not flinch. She does not know if it can't. She just does not see it doing it right now. This lands harder when you remember who is making the opposite case. Sam Altman says AI will eliminate disease within five years. Larry Ellison says AI will cure cancer in a 48 hour window. An OpenAI executive even floated that the company should get a cut of sales on any drug discovered through ChatGPT. Doudna answered that in two words. Good luck. Even the cancer specialists Altman is selling to keep warning that cancer is not one disease but hundreds, each needing its own cure, and that compute does not skip the years of lab work. Her reason is simpler. Biology is hard. You cannot simulate your way to an understanding of the human body. The people promising cures are the ones selling the tool. The person who actually won a Nobel building them is telling you it has not happened yet. Source: Bloomberg Originals Watch the full video on their official channel.

@AftynOSRS @EllisWyatt1971 @WxNB_ I bet Paris was not such a lively and populated city 10,000 years ago

@EllisWyatt1971 @WxNB_ Going back that far only gives estimates of averages. Europe was likely warmer 10,000 years ago during the early Holocene due to natural orbital cycles, but the data shows an *additional* rise in relative high temp frequency on top of that natural variability.

Paris, the capital of France, has recorded more days above 40°C this week than during the 147-year period spanning from 1872 to 2019. Historic is an understatement.

@MrMatthewTodd well said, I agree with you. I am amazed that no-one takes a responsibility (politicians, governments, billionaires etc.), like some sort of aliens have invaded the planet and took the control (and they require hotter planet)

They were talking on the news about how we’re going to have to adapt for a radically hotter country. They said it like it’s normal, like we are meant to just accept that all our lives have been degraded forever just so that the fossil fuel industry can earn more billions. There really should’ve been a revolution by now.

@RogerR46384 @MrMatthewTodd exactly, cars, planes and data centres, poor urban planning. I think it's only 1/5th person on a planet who uses/ has a car so decreasing this only two times would deliver a tremendous benefit but yeah, there's less comfort in that...

@MrMatthewTodd People refuse to walk 12 blocks or ride a bike 3 miles is why we have global warming. Voters FIGHT against protected bike lanes/transit funding. Car Brains is why the fossil fuel industry is so huge. Car brains kill 1000s every year.

@xriskology @oeill_l @elonmusk well said, thanks for this

@oeill_l @elonmusk Derp. realtimetechpocalypse.com/p/heres-why-sp…

Amazing that such a massive brain could have so little imagination; Humans have proven themselves to be nearly as adaptable as cockroaches. Silly goose. Mars is ours. @elonmusk

@OdedRechavi I would for sure, still excited to do organoids and microscopy but would definitely turn from too 'biomedically relevant projects' to something more exciting, e.g. imaging & studying fungi

If you were rich, but not super rich, would you fund your own lab? How would it change what you study? It's different from "what would you do with unlimited money” (which is also a difficult question, that poor MPI directors have to face), I am asking what would you do If you had just enough money to stop pretending and pleasing reviewers, but not enough to stop worrying - what science would you do? Feels like a ghost dog type of mental exercise.

Hydration-Gated Photoinduced Electron Transfer in O-BODIPY Dyes ( @ChemRxiv ): chemrxiv.org/doi/full/10.26… (@PhotoBioLab , Mikhail A. Filatov ).

we should be glad that journals like "Frontiers in..." exist so we can quickly see how the peer-review & publication process should not be organised

@rust_ruslan PhD students still need publications, funding agencies (or reviewers of your grants) as well. Otherwise I agree, seeing a great preprint often does not require to read a later published 'real paper'

Is it just me, or do others feel like there is basically zero reason to send a *Rxiv preprint out for formal publication anymore? What's actually the main driver for you to still do it?

I am sending an open letter to Thermo Fisher. Their response to my response to their manipulated western blot is bullying and petty. Yes, this western blot really is manipulated, it is unfair on me to say otherwise. I don't make those accusations lightly. #ThermoFishy

@OdedRechavi absolutely

Most experiments fail, and negative results rarely get published. This means LLMs are unaware of the outcomes of most experiments.