Dr Anna Borek

🚨If you're interested in the KETO-CTA study, you may also be interested in this short book 📖. It offers: 1⃣ a sustained critique of the fringe hypothesis that LDL-C lacks clinical relevance in a subset of ketogenic dieters; 2⃣a thorough analysis of the KETO-CTA study, and; 3⃣an exposé of the scientific malpractice committed by its authors. 💬I'm certain this is not the end of the story & I will update this book periodically with new chapters as the evidence evolves and the narrative unfolds.

RFK Jr. describing guidelines as putting "Fruit Loops at the top of the food pyramid." 🤦 * The food pyramid was scrapped in 2005. * Guidelines have never said to prioritise cereals high in added sugar. * Foods at the top of the pyramid were to be limited, not favoured. (cont.)

Another top nutrition scientist arguing in favour of plant based meat alternatives and against the UPF scare. independent.co.uk/life-style/ult…

The "ultra-processed food" mania has now reached the point where we celebrate spoilage. Presumably those people don't really care about food waste, because they can afford it. And there is still brioche for all the others ...

The problem with this book is: it contains dangerous nonsense that puts women at risk because the author lacks scientific understanding. Just claiming to be a feminist does not make up for not understanding physiology, biochemistry and food science.

@ApoDudz Can't be bothered to reply to all this. But I would say that all results should be considered hypothesis generating.. regardless if pre-specofied: because it is a small, unrandomised pilot study with numerous limitations.

Thanks Anna! 1. Bc that is the pre-specified endpoint (%ΔNCPV) that everyone has pulled out their pitchforks over deceptively excluding? 🤣 granted the pre-specified analysis is QAngio, not Cleerly or HeartFlow. I agree relative and absolute measures are relevant. All the data would be interesting to see. 2. It’s not just about the relative change value, it’s the large discordance bt the two analyses, which may or may not be surprising but difficult to interpret IMO. 3. 👍🏻 4. Agree but even then I suspect it’s difficult to draw strong conclusions. 5. Ascribing speculative intent is out of the realm of scientific critique - particularly when the reason given in the video was discordance with TPS, should take at face value IMO. Having that said, if Cleerly were more concordant with TPS, not sure if HeartFlow would have been conducted, glad there are more data than less - irrespective, both Cleerly and HeartFlow should be viewed as hypothesis-generating data given the pre-specified methodology is QAngio. Thoughts?

Finally got around to watching the update on the KETO-CTA cohort. Not much to say for now – I’ll take a closer look once their paper is published. Thoughts: 1⃣ Why are they focusing on relative measures, especially when several of the authors have agreed that this is misleading? 2⃣ From what I tell, the absolute change that picked up by Cleerly in those with a CAC score of 0 = minimal. So the reported >100% relative change feels quite misleading in that context. 3⃣ I tend to think Cleerly may be a more sensitive software package – that it picks up small absolute changes, which, of course, tend to translate into large relative changes. 4⃣ I'm not sure it makes sense to compare one AI tool to another – without an internal control, the best we can do, I imagine, is compare Cleerly data to other cohorts that also used Cleerly. Likewise, the same should be done for the HeartFlow and QAngio analyses. 5⃣ Would any of these re-analyses be happening if the Cleerly results had aligned with the ideological bias of the authors – and the study's funders? I don’t think it’s overly cynical to suspect not.

Changing Coke from high fructose corn syrup to cane sugar is just like rearranging the chairs on the titanic. Good work y’all 😂😂😂

Nice new paper from the Malmo Diet and Cancer Study finds higher intake of fiber and fruits and vegetables is associated with roughly half the risk of rheumatoid arthritis, while higher intake of red and processed meat is associated with a near doubling in risk.

There are certainly limitations in the data linking saturated fat to cardiovascular disease but here's the rub - it's the nutrition rec with the most consistent data (pretty much every line of evidence supports replacing satfat with mixed unsaturated fat sources). If you amplify the limitations in this data to the point you think a rec can't be made,then you can't recommend really any other diet-chronic disease advice while being intellectually honest and rigorous

Or you can run for 30 mins to burn 400 calories and... 1) Have more space for nutrient-rich foods 2) Not have to cut calories super low to lose weight 3) Be fit, have more stamina, and better health A good diet & exercise > one or the other.

