Infection Prevention RN

Hypothesis: a disproportionate number of COVID-aware people are the black sheep of their families.

Last Wednesday at 7:30pm I got Novovax for the first time. I felt fine immediately following. But starting Thursday I had severe headaches and a feeling like I couldn’t think. It’s like dementia. The headaches are gone but now my brain no longer works. How long does this last?

100%. For more context, the way that all infections transmitted through the respiratory route work (including COVID) is that they spend a couple of days replicating in the Upper Respiratory Tract (nose and throat) until there are high enough numbers to overwhelm all of the body’s defenses (including the systemic immunity created by vaccines elsewhere in the body). At that point, it creates a full-blown infection that translocates to the lower respiratory tract, the brain, the various reservoirs around the body that cause long covid persistence, etc. That should be a basic enough concept, but many truly still don’t understand that. And if you do, not trying to be patronizing, but there are an entire group of influencers in the COVID space dedicated to pumping out propaganda that confuses people to the point that they forget these basic principles of biology, or never bother to learn them in the first place. The immune response in those mucosal areas is much more blunted compared with the rest of the body. For example, you don’t have to worry about breathing in a few virions straight into your lungs, Novavax’s protection will pretty much always be durable enough to take care of that. In the upper respiratory tract, Novavax and Matrix-M does represent the best mucosal protection that we’ve ever managed to achieve from a vaccine, but it’s still not enough to fully block all infection, although it often does at lower doses. With that basic understanding, it becomes pretty obvious that nasal sprays can and should be an integral part of any layered defense strategy against COVID. If you inactivate a virus, stop cell binding, and/or stop replication in the URT, you can stop infections from progressing. The mechanism of action is plenty sound. Influencers will often complain about the lack of randomized clinical trials in the space, but if you take more then 2 seconds to think about it, how would those be expected to happen when you can produce most of these nasal sprays for dirt cheap? Where are they going to be getting the funding needed to accomplish those studies? That said, we do still have some. There is real-world evidence in support of 3 sprays in particular: Iota-carrageenan, Nitric oxide, and Azelastine I can get into a lot more specifics about the different ingredients and brands available (or just dig up some of my posts), just let me know if there’s anything you’d like to know in that regard, but that’s the basic premise

Reporter: Why didn't you tell allies about the war before attacking Iran? Trump: We wanted it to be a surprise. Who knows better about surprise than Japan? Why didn't you tell me about Pearl Harbor?