Rotimi Mesubi

@temidayo @LondonMarathon @WMMajors @nycmarathon Way to go! You are an inspiration!

So this happened a couple of weeks ago.... Completed @LondonMarathon and got my @WMMajors six-star medal. I started the journey with the @nycmarathon in 2014 and I'm thankful I've remained healthy enough to keep running. 🏃‍♂️🏃💨

@VirginiaSHahnMD @JR_Goldenberg Congratulations

Congrats @JR_Goldenberg on this fantastic paper! We need better tools to identify who will recover their EF

@UREssien You did not disappoint with the bow- ties!!!

Just like that, its a wrap for #AHA23! 🫀 Promise I got to share some science amid all the selfies too! 👨🏾‍⚕️ Last conference of 2023. Look forward to brainstorming some new big things in the new year. 🧑🏾‍🔬 Really great catching up with so many friends & colleagues this weekend. ✌🏾

@GbengaOgedegbe @AHAScience @nyulangone @pophealthNYC @nyugsom_iehe @nyugrossman @American_Heart Congratulations!

@AHAScience @nyulangone @pophealthNYC @nyugsom_iehe Truly an honor to receive this award with gratitude to my team @nyugsom_iehe @pophealthNYC @nyulangone @nyugrossman and the communities and study participants who made this possible. 🙏🏾 @American_Heart

Congratulations to the award winners at #AHA23! We are grateful for your dedication, impact, and service to the field of medicine.

Congratulations to @Oscarreyesgaido, winner of this year’s AHA Katz Basic Science Research award and to our indefatigable mentor Dr. Mark Anderson. Looking forward to more Katz and Marcus AHA winners from this pedigree! @priyaumapathi @KlitosKon @betsy_luczak

There’s worry about what the Supreme Court’s ruling on affirmative action could mean for the pipeline of who eventually provides health care in the U.S. For more on these concerns, @IAmAmnaNawaz spoke to @UREssien. to.pbs.org/3MzB3rB

@CardioNerdsJC Negative studies are still useful for providing information and prevents others from making the same assumptions

➡️Any final thoughts on the RAPID-HF trial? 🤔 #CardsJC

@yreddyhf @CardioNerdsJC Still begs the question - what do you do in HFpEF patients with symptomatic bradycardia/SND

@CardioNerdsJC There was no RCT data to support the original recommendation for pacing for chronotropic incompetence in the first place. We think the trial results support not exposing patients to the risk and burden of a pacemaker given lack of efficacy in HFpEF with limited peak HR. #CardsJC

➡️How will the results of the RAPID-HF trial affect your clinical practice?🤔 ➡️How will these results affect your interpretation of the IIa, C-EO recommendation for atrial-adaptive pacing for chronotropic incompetence?🤔 #CardsJC

@RyanTedfordMD @CardioNerdsJC This brings up another issue - HFpEF is a heterogeneous disease, yet we keep treating it as one disease. Maybe sub-populations of HFpEF patients stand to benefit or suffer harm.

@CardioNerdsJC And finally, would the results be different in the cohort was enriched for HFpEF and RV failure phenotype? #CardsJC pubmed.ncbi.nlm.nih.gov/33026819/

RAPID-HF results showed: ⬆️ increase in exercise HR ↔️ no change in VO2AT, VO2, or QoL ➡️What might explain this discrepancy? 🤔 #CardsJC

@CardioNerdsJC The incidence of adverse outcomes seems relatively high in this study. #CardsJC

6 out of 29 patients experienced an adverse event related to the pacemaker, including a pericardial effusion requiring pericardiocentesis. ➡️How do these adverse outcomes affect your overall interpretation of the results?🤔 #CardsJC

@EJSMD @rdschaller In this study, it will also have been difficult to determine if symptoms were due to SND vs HFpEF. #CardsJC

@rdschaller Many long sinus pauses don't need pacers. Often vagal & benign. Don't even get me started about nocturnal pauses. Many people don't know there's no indication for pacing in SN dysfunction without symptoms. HR could be 20, pause 10 sec. Unless sx, no pacer indication. #CardsJC

I think that there is likely a very big placebo effect for PPMs placed for SND #CardsJC

@CardioNerdsJC The authors suggest this was done to as a measure of sub maximal exercise performance more representative of ADLs. #CardsJC

1⃣ Primary End Point: O2 consumption at anaerobic threshold (VO2AT) 2⃣ Secondary End Points: 💠peak VO2 💠ventilatory efficiency 💠KCCQ-OSS 💠NT-proBNP ➡️Why did the authors choose VO2AT as the primary endpoint as opposed to peak VO2? 🤔 #CardsJC

@OscarIReyes1 @NkashamaLubika @DrDiastole

An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor | Science Translational Medicine science.org/doi/10.1126/sc…

1/ 🧵 NEW Paper. In @JAMACardio we asked: are there racial/ethnic disparities in treatment & outcomes in the Get With the Guidelines - AFIB Registry. Short answer: YES. Here’s what we found, what it means, and what we can do to achieve #Pharmacoequity. jamanetwork.com/journals/jamac…

@LarryRJacksonII @gdelriopertuz @CardioNerdsJC That's a study waiting to be done! #CardsJC

@gdelriopertuz @CardioNerdsJC Great point. Does screening followed by intervention (OAC) actually change hard outcomes? #CardsJC

What are potential future trials that may stem from this trial? Different populations/subsets? Different screening modalities outside of single lead ECG? Longer follow-up time? #CardsJC

Based on the data in this paper, there is not enough evidence for routine screening, especially with the Kardia device at a clinic visit to a primary care visit. #CardsJC

In addition to cost issues with continuous monitoring of ECG, there is the administrative and clinical burden of the data overload. #CardsJC

@KTamirisaMD @HafizaKMD @RajendraPShahMD @CardioNerdsJC I think the brings up two issues - 1) Access to care 2) Quality of care, when there is access. Presumably a good quality physical exam (for pulse) vs ECG vs a device like Kardia will give approximate results (don't have any data on this!)

@HafizaKMD @RajendraPShahMD @CardioNerdsJC You bring a good point @HafizaKMD one large academic system. #cardsJC These are expensive for those who can’t afford insurance or lack health literacy #CardsJC

Data on race/ethnicity was not collected. How do you think this could have affected the outcomes❓ #CardsJC

The average BMI in this study was ~ 28. This is certainly much lower than I see in my practice and may have also affected the outcomes. Obesity is a known risk factor for AF. I may send my patients to MA for weight loss therapy! #CardsJC