Tim Gallagher

@MLB_Mudcats @MLBRaleigh Durham Bulls!

Who would you rather have as Raleigh’s MLB expansion team? @MLBRaleigh please retweet this for reach, as we want this to be as accurate of a poll as possible.

@daphnezohar @drrichjlaw @realDonaldTrump @US_FDA “Deep regulatory experience” and “track record of reform” together really narrows the field…..

An appeal to @realDonaldTrump from those of us developing potentially life changing medicines. The next @US_FDA commissioner should have: deep regulatory experience, a track record of reform, and the ability to lead a scientific institution under political & competitive pressure without compromising speed or rigor nopatientleftbehind.org/fda-recommenda… Rick Pazdur is one exemplary candidate and the industry looks forward to supporting whoever is appointed. Thanks to @NPLB_org & @PeterKolchinsky for initiating - please sign & share.

@RDUAirport Walk Duke Gardens and Dix Park for Sunflowers Shop the State Farmers Market BBQ at Sam Jones BBQ Visit the Howling Cow farm for ice cream. Look for eagles at Jordan Lake.

"Raleigh-Durham has no culture" Time to prove the people wrong, put your suggestion in the replies

@anish_koka Spot on.

My take is that Makary and prasad approved a wide array of therapeutics that actually worked that didn’t have an RCT and cowrote a number of articles in a little “paywalled journal” called the NEJM 🙄 outlining a framework for lowering the regulatory bar for promising therapies. Their exit from the FDA has more to do with the lord of the flies ecosystem of incompetent middle managers in charge at the FDA and in Congress that exploit rare disease patients to demand the nurturing of zombie companies with therapies that don’t work/could potentially be dangerous. Makary would have had to overturn an FDA on therapies that were potentially dangerous with incredibly weak signals of efficacy. The first decision that lead to Vinay’s firing was keeping a drug on the market that was killing kids (approved with similar dubious data) But I don’t think it would have mattered in the end. Makary and Prasad were outsiders who thought they had a mandate to disrupt a hierarchy and they elicited a fierce antibody response. What the politicians need when gas is $5/gallon and midterms approach are not headlines about FDA in chaos that are sourced from the status quo partisan zipcode the FDA resides in. That requires someone who FDA middle management approves of which is basically someone more well versed in politics than science. More broadly, we should allow for expanded access to whatever people want to try— whether the FDA approves it or not. At the moment FDA approval translates to billion dollar valuations because it comes with the defacto mandate third parties pay. Third party payment is you .. you pay that in the form of taxes/health insurance premiums. A world where you try whatever you want and funding comes from private foundations if blue cross decides not to cover something makes it a lot harder for @AppleHelix @MartinShkreli et al to get a return on their investment. Ignore the noise , that’s really what this is about

@matthewherper Are you saying the pre-Makary FDA was ideal? Reality is the FDA needs massive change. I understand if u think Makary wasn’t the vessel, but he was directionally correct.

Marty Makary was the worst FDA commissioner in 25 years. Full stop. I have covered the FDA for that long, and I don’t say this lightly. He was, largely, an agent of chaos because he didn't understand the agency he was trying to lead. My story explaining is in the next post.

@SamDavisEsq USA solution starts with capital efficiency/rationality- no more setting $2B on fire on bad business plans like at EQRX.

$600M up front + biobucks up to $15.B total. It’s 2026 and Big Pharma is handily beating China touring VCs to the punch and getting the drugs directly vs the dilutive, expensive and oft inefficient newco arbitrage models. There is a solution for US to compete - and no Biosecure Act saber rattling isn’t it. AI, Automation, bet on next gen founders, ween out journeymen execs with tired playbooks.

@ajlamesa Upgrading from 80mph->100mph cost from $1m to $20M/mile. A new mile of HSR is $150m-$250M (all figs per Grok.) Using the mean point, I can upgrade 1,904 mi for the cost of 200mi of HSR. Kicker: Acela HSR averages only 25 mph more than reg Amtrak….