There are two UPFs most people agree are bad for health: soft drinks and processed meat. Isn't it funny that one of the crusaders against UPF thinks processed meat is still fine (but sliced bread is dangerous)?

I think I've become convinced that veganism is, in fact, morally obligatory.

The history of bread is a great example why the UPF discussion is silly: originally, sourdough, hand kneading and whole meal flour were used. When did bread become UPF - with the use of isolated yeast? With white flour? The introduction of machines? The Z-blade? Where do we draw the line?

Starbucks - a purveyor of largely sugar-sweetened and creamy coffee beverages, baked goods, and sodium/refined grain-loaded sandwiches - has 'very clean foods' per the HHS secretary and he's asking him to get rid of canola oil.. History will look back on the misspent MAHA energy to impact chronic disease and see it as little more than industry friendly marketing with a dash of chemophobia

@QuaintTransfer Agreed.

@Pl4ntbased Taking a semaglutide shot once a week, or getting bariatric surgery

Why all the hate for calorie counting❓ 💬It’s simply an optional tool — one that clearly works well for many people.

@QuaintTransfer What can the vast majority of people pull off?

@Pl4ntbased But in practice the vast majority of people cannot pull this off.

@ApoDudz @DrEricRodgers @theproof @ethanjweiss @drpablocorral @NutritionMadeS3 @drgarymcgowan I've not been able to look at it yet. I certainly will and shall try to understand these results as reasonably and thoughtfully as possible.

@DrEricRodgers @Pl4ntbased @theproof @ethanjweiss @drpablocorral @NutritionMadeS3 @drgarymcgowan Honestly was just hoping to get Anna’s genuine take. Not looking to antagonize anyone 🙏🏻

I’ve been waiting to get @Pl4ntbased’s take on KETO-CTA HeartFlow analysis - apologies if I missed. Anna, have you any opinion on the discordance between the two AI analyses, according for semi-quant as well (if you think that is relevant)? This is completely genuine FWIW.

@followthemotive @dietiti3n True.. but even if they accept that CICO explains the favoruable changes in bodyweight... it is very common for zealots think that everyone will be able to hit their ideal weight by eating ad lib... which is highly dubious imo.

@Pl4ntbased @dietiti3n Yes, this is the primary answer. If the tribalists counted calories, thermic effect of food, and total daily energy expenditure faithfully, the caloric deficit or surplus would tell the bodyweight story more than the magic imbued in the dietary pattern would.

@ScottAppliedSci @maxlugavere @Cleerlyhealth I don't imagine that fake praise is valuable tbh. I agree that it's important to understand your interlocutor's point of view and to steel man it before commenting. But a token compliment.. well, it's not for me anyhow.

@Pl4ntbased @maxlugavere @Cleerlyhealth I also sounded a bit judgy there! I've done plenty of typical X ASPD over the years. :o)

10 years of a "perfect" plant-based diet and still plaque? Here's a shocker: I recently did @Cleerlyhealth too. I'm older than Simon (42 at time of scan) and an ApoE4 carrier (genetically prone to high LDL/ApoB). Simon has 5x more total plaque and 20x more high-risk soft plaque than I do. His plaque is in multiple vessels and he has detectable calcification whereas I have none. Please note that health is not a pissing match and I wish good health to all. I just practice what I preach in my books and on my podcast: data-driven nutrition and common sense, not ideology.

@ScottAppliedSci @maxlugavere @Cleerlyhealth Okay but that confirms my suspicion that you didn't mean it haha ignore me

@Pl4ntbased @maxlugavere @Cleerlyhealth I find in life that opening with criticism, then doing the body of the critique, and finally closing with a scathing remark .... isn't a good human-to-human communications strategy. Attack-attack-attack is fun but pretty limited.