Finn Rabe

New preprint out and featured by @newscientist: Even forgotten memories shape your choices! Our results reveal how hidden memory traces in the brain keep influencing your behavior—read more here: doi.org/10.1101/2025.0…

Genetic risk for schizophrenia is associated with lower retinal thickness. 🧵1/9

Our new paper is featured on the cover of the May issue of @NatMentHealth !🖼️ Read more about how the retina changes with increasing risk for schizophrenia: nature.com/articles/s4422…

A study in @NatMentHealth explores the relationship between the genetic risk for schizophrenia and retinal thickness, demonstrating that neuroinflammatory pathways are linked to retinal thinning, with C-reactive protein partially mediating this effect. go.nature.com/3RIQ9io

Schizophrenia Symptoms Linked to Unique Brain Structures A large international study has revealed that schizophrenia manifests differently in brain structure, explaining why symptoms vary widely among patients. Researchers analyzed brain scans from over 6,000 individuals and found that while some brain regions showed high variability, others remained strikingly uniform. The mid-frontal region, responsible for linking thought and emotion, had consistent folding patterns across patients, suggesting less flexible brain development in early childhood. This rigidity may contribute to the common cognitive and emotional challenges seen in schizophrenia. Meanwhile, differences in cortical thickness and surface area across individuals may explain why some patients experience perceptual disturbances while others face cognitive impairments. These findings highlight the potential for precision medicine approaches that tailor treatments based on each patient’s neurobiological profile.

We would like to thank everyone from the @enigmabrains consortium who contributed to this insightful work. The study has featured as an article in UZH News: lnkd.in/euyuXmkw

Unexpectedly we found that cortical folding of the right anterior cingulate cortex was more uniform in schizophrenic individuals than in controls. This reduced variability may indicate a less flexible interplay between genetic and environmental factors during neurodevelopment.

Our latest paper in which we investigate structural brain variability in schizophrenia in thousands of brains from the @enigmabrains dataset has been published in the American Journal of Psychiatry @APAPubJournals: psychiatryonline.org/doi/10.1176/ap…

Unsere Retina-Forschung für die Schizophrenie sehr verständlich übersetzt: Danke @ChristinaBerndt @SZ für das Interesse in unsere Arbeit🙌 sueddeutsche.de/gesundheit/psy…

The genetic risks for schizophrenia and multiple sclerosis affect specific retinal cells, suggesting the retina can be used to study these brain disorders. ja.ma/3E0M6u0

Our new📜@JAMAPsych shows that different retinal cell types are affected by the genetic architecture of #Schizophrenia and #MS and highlights the potential of 👁️as a proxy to study synaptic impairment in SCZ👉bit.ly/Retina_SCZ Tx🙏@mpi_psychiatry @LMU_Uniklinikum @UZH_ch

Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank medrxiv.org/cgi/content/sh… #medRxiv

A special thanks to Lukasz Smigielski and @philipphoman for their amazing work and to our coauthors @ToddLencz, @FivosGeorgiadis, @KallenNils, Edna Grünblatt, Matthias Kirschner, , @WOmlor for their great contributions

Read more about this in our new preprint doi.org/10.1101/2024.0… on @medrxivpreprint

Did you know that the retina is part of the central nervous system (CNS)? And that you can measure subtle neuronal changes by imaging it? You can do this with optical coherence tomography (OCT) within a few minutes.