The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study
thelancet.com/journals/lanhl…
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Pyry Sipilä
21 posts
Pyry Sipilä
@PyrySipila
Epidemiologist
University of Helsinki Katılım Mart 2012
16 Takip Edilen9 Takipçiler
The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study journals.plos.org/plosmedicine/a…
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Adult obesity and risk of severe infections: a multicohort study with global burden estimates - The Lancet thelancet.com/journals/lance…
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A study finds that eating disorder patients with type 1 diabetes receive hospital treatment for their eating disorder less often than those eating disorder patients who do not have diabetes. link.springer.com/article/10.100…
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Association of LEAF-Q and EDE-QS scores with cholesterol levels in Finnish female athletes bmjopensem.bmj.com/content/10/3/e…
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Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline
nature.com/articles/s4358…
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Proud of PhD student Leon Hirvelä from our department, whose paper about broad eating disorder symptoms and alcohol problems was published on Friday. onlinelibrary.wiley.com/doi/10.1002/ea…
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Predicting long-term risk of #dementia for cognitively healthy individuals is challenging. Error rates are very high even with the risk scores currently used in research and health care.
@Gill_Livingston @epiAgeing @PyrySipila
jamanetwork.com/journals/jaman…
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#ICYMI: Severe Infection and Cardiovascular Disease @PyrySipila @MikaKivimaki @uk_biobank @wellcometrust #AHAJournals
Circulation@CircAHA
#OriginalResearch: In this multicohort study, hospital-treated infections associated w/ significant increase in short-term risk and modest long-term risk of major CVD events. @MikaKivimaki @nellimarikki@PyrySipila #AHAJournals ahajrnls.org/40oqjCY
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#OriginalResearch: In this multicohort study, hospital-treated infections associated w/ significant increase in short-term risk and modest long-term risk of major CVD events. @MikaKivimaki @nellimarikki@PyrySipila #AHAJournals ahajrnls.org/40oqjCY
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This massive study combined evidence for the link between autoimmune diseases and dementia using 6 different big-data approaches.
The work was lead by @jlindbohm and @ninajmars with contributions from @pyrysipila, @heikorunz, @Gill_Livingston, Ramnik Xavier and many others
Mika Kivimaki@MikaKivimaki
@NatureAging: Further evidence that Alzheimer’s is an autoimmune disease. Study also suggests anti-inflammatory drugs, such as methotrexate might prevent dementia. #Triangulation #MendelianRandomization @FinnGen_FI @Whitehall2study @JoniLindbohm @samrip rdcu.be/cXzOp
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Observational evidence suggests:
–#Obesity decreases disease-free years much more than longevity.
–The proportion of #multimorbidity by age 75 in people with healthy weight was reached already by age 55 in those with obesity.
#multicohort #UKBiobank
thelancet.com/journals/landi…
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Pyry Sipilä retweetledi
What causes dementia? 2 studies using retrospective cohort data find that risk of developing #dementia increases after having a serious #infection. What does this mean for #LongCovid?
@TheLancetInfDis bit.ly/3e9ytZV
@LancetLongevity bit.ly/2VzObXS
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If anti-amyloid drugs do not prevent clinical dementia, what are the alternatives? This paper identifies 15 new protein targets for #dementia drug development.
#Whitehall study #ARIC study
@jlindbohm @gill_livingston @gottesman_lab
alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
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New research Article: Hospital-treated infectious diseases and the risk of #dementia: a large, multicohort, observational study with a replication cohort 🇫🇮🇬🇧 thelancet.com/journals/lanin…
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Multicohort study links #infections to #dementia risk:
- stronger effects on vascular dementia than Alzheimer’s
- attributable to general inflammation rather than any specific pathogen
- systemic infections sufficient to affect the brain.
@UK_Biobank
thelancet.com/journals/lanin…
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Amyloid and tau have dominated pathophysiological models of dementia aetiology.
This preprint identifies 15 novel proteins associated with cognitive decline and dementia.
@Whitehall2study #ARIC @JLindbohm @gottesman_lab @epiAgeing @Gill_Livingston
medrxiv.org/content/10.110…
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For comparison, mild traumatic brain injury with loss of consciousness is also associated with a ~2-fold increase in the risk of dementia diagnosis
ja.ma/3jS9drA
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NEW multicohort study: #BingeDrinking a long-term #dementia risk factor even if a person usually drinks moderately.
Alcohol-induced loss of consciousness linked to a 2-fold increased dementia risk among both moderate and heavy drinkers.
ja.ma/32dDz1G
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Pyry Sipilä retweetledi
Risk factors, such as hypertension, obesity and physical inactivity are targets of #dementia prevention. New research suggests that many inflammatory diseases (gastritis, duodenitis, erysipelas) may be equally strong long-term predictors of dementia. alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
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