Inflammasome Assembly Inside Human Cells Captured for the First Time | Technology Networks technologynetworks.com/immunology/new…
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Phyllis Wang
70 posts
Phyllis Wang
@Phyllis23382012
Structural Biology 🔬 | Immunology ❤️ | Chamber musician 🎻 | Composer&Lyricist 🎼
Pasadena, CA Katılım Nisan 2021
154 Takip Edilen56 Takipçiler
Phyllis Wang retweetledi
Excited to share our paper on the NLRP3 inflammasome condensate at the MTOC by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang@Phyllis23382012in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! science.org/doi/10.1126/sc…
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Phyllis Wang retweetledi
Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy
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Phyllis Wang retweetledi
For the first time... 🦠
Scientists captured how a key part of the immune system forms inside intact human cells, & revealed a dense, gel-like structure that looks surprisingly different from the cartwheel shape expected:
stanford.io/4s1mu3B
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A big part of my graduate work has finally made it online. Proof that science loves to surprise us in experiments😎 @theJensenLab Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center | Science Advances science.org/doi/10.1126/sc…
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Demonstrating the workflow was a blast, feels definitely different from my day-to-day experiments😂
Jensen Lab@theJensenLab
Check out our @JoVEJournal video article with @Phyllis23382012 describing how to use a new tri-coincident fluorescence, electron, and ion beam microscope for targeted milling of cells! Full video & article: hubs.ly/Q047QRRK0 #JoVE #Reproducibility
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Always dreamed of putting together a solid protocol for guided milling on challenging specimens. Now available online!
Jensen Lab@theJensenLab
Producing lamellae containing small and rare fluorescent targets is getting more efficient: app.jove.com/t/68238/workfl…
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Phyllis Wang retweetledi
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH
Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
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Phyllis Wang retweetledi
Our lab provided tomography data for this exciting competition, which aims to accelerate the cryo-ET workflow. If you're skilled with AI and machine learning development, please participate!
BYU_BiophysicsGroup@BYU_Biophysics
Interested in helping solve a machine learning problem for structural biologists (and competing for a cash prize)? Check out our @kaggle competition that launched yesterday: kaggle.com/competitions/b… We look forward to seeing your submissions!
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Phyllis Wang retweetledi
What an exciting news and a huge honor! Our 2014 paper on ASC-PYD inflammasome filaments (Lu et al., Cell) has been recognized as a landmark in Cell’s "2014–2024 Timeline"! 🔥🔥🔥 #Inflammasome #PYD #StructuralBiology
🔗 cell.com/action/showPdf…
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Phyllis Wang retweetledi
Excited to share our preprint biorxiv.org/content/early/… showing convergence of GBA1 and LRRK2 mutations in PD: both block Hedgehog signaling and decrease neuroprotection for dopamine neurons @ScienceofPD @ASAP_Research
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Phyllis Wang retweetledi
I'm also very happy to announce that @ludovic_autin will be continuing the cell modeling work, so stay tuned for exciting developments on his profile. For example, take a look at the Mesoscale Explorer molstar.org/me/
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Phyllis Wang retweetledi
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s4146…
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Fish keratoctye cells crawling around while be videoed through my DIC microscope. Video length: 45 minutes. #CellBiology
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Phyllis Wang retweetledi
🚨 Attention PhD students! 🚨 We have a 12-week paid internship opportunity at Genentech. Want to see how we use cryo-ET in pharma and spend summer 2025 in the Bay Area? Details and application link here: roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
Questions? DM me.
Please RT & share!
#teamtomo
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Phyllis Wang retweetledi
Free scientific illustrations for biologists! 😍
@NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations!
all freely available in the public domain.
Retweet and spread the message!
bioart.niaid.nih.gov
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Phyllis Wang retweetledi
Bacteria can be pirates too... 🏴☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.110… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6
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Hey #teamtomo, here's a cryoEM Rorschach test. What is this? Anyone without inside information, post your guess in the comments!
We hope to post the answer on biorxiv within a week. :)
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@GatsogiannisLab @NatureComms @Sfb1348 @uni_muenster Beautiful work! Curious about why you chose those specific tilt angles (e.g. 21, 32, 42) to collect data? Is it stage related or there is a particular reason behind? Did you keep total dose at 50 for all data collection?
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"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 @NatureComms #Neuroscience #Toxin #cryoEM @Sfb1348 @uni_muenster
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@MAG2ART Curious about mitochondria distribution. Do they always cluster near the Golgi?
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A cell photographed through a microscope. Mitochondria (pink), Golgi apparatus (blue), and actin filaments (orange) are shown. #CellBiology
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