Domenico Pontillo

🚨 Our fantastic #RCT just published in @NEJM! 🚨 🩸 Can Acute Normovolemic Hemodilution (ANH) reduce RBC #transfusion in cardiac surgery? 🫀 ❓ What were the results? Click to find out 👉 nejm.org/doi/full/10.10… #CardiacSurgery #NEJM #PerioperativeCare

🚨 New publication alert using TriNetX real-world data 👥 >100,000 young adults with septic shock ⚖️ Propensity-matched cohort ♀️ Women aged 18–55 had lower 28-day mortality than men: RR 0.92 (95% CI 0.89–0.95) ⏳ After age 55, this difference disappeared 🔗doi.org/10.1016/j.jcrc… @JCriticalCare @giovannilandoni @alebelletti1 @SFresilli @RosaLabanca5 @mariottichia_ #TriNetX #RealWorldData #SepticShock #CriticalCare

The #PROGRESStrial protocol is out: an ongoing multicenter RCT testing whether a prehabilitation program can reduce major postoperative complications and facilitate recovery in patients undergoing major oncological gastrointestinal surgery. 🏋️‍♂️ 🔗 pubmed.ncbi.nlm.nih.gov/41621468/

This article on #AMINOACIDS for prevention of #AKI is more important than our @NEJM Hundreds of centers which are implementing perioperative AA based on the #PROTECTIONtrial and European guidelines should limit the duraton of infusion of AA to<=48 h authors.elsevier.com/a/1mg9T1dCE0RnE

Today at #ITACTAIC2026 in Bologna, great insights on the “hub & spoke” model for cardiogenic shock, current evidence and future perspectives to build faster, more integrated, multidisciplinary networks 👏 @MarinaPieri5

In this secondary analysis of the #PROTECTIONtrial, the renal protective effect of amino acid infusion after cardiac surgery was similar in diabetic and non-diabetic patients, supporting its use for all patients undergoing cardiac surgery. 🔗 pubmed.ncbi.nlm.nih.gov/41511746/

Domani verrà pubblicato su YouTube e Spotify il primo episodio di PodcAnest, un podcast sviluppato dal CPAR a cui ho collaborato Lo scopo di spiegare il mondo dell’Anestesia e Rianimazione ai non medici e agli studenti di medicina Il primo episodio parlerà di Donazioni d’organo

In our meta-analysis including 34 trials and >5000 patients, ANH did not reduce the proportion of cardiac surgery patients who received allogeneic pRBC transfusions during the postoperative hospital stay 🩸 📎 @BJAJournals pubmed.ncbi.nlm.nih.gov/41558891/

🎉 Congratulations to the Xijing Hospital: top 2026 enrolling center in the #LUNAtrial! Thank you to the ACRC & the Cardiac Anesthesia Team for their outstanding work. Special recognition to Prof. Chong Lei, PI, for exceptional leadership in high-quality clinical research!

🫀Just published in @BJAJournals Our meta-analysis of 17 RCTs (n=3,813) shows no reduction in allogeneic pRBC transfusion with #AcuteNormovolaemicHaemodilution vs standard care (40% vs 43%; RR 0.94, 95%CI 0.85-1.02; I² 80%) Don't miss the full-text kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… #ANH

Bayesian statistics for clinical research: ❓what is the Bayesian statistical framework and how does it work? ⚖️ Bayesian vs frequentist statistics: fundamental conceptual differences 🔍 specifying prior distributions 🔮 interpreting posterior distributions 🖋️ drawing conclusions from Bayesian analyses ❓what difference does Bayesian thinking make? interpretation & design of clinical trials, Bayesian hierarchical models Owing to its fundamentally different conception of probability, Bayesian statistics offers an intuitive, flexible, and informative approach that facilitates the design, analysis, and interpretation of trials. 🔗 bit.ly/3Zk2i0Q

In diabetic pts from the #PROTECTIONtrial, #AminoAcids infusion showed a 97.5% posterior probability of #AKI reduction The AA beneficial effects don't change in high risk pts! Dozens of centers worldwide are already implementing AA in routine clinical practice! What about you?⬇️

💊Antifibrotic drugs like Pirfenidone & Nintedanib decrease mortality by 40% in Acute Lung Injury patients (such as COVID-19)! 🏥This Meta-analysis suggests that this therapy could greatly benefit ALI patients: NNT=13! ⁉️Could this change post-ICU care? What do you think? Read more: signavitae.com/articles/10.22… #AntifibroticTherapy #AcuteLungInjury #PulmonaryFibrosis #COVID19 #CriticalCare #MedicalResearch #ICU #MetaAnalysis #Perfenidone #MedEd #MedTwitter

Drug of the Year 🏆 Clevidipine demonstrated superior efficacy compared with nitroglycerin for blood pressure control during carotid endarterectomy. Proud of this publication and excited to use such an outstanding medication in clinical practice. 💉✨ pubmed.ncbi.nlm.nih.gov/41392146/

𝐒𝐞𝐫𝐢𝐨𝐮𝐬 𝐬𝐜𝐢𝐞𝐧𝐜𝐞. 𝐔𝐧𝐞𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐟𝐨𝐫𝐦𝐚𝐭. The @ISICEM Critical Care Input — presented this time in a new way. Watch it now and enjoy. Credits @DrFDamico #ISICEMelearning @NEJM Full article nejm.org/doi/full/10.10…

🏥 San Raffaele lancia il corso per professionisti dedicato alla pre-abilitazione preoperatoria 📣 🏃‍♂️ Attività fisica e valutazione funzionale 🥗 Ottimizzazione nutrizionale 🧠 Preparazione psicologica e gestione dello stress 👉 per migliori outcome postoperatori 🎓 Per fisioterapisti, nutrizionisti, psicologi e medici. unisr.it/offerta-format…

💰 Intravenous amino acids work—and they save money A new multi-country economic evaluation shows AA infusions are both cost-saving and cost-effective in preventing AKI after cardiac surgery. 🔗 Help us map all AA solutions available: docs.google.com/forms/d/e/1FAI…

MY FAVOURITE PAPER published today in @JCVAonline will be presented this afternoon in Valencia @EACTAIC congress with @gudokunst available here doi.org/10.1053/j.jvca…

How to prevent AKI postoperatively? ➡️ Liberal crystalloids & amino acids ↓ AKI risk post cardiac surgery ➡️ Restrictive fluids & hyperoncotic albumin ↑ AKI risk ➡️ SGLT2 inhibitors protective; ACEi/ARB continuation safe CCR Journal Watch criticalcarereviews.com/latest-evidenc…

Esmolol reduces low cardiac output syndrome @MRE_signavitae @giovannilandoni signavitae.com/articles/10.22…

So great to have this brief lesson for @SRAnesthesiaICU trainees and @MyUniSR students!