David Kuster

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/sc…

Our linker histone H1 paper is featured on the cover of the April 10 issue of @ScienceAdvances. science.org/doi/10.1126/sc… A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: science.org/toc/sciadv/12/…

New research shows “pearling” — a constriction of mitochondria — drives distribution of mitochondrial DNA nucleoids, helping ensure proper genetic organization and inheritance within cells. 🧬 science.org/doi/10.1126/sc…

The Focus issue features views from redox biologists on the next frontiers and most needed developments in the field nature.com/articles/s4158… Free to read link: rdcu.be/fbdwd

A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms: journals.plos.org/plosbiology/ar…

We are hiring a research assistant for the lab! Come join us if you are excited about cell cell interactions in the gut, genetics and imaging!  Deadline: 15 th March Apply here  nature.com/naturecareers/… #oxford #Hiring #pombogarcialab

My student @Aoi_Otsuka_’s PhD work is now officially published @CSF_JSCB! 🔬Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! 👏 jstage.jst.go.jp/article/csf/51…

The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/3NKZXJQ

Organelle biogenesis on a synthetic bead: biorxiv.org/content/10.648…

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues biorxiv.org/content/10.648…

Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure. Learn more in a new #SciencePerspective: scim.ag/48FsaIR

Proximal proteomics reveals a landscape of human nuclear condensates: nature.com/articles/s4155…

@Absolutenivlek Not sure what to think of papers that fail to include Pinocytosis though... @Absolutenivlek

@RNADavid 👀

Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. sciencedirect.com/science/articl… 🧵a thread

🛡️”The Iron Dome”🛡️ Under alcohol stress, a slime mold rapidly retracts into a sclerotia of thousands of hexagonal spherules, sealing so tightly that Dextran-FITC (cyan) can’t enter. Captured by me at the MBL Physiology Course (Gladfelter Lab rotation). #MBL #Microscopy

@Akruidhof00 This is AI generated, the depicted bird species does not exist.

@PierreHugot6 @Akruidhof00 Not at all, these are AI generated and the species doesn't exist in nature

@Akruidhof00 Took me a while but these are wire tailed SWALLOWS, definitely not kingfishers. ebird.org/species/witswa1

Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s4158…