@PlayballTim because we are a huge country and some corridors should have true high-speed rail with improved regular-speed rail complementing the HSR

High-speed rail corridors that I would prioritize for the United States (in order of prioritization): 1) DC - Philadelphia - NYC - Providence - Boston 2) Chicago - Milwaukee - Madison - Minneapolis 3) San Diego - Los Angeles - San Francisco 4) Portland - Seattle - Vancouver (Canada) 5) Miami - Orlando - Tampa 6) Dallas - Austin - San Antonio - Monterrey (Mexico)

@ajlamesa Just invest in projects to accelerate current train lines. Look at the S-Line proj in NC which will cut train times between Raleigh &Richmond by 1hr.

@AndySwan Sony?

I'm going to invest a lot of money in a company that *everyone bought at least one product from *was basically murdered by the iPhone *might go bankrupt in the next 2 years *is down 95% from highs *has 20x upside if their hidden pivot is successful I'll Venmo 20 shares worth to the first person to guess the ticker

@dr_alphalyrae @AppleHelix ~$300M fund strategy is more/less same as the mega funds, just w/less capital. W/$300M there is big value to be created (as you said, the science is great) but need different playbook.

turning out that the biotech winter is not temporary, not thawing when rates drop. We are in a structural consolidation where sub $300M funds doing early stage discovery seem to be hollowing out. I doubt the science has gotten worse. The funding architecture around it has become increasingly inhospitable to anyone who isn’t already at scale. That is a long term problem for therapeutics discovery even if mega fund IRRs look fine in the near term

@GfedGoCrazy Anything worse than the convertible field next to the trailer n tracks at Randolph-Macon?

You want the popular answer or are we digging into the depths of FCS horrors?

@mukundiyngr With a few exceptions, the NIH is a great funder of research but a bad drug developer, and development is >80% of the value.

Every cancer drug you prescribe today was once an NIH grant nobody noticed. Pharma celebrates launches. Few notice the 20–40 year runway behind that. Gleevec took 41 years from NIH-funded discovery of the Philadelphia chromosome → FDA approval. Behind every “breakthrough” sits a graveyard of failed attempts that made it possible. Cut that lineage today, the next Gleevec doesn’t arrive in 2067. Funded science matters. If someone says NIH funded science is inefficient, show them this. - - - - - Source: NIH RePORTER · FDA · via @Jori_health - - - - -

Reposting not as a political statement but rather because Marco Rubio’s articulation of America’s character needs to be heard far and wide.

@ncsuian @WFHAGM @Canes Best idea I’ve heard: where 40 & 540 meet between the airport and RTP. Central for Triangle, good access for day trippers from west (G’boro).

@WFHAGM @Canes Where is the new MLB park going?

Remember friends, Tom Dundon wants to put a gambling center and low income apartment next to CF/Lenovo for a more “immersive atmosphere” This is gonna ruin the area for families. The @Canes hate your kids because they don’t drink enough beer at games.

@TheWildUte @RockandRant @CFBXpress @TheCFBMafia Would need to pay $$ to fill our schedule - Much easier with 11 teams to play 10 conf games.

If I'm consulting the ACC's 8 most valuable football brands, I tell them to stop subsidizing the rest. FSU. Miami. Clemson. UNC. GT. NC State. VT. Louisville. Form your own sub-conference immediately. Play each other only. Data breakdown 👇 youtube.com/watch?v=FdLxgA…

@noah_teague1 Ultimately would love to see a division of Atlanta, Charlotte, Miami, Nashville, and Raleigh. Would be epic.

Potentially. North Carolina is a great state for baseball and the city is growing. However I think Raleigh would be a better fit. The triangle is rapidly growing, further away from Braves country, and as evidenced by the Canes a hunger for pro sports.

@noah_teague1 @lambertmeltonnc Just spitballing here, but what about “Durham Bulls?”

@lambertmeltonnc It’s time for pro baseball in Raleigh. Call them something like the Carolina Reapers and it’ll be great for Raleigh, the state, and MLB.

@ashkan Teams can veto any expansion candidate w/in 35 miles, but otherwise conflict is over TV rights, which gets worked out pretty cleanly, so ultimately the “proximity to other MLB teams” isn’t a big deal. Owners vote for risk-adjusted cash flow, primarily.

@ashkan Ashkan, I like your analysis, but 2 things to think on: 1) all analysis must be risk-adjusted. Not everyone will hit 100% of rev or profit projections, (see MIA for example) 2) MLB considers markets based on 150mile radius. (Cont’d).