Susanne

Wow!! nature.com/articles/s4146…

Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs - now published in Chemical Science pubs.rsc.org/en/content/art…

Read our @NaturePortfolio Behind the Paper blog post on our recent work on photoaffinity-based fragment libraries here: communities.springernature.com/posts/photorea…

'These findings imply that vascular anatomy sets a resolution limit on functional imaging signals... individual blood vessels inaccurately report neuronal activity in their immediate vicinity ...' nature.com/articles/s4159…

Our perspectives on the various aspects of bias in GPCR function, with a special focus on their relevance to the kidney, have been published in @NatRevNeph. nature.com/articles/s4158…

Astonishingly, differences in beta-arrestin recruitment almost completely disappeared without endocytosis. Since beta-arrestins form stable interaction with AT1R, even at endosomes, we speculated that agonist-specific differences occur endosomally.

A new paper shows that the #endocytosis of #GPCRs such as AT1R can influence biased signaling through #BetaArrestin, suggesting the efficacy of beta-arrestin-binding ligands depends on spatial location as much as on receptor conformation. @semmelweishu scim.ag/7th

Research reveals how location within cells can influence the phenomenon of biased signaling, a Focus dissects recent research spotlighting a potential target for cognitive enhancement, and more in the new issue of #ScienceSignaling. scim.ag/7so

Congratulations to @katonalab and colleagues on their new article! They combine #Electrophysiology and correlative #Confocal and #SuperResolution #Microscopy to identify and study single synapses, providing insights into retrograde cannabinoid signaling: bit.ly/4eaXCB0

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins dlvr.it/T71kbZ

DSI is a form of synaptic plasticity mediated by endocannabinoids (eCBs). With @LinlinZFan, we demonstrated in vivo that place cell activity triggers eCB signals affecting GABAergic inputs; and that cannabinoid receptors modulate place cell tuning. science.org/doi/10.1126/sc…

I had read a paper on GPCRs and arrestins in @jbiolchem several years ago and sent a congratulatory note to the authors. I met the 1st author in Budapest last week and he mentioned how motivating that email was to him and inspired him to continue in this field. #Win#For#Science.

A few years ago, I conducted an experiment with an endocytosis inhibitor that completely changed my understanding of signaling bias. We dove deeper into the spatiotemporal aspects of bias. See our @biorxiv preprint for more: biorxiv.org/cgi/content/sh… #GPCR #signaling #pharmacology

Excited to share our recent review in @FrontSystemsBio, which highlights the use of perturbation gene expression profiles to connect causal perturbations to gene expression changes for drug discovery applications. frontiersin.org/articles/10.33…

We congratulate our colleague, Péter Ábrányi-Balogh, for his recent achievements: in addition to being promoted to senior research fellow, Péter was recently awarded with the Zemplén Géza Prize for his work in organic and medicinal chemistry! 👏👏

Can we identify common mechanisms behind antiviral drug effects by analysing drug and SARS-CoV-2 induced gene expression signatures? Our latest project, led by @BarsiSzilvia is now published in @PLOSCompBiol: journals.plos.org/ploscompbiol/a…

Just in time before the holidays! Congrats @AndrasDToth for your presentation @DrGPCR Summit! Enjoy the goodies! #gpcr #drgpcr

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo #PKU go.nature.com/31UuKfy

The opening keynote session of the #CannabinoidGRC is in full steam, so great to see science in person @zenbrainest @HurdLab @katonalab

A systematic review presents evidence that psychosocial interventions for adults with schizophrenia improve functional outcomes, quality of life, and core illness symptoms. Read more: bit.ly/3lq6ZlN