Philipp Homan

🦋Our May issue is now live!🦋 👁️Take a look at our new articles on #OCD, #depression, hearing loss, loneliness, #psychedelics, schizophrenia & more! Cover design: @Marina_C_Spence nature.com/natmentalhealt…

A study in @NatMentHealth explores the relationship between the genetic risk for schizophrenia and retinal thickness, demonstrating that neuroinflammatory pathways are linked to retinal thinning, with C-reactive protein partially mediating this effect. go.nature.com/3RIQ9io

“Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study” by Philipp Homan et al. American Journal of Psychiatry doi.org/10.1176/appi.a…

Schizophrenia Symptoms Linked to Unique Brain Structures A large international study has revealed that schizophrenia manifests differently in brain structure, explaining why symptoms vary widely among patients. Researchers analyzed brain scans from over 6,000 individuals and found that while some brain regions showed high variability, others remained strikingly uniform. The mid-frontal region, responsible for linking thought and emotion, had consistent folding patterns across patients, suggesting less flexible brain development in early childhood. This rigidity may contribute to the common cognitive and emotional challenges seen in schizophrenia. Meanwhile, differences in cortical thickness and surface area across individuals may explain why some patients experience perceptual disturbances while others face cognitive impairments. These findings highlight the potential for precision medicine approaches that tailor treatments based on each patient’s neurobiological profile.

Estimación de la variabilidad cerebral estructural multimodal en los trastornos del espectro de la esquizofrenia: un estudio ENIGMA a nivel mundial psychiatryonline.org/doi/10.1176/ap…

"Individuals with schizophrenia showed greater variability in cortical thickness, cortical surface area, subcortical volume, and fractional anisotropy within the frontotemporal and subcortical network" psychiatryonline.org/doi/10.1176/ap…

Our latest paper in which we investigate structural brain variability in schizophrenia in thousands of brains from the @enigmabrains dataset has been published in the American Journal of Psychiatry @APAPubJournals: psychiatryonline.org/doi/10.1176/ap…

Eine neue Studie zu Schizophrenie zeigt eine weniger flexible Gehirnentwicklung in früher Kindheit, insbesondere in Bereichen, die für die Verbindung von Denk- und Fühlvorgängen zuständig sind: news.uzh.ch/de/articles/me… @philipphoman

A new study on patients with schizophrenia finds less flexible brain development in early childhood, particularly in areas responsible for connecting cognitive and emotional processes: news.uzh.ch/en/articles/me… @philipphoman

📢 It's published!!! We (28 scientists) propose 4 Ways to increase Effect Sizes (not only Sample Size) to enhance the Replicability of Neuroimaging Research on Individual Differences. 🧠 >> check this out: doi.org/10.1162/jocn_a…

The genetic risks for schizophrenia and multiple sclerosis affect specific retinal cells, suggesting the retina can be used to study these brain disorders. ja.ma/3E0M6u0

Our new📜@JAMAPsych shows that different retinal cell types are affected by the genetic architecture of #Schizophrenia and #MS and highlights the potential of 👁️as a proxy to study synaptic impairment in SCZ👉bit.ly/Retina_SCZ Tx🙏@mpi_psychiatry @LMU_Uniklinikum @UZH_ch

New Preprint! Our latest research, led by Marlene Franz, identifies orbitofrontal cortex thickness and network alterations as transdiagnostic markers of amotivation. Big thanks to all co-authors @BorisBernhardt @sofievalk @misicbata @bttyeo @philipphoman medrxiv.org/content/10.110…

📢 😃Thrilled to share this Preprint with you‼️ We (28🧠-Scientists) propose 4 Ways to increase Effect Sizes (not only Sample Size) to enhance the Replicability of Neuroimaging Research on Individual Differences. osf.io/preprints/osf/…

My lessons learned: 1. Such in person meetings are engaging & help crafting a constitution for the lab 2. Bringing together clinicians & researchers is a challenge worth taking 3. Scientific speed dating is fun!

homanlab.github.io/blog/2024/05/2… First Homan Lab Retreat: Bringing together the lab's clinicians & researchers, we spent a whole day on teambuilding and scientific exchange. This was great @WOmlor @benjaminaston_ @KallenNils @RoyaHueppi @RabeFinn @akhilratan05 @YvesPauli & the whole team!

Read more about this in our new preprint doi.org/10.1101/2024.0… on @medrxivpreprint

Did you know that the retina is part of the central nervous system (CNS)? And that you can measure subtle neuronal changes by imaging it? You can do this with optical coherence tomography (OCT) within a few minutes.

𝗦𝘁𝘂𝗱𝘆𝗶𝗻𝗴 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗽𝗮𝗿𝗮𝗱𝗶𝗴𝗺𝘀 𝘄𝗶𝘁𝗵 𝗳𝗠𝗥𝗜? How can you detect brain states in a unsupervised manner? Come see our approach this morning at #SfN23, work by @JoyneelMisra