popo

29 posts

popo banner
popo

popo

@PopoMicro

Bacterial transposons; Tn7-like elements; CRISPR; 🇹🇼

Katılım Haziran 2018
142 Takip Edilen121 Takipçiler
popo
popo@PopoMicro·
With ~1/3 of Streptomyces genomes carrying telomeric transposons, these elements compete for the same niche. Identical transposons in different telomeres, both within and between genomes, are occasionally found to be disrupted by other transposons, indicating fierce competition.
popo tweet media
English
1
0
1
97
popo
popo@PopoMicro·
TnsBC telomeric transposons are highly diverse, with distinct gene repertoires. Surprisingly, one subgroup includes the Type I-E Cascade + tnsBC system. The tnsBC was initially thought to replace Cas1-Cas2. Spacer analysis supports their telomeric role, often targeting ttrA.
popo tweet media
English
1
0
2
96
popo
popo@PopoMicro·
In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons. doi.org/10.1126/scienc… @JoePetersLab @BarabasGroup
English
1
5
19
2.2K
popo retweetledi
Joseph E. Peters
Joseph E. Peters@JoePetersLab·
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.110…
English
1
26
115
11.7K
popo retweetledi
Yao Shen
Yao Shen@shen_yao10·
Excited to share our recent findings on Tn7 and its fascinating targeting mechanism, now published in Molecular Cell! 🧬🔬Check it out sciencedirect.com/science/articl…
Alba Guarne@alba_guarne

Happy to share that our last story on Tn7 is finally out. Another example of @shen_yao10 talent and a great collaboration with @JoePetersLab @MikePetassi Assembly of the Tn7 targeting complex by a regulated stepwise process sciencedirect.com/science/articl…

English
2
2
13
1.7K
popo retweetledi
Joseph E. Peters
Joseph E. Peters@JoePetersLab·
It was a pleasure working with @PopoMicro on this review of CRISPR-Cas associated transposons (CAST). Hopefully it gives a sense for the diversity of Tn7-like transposons and CRISPR systems that independently combined.go.shr.lc/444PwFh
Joseph E. Peters tweet media
English
2
41
117
11.6K
popo
popo@PopoMicro·
Hats off to the brilliant minds at Feng lab and Gootenberg lab for their awe-inspiring research achievement! (What a competitive field, people always have manuscripts ready at about the same time) biorxiv.org/content/10.110…
Feng Zhang@zhangf

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

English
0
0
5
858
popo
popo@PopoMicro·
@JoePetersLab We thank Dr. Pietrasiak for providing the strain used in this work from the Terrestrial Cyanobacterial Culture Collection (NuMex TCCC). The frozen cell mass sent by Dr. Pietrasiak was even alive! Tough dessert cyanobacteria! @DrylandAlgae
popo tweet mediapopo tweet media
English
1
1
6
698
popo
popo@PopoMicro·
Our small discovery just got published 😇. Relatively few cyanobacterial genomes are home to most known families of CRISPR-Cas transposons (CAST). After a careful search, we found a new capture: type I-D CAST~ academic.oup.com/nar/advance-ar… @JoePetersLab
popo tweet media
English
7
14
85
12.7K
popo
popo@PopoMicro·
PI is bullied!
popo tweet mediapopo tweet mediapopo tweet mediapopo tweet media
Nederlands
1
0
2
302
popo
popo@PopoMicro·
Peters lab having fun with snow ~~
popo tweet mediapopo tweet mediapopo tweet mediapopo tweet media
English
1
0
6
1.7K

Keşfet

@JoePetersLab @BarabasGroup @MachadoChacon @DrylandAlgae @kellogg_liz @Nancy_Craig777 @alba_guarne @PhoebeARice