Michael Ostacher, MD, MPH

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Michael Ostacher, MD, MPH

Michael Ostacher, MD, MPH

@RecoveryDoctor

Professor of Psychiatry & Beh Sciences @StanfordMed decreasing stigma/increasing evidence/improving care. Food tweets. Digital Ed @BMJMentalHealth Opinions mine

Stanford, CA Katılım Ocak 2013
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
Just had a patient tell me today that my prescribing acamprosate saved his life. Hasn't drank since. "I just don't think about it anymore." Never had someone taking gabapentin tell me that, so just a reminder to all of you out there to follow the data and to watch your biases.😀
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
@pash22 @VPrasadMDMPH If you stop eating fresh fruits and vegetable for a few weeks you are going to die prematurely of cardiovascular disease? I guess no expert is trustworthy anymore, especially the contrarian ones. He's blocked me so he won't see this explosive post, which is too bad.
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
@BadreNicolas @KwameHolmes I sometimes do this too, but you just replied to a nonsensical post. Provoked by the provocative. His account is a procession of accusations against psychiatry so you won't be winning him over.
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Nicolas Badre
Nicolas Badre@BadreNicolas·
I think people have long considered that the same crime can be punished differently depending on context. For example, we view killing in self-defense as not a crime, but another killing as murder. Psychiatry can provide context; courts make decisions. I think there are arguments that forensic psychiatry goes too far. I post about them often.
Nicolas Badre@BadreNicolas

Why did a legendary judge call psychiatrists ‘wizards’? Bazelon, 1974. After trusting psychiatry 18 years, then flipped: •Too much jargon: ‘in my experience [psychiatrists] try to limit their [opinions] to conclusory statements couched in psychiatric terminology.’ •Example? ‘Labeling a person "schizophrenic" does not make him so!’ •Too little evidence: ‘Psychiatrists have not understood is that conclusory labels are no substitute [ ] for facts derived from disciplined investigation.’ •Dishonesty: ‘Psychiatrists have justified fudging their testimony on “dangerousness” -a ground for involuntary confinement-when they were convinced that an individual was too sick to seek help voluntarily.’ •Overreach: Using a medical model for ‘social and political’ issues. •Ignorance: Applying ‘conclusory labels to [patients]-without explaining the origin, development or manifestation of a disease in terms comprehensible.’ •Fragility: ‘For monitoring the performance of a profession there is no substitute, in the end, for the adversary process.’ If Bazelon sounds anti psychiatry, maybe we should be more understanding of the critics of psychiatry.

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Crémieux
Crémieux@cremieuxrecueil·
Think about what it would mean for this study to be true. Your WHOOP or Oura misreporting how well you slept could make the difference between being normal-intelligence or being pretty much intellectually disabled on a given day. We *do not* live in that world.
Crémieux@cremieuxrecueil

This is a garbage study. They did the experiment a first time and the effect was obviously not real: 31.05 IQ points from just telling people a slight lie about how well they slept. In experiment 2, that dropped to 12 points. And then it failed to replicate.

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Dr. Anna MD “In My Opinion”
I entirely disagree with you as do many critical psychiatrists. What is being “treated” under CTO’s for “psychosis”? There are huge pharmacogenetic concerns, dose dependent side effects, lethal drug interactions and potential for dose dumping. BC is an absolute disaster with forced depot neuroleptics injected by unqualified “providers” and the tragedies are front page news as neuroleptics increase drug and alcohol use @Drug_Evidence @BadreNicolas @joannamoncrieff @DrJosefWD @PaulMinotMD @ReadReadj
Dr. Anna MD “In My Opinion” tweet mediaDr. Anna MD “In My Opinion” tweet media
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Chris Aiken, MD
Chris Aiken, MD@chrisaikenmd·
Here's the first trial to test fluoxetine for #depression in children under 6: psych-partners.com/fluoxetine-fir… A positive signal, but agitation is a risk, and a single study doesn't change the fact that Parent-Child Interaction Therapy has the best evidence in this age group.
Chris Aiken, MD tweet media
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
I’m not familiar with that marketing, but certainly more people with psychotic disorders in the US should be offered and treated with long acting injectable antipsychotics than currently are. Too many barriers to that here, unfortunately. They are used much more frequently in Europe, with better outcomes for patients. Sad that they are not offered earlier in people’s care in the US. Most are available as generics without any marketing.
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Brandon del Pozo
Brandon del Pozo@BrandondelPozo·
I studied for the Stuy test without a tutor, by myself, with used test prep booklets another kid discarded. These days, quality prep materials are more available, and often free. Calling a good first gen immigrant family environment a form of "privilege" is a little disingenuous.
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
@drannamedical @chrisaikenmd It's a study from Iran, published in an obscure journal. I know of a few studies from Iran that were likely fabricated. You don't like psychiatry to begin with but jeez, consider the source.
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
@chrisaikenmd Yeah, not for giving antidepressants to children under six. I'm in general a strong advocate for antidepressants even in this environment but this is not supportable.
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
@PSSD_Info It's really important to study and, AI or not, is a reasonable hypothesis to test. The concept of tardive withdrawal also important to study, as hard as that might be to do.
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Natalie
Natalie@PSSD_Info·
@RecoveryDoctor I didn’t proofread the AI well bc the “proteins not lost” part wasn’t consistent with this study ⬇️ Seems harder to reconcile protein changes w/ tardive onsets than a signaling issue but per AI, protein changes could be downstream of signaling issue or exist in subclinical state.
Natalie tweet media
Natalie@PSSD_Info

Adolescent fluoxetine produced lasting ⬇️ ERK-CREB signaling activation in hippocampus & prefrontal cortex, as well as ⬇️ in proBDNF & mature BDNF protein in prefrontal cortex. Total ERK & CREB protein levels were unchanged, indicating ⬇️ signaling, not ⬇️ protein expression. 3/n

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Natalie
Natalie@PSSD_Info·
A hypothesis for SRI "protracted withdrawal" (I've advocated for the term SRI-induced neurological dysfunction #SIND as it can't be understood as a traditional withdrawal syndrome), integrating animal study findings & clinical observations (including the puzzle of tardive onsets)
Natalie tweet media
Natalie@PSSD_Info

Animal studies potentially relevant to serotonin reuptake inhibitor (SRI) "protracted withdrawal." Starting with: juvenile fluoxetine exposure in female mice resulted in a persistent anxiety-like state, reversed by fluoxetine re-exposure in adulthood. 🧵1/ pmc.ncbi.nlm.nih.gov/articles/PMC80…

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