Steve Jacobsen

Our paper is just out nature.com/articles/s4147… from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x.  Looking for postdocs to join the team for the next phase of this work!

Amazing new 📜 from @TrevorWeiss480 and @SJacobsenUCLA showing the creation of transgene-free, genome-edited plants which pass those edits to the next generation using viruses and TnpBs🤯🤯 nature.com/articles/s4147…

Excited to share work from Zhongshou Wu in our lab showing that GDE1 and REM transcription factors help shape DNA methylation patterning. Together with work from Julie Law’s lab also just out, this shows an important way that genetics directs epigenetics. biorxiv.org/content/10.110…

Why is it that gene promoters are so good at avoiding DNA methylation? Work from Ming Wang, Yan He et al., shows that H3K4me3, enriched at promoters, acts as an anti-DNA methylation mark by recruiting DNA demethylase enzymes! Nice work guys! rdcu.be/d9rPo

Excited to share a new paper from the CRISPR team in the Jacobsen, Doudna, and Banfield labs on viral delivery of TnpB and wRNA for transgene free germline editing in plants. biorxiv.org/content/10.110…

The mechanism of MBD6 mediated silencing of genes and transposons. Beautiful story😍 Congratulations @Brandon78447992 , @SJacobsenUCLA and colleagues 🎉🎉🎉

@JasAmerasekera @NSF @scribetx @SJacobsenUCLA Congrats Jasmine!!!

Cool epigenome editing screen from @SJacobsenUCLA. They found the first protein I ever published on: JMJ14 (K4 demethylase). JMJ14 leads to silencing of the target, but no change in DNAme (or K27me3). We saw in the jmj14 mutant there was a DNAme defect 🤔 nature.com/articles/s4147…

@maxvcg Thanks Max! Part two of this story coming out in Nature Comm soon which should fill in some gaps. JMJ14 works at RdDM sites as you showed earlier. But also works in polycomb complexes to silence, along with H3K27me3, in a DNA methylation independent manner.

Congrats to @themicrobeguy @evan_groover @Dylan_Smock @AmyReginaEggers @patrick_pausch @bradyfcress @bstask @dfsavage @SJacobsenUCLA @doudna_lab et al. on their work discovering the diversity of #CRISPR systems in phages! Thanks for using #crispresso2! doi.org/10.1016/j.cell…

Integrative Epigenetics in Plants #CSHAsia Abstract submission deadline is Oct 21. Keynotes by Profs. Steve Jacobsen @SJacobsenUCLA and Tetsuji Kakutani. Come and see amazing speakers at Awaji, Japan in December! Japan resumes VISA-FREE entry for travelers from 68-countries.

Check out the latest efforts led by Zheng Li and @SJacobsenUCLA, on applying CasΦ towards editing plant genomes!

My second paper is available in biorxiv! We discovered that the transcriptional derepression that we observed in mbd5/6 and silenzio mutant plants last year (science.org/doi/10.1126/sc…) was actually happening only in pollen! Why?👇 biorxiv.org/content/10.110… @SJacobsenUCLA

Very excited that our efforts to identify the elusive CMD2 gene for Cassava Mosaic Disease resistance are finally published @NatureComms. Very proud to be part of this project – stuff like this is why I got into plant science! nature.com/articles/s4146…

Very honoured to have been elected an EMBO member - thank you very much to all who supported my election & group members & colleagues who helped me achieve this!

@hendersi Congratulations Ian!

Inari Agriculture has a bunch of open positions in Boston, Ghent and Indiana. inari.com/careers

We are looking for a postdoc to join a team creating CRISPR-based tools for controlling gene expression by targeting different types of DNA methylation related and non DNA methylation related epigenetic modifications.

We broke ground on our SEEDesign greenhouse expansion! Expanding our capacity to develop step-change products with predictive design & multiplex gene editing. Thanks @GovHolcomb, @Indiana_EDC @PurdueAgDean, state/local officials who joined us as we expand our footprint in IN.

So happy to share my first paper, published today in Science! 😊 science.sciencemag.org/content/early/… How does DNA methylation repress genes and transposons? What acts downstream of the methyl-mark? Such a fundamental question. Yet, in plants this was pretty much unknown 👇👇 @SJacobsenUCLA