ton rabelink

Spatial Metabolomics Reveals Lasting Stroke Brain Changes scienmag.com/spatial-metabo…

Another Resource developed by @josh_brickman and colleagues presents a reference tool (brickman-preimplantation.streamlit.app) based on deep learning models for unbiased annotation of preimplantation embryo datasets. nature.com/articles/s4159…

World-first breakthrough! reNEW Melbourne researchers at @MCRI have created lab-grown blood stem cells resembling those in the human body. This could pave the way towards personalised treatments for blood diseases such as leukemia & bone marrow failure. 🔗 nature.com/articles/s4158… Read more: renew.science/stories/renew-…

Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of tissue is critical to tissue repair development rdcu.be/dR9WX @NatRevNeph @reNEW_Global

@twitt_login Up to 60% of the human adult body is water. However, in tissue this water is bound and associated for a big part to the polysaccharide Hyaluronan. This gel-like component of the tissue is critical to tissue repair and organ development.…rdcu.be/dR9WX

@Niels_Geijsen and Frank Staal are part of a project aiming to transform Cell and Gene Therapies. The project has been awarded €10M through the IPCEI Med4Health program and is a collaborative effort between @NecstGen , @NtransTech, @LUMC_Leiden and @divvly. renew.science/stories/e10-mi…

Nature research paper: Bridge RNAs direct programmable recombination of target and donor DNA go.nature.com/3VDSJb3

Latest in our Plasticity Project, featuring our fave cells, Primitive Endoderm (PrE), and their in vitro model, nEnd. Amazing PhD journey @MLAgerhom, contributors @AnnikaCharlott2 @albooo87 @MartaPrera @mproksik @TeresaKnudsen @MigManzanares (1/11). twtr.to/FfAst

@josh_brickman @AnnikaCharlott2 @albooo87 @MartaPrera @mproksik @TeresaKnudsen @MigManzanares fantastic!

Our review “Spatial metabolomics in tissue injury and regeneration” is now available online! sciencedirect.com/science/articl…

Terrific Nature paper that will greatly improve the analysis of spatial transcriptomic data! Working on this as an editorial advisor was a blast, and more publications are coming! I'm sure @KSusztak @HumphreysLab will like it, as well as @10xGenomics nature.com/articles/s4158…

COL4A3 and COL4A4 pathogenic variants in the normal population: redefining Alport syndrome? By Judy Savige ✏️@drvt87 #ERA24 #SoMe team 💥Time to change from Alport syndrome to Alport spectrum!! ⚡️ XL- kidney failure in males and 20% of females by the age of 60 ⚡️ AR-kidney failure in males and females ⚡️ Digenic Alport syndrome ⚡️ AD-haematuria; kidney failure is uncommon

Presented at #ERA24: In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: nej.md/4dHQhsa

Researchers have mapped a tiny piece of the human brain in astonishing detail go.nature.com/4anVZN5

New work from the @RabelinkT lab shows that a cell-free nutrient-supplemented perfusate allows 4-day ex-vivo preservation of human kidneys using spatially resolved lipidomics and metabolomics, @LUMC_Leiden, @reNEW_Global nature.com/articles/s4146….

Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. rdcu.be/dHL6W

@Boletta_Lab @ERC_Research congratulations!

🎉Beyond happy to receive an #ERCAdG! @ERC_Research QtCilia studies a novel nutrient sensing role of #cilia (@NatMetab rdcu.be/dDTn3).We will study how #cilia sense glutamine(Q) and talk to #mitochondria to regulate #metabolism. In health and disease #ciliopathies #PKD

International consensus statement published in @NatRevNeph calls for urgent action to address CKD on the global public health agenda. Read “Chronic Kidney Disease and the Global Public Health Agenda: An International Consensus” ➡️ doi.org/10.1038/s41581…

reNEW (@reNEW_Global) scientists from @LUMC_Leiden developed and validated a platform for generating GMP-compliant hiPSC lines. 🧫 The platform entails the methodology for donor recruitment, donor material procurement, hiPSCs manufacture, and more. bit.ly/4adfOqw

reNEW researchers in the @LUMC_Leiden have established an in-house platform to produce #GMP-compliant #hiPSCs. The platform is a key milestone as it allows the production of hiPSC derived cell therapy products developed in reNEW for clinical purposes. sciencedirect.com/science/articl…