David Kuster

We are hiring a research assistant for the lab! Come join us if you are excited about cell cell interactions in the gut, genetics and imaging!  Deadline: 15 th March Apply here  nature.com/naturecareers/… #oxford #Hiring #pombogarcialab

My student @Aoi_Otsuka_’s PhD work is now officially published @CSF_JSCB! 🔬Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! 👏 jstage.jst.go.jp/article/csf/51…

The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/3NKZXJQ

Organelle biogenesis on a synthetic bead: biorxiv.org/content/10.648…

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues biorxiv.org/content/10.648…

Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure. Learn more in a new #SciencePerspective: scim.ag/48FsaIR

Proximal proteomics reveals a landscape of human nuclear condensates: nature.com/articles/s4155…

@Absolutenivlek Not sure what to think of papers that fail to include Pinocytosis though... @Absolutenivlek

@RNADavid 👀

Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. sciencedirect.com/science/articl… 🧵a thread

🛡️”The Iron Dome”🛡️ Under alcohol stress, a slime mold rapidly retracts into a sclerotia of thousands of hexagonal spherules, sealing so tightly that Dextran-FITC (cyan) can’t enter. Captured by me at the MBL Physiology Course (Gladfelter Lab rotation). #MBL #Microscopy

@Akruidhof00 This is AI generated, the depicted bird species does not exist.

@PierreHugot6 @Akruidhof00 Not at all, these are AI generated and the species doesn't exist in nature

@Akruidhof00 Took me a while but these are wire tailed SWALLOWS, definitely not kingfishers. ebird.org/species/witswa1

Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s4158…

Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of nucleocytoplasmic transport: pnas.org/doi/10.1073/pn…

Nucleic acid-protein condensates in innate immunity: Molecular Cell cell.com/molecular-cell…

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @VirusesImmunity. princeton.edu/news/2025/09/1… #KeioMedicalSciencePrize

Accurate prediction of thermoresponsive phase behavior of disordered proteins - Chakravarti - 2025 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/pr…

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views | Cell Amazing review by @HentzeTeam et al.! cell.com/cell/fulltext/